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Targeted Learning is a subfield of statistics that unifies advances in causal inference, machine learning and statistical theory to help answer scientifically impactful questions with statistical confidence. Targeted Learning is driven by…

Network meta-analysis (NMA) is a technique used in medical statistics to combine evidence from multiple medical trials. NMA defines an inference and information processing problem on a network of treatment options and trials connecting the…

Statistical Mechanics · Physics 2022-11-30 Annabel L. Davies , Tobias Galla

Machine learning, and in particular neural network models, have revolutionized fields such as image, text, and speech recognition. Today, many important real-world applications in these areas are driven by neural networks. There are also…

Probability · Mathematics 2019-11-12 Justin Sirignano , Konstantinos Spiliopoulos

This paper describes a new approach on optimization of constraint satisfaction problems (CSPs) by means of substituting sub-CSPs with locally consistent regular membership constraints. The purpose of this approach is to reduce the number of…

Artificial Intelligence · Computer Science 2019-08-19 Sven Löffler , Ke Liu , Petra Hofstedt

We study the phase diagram and the algorithmic hardness of the random `locked' constraint satisfaction problems, and compare them to the commonly studied 'non-locked' problems like satisfiability of boolean formulas or graph coloring. The…

Disordered Systems and Neural Networks · Physics 2008-12-09 Lenka Zdeborová , Marc Mézard

In this work we explore encoding strategies learned by statistical models of sensory coding in noisy spiking networks. Early stages of sensory communication in neural systems can be viewed as encoding channels in the information-theoretic…

Neurons and Cognition · Quantitative Biology 2020-06-30 M. E. Rule , M. Sorbaro , M. H. Hennig

The application of machine learning to physics problems is widely found in the scientific literature. Both regression and classification problems are addressed by a large array of techniques that involve learning algorithms. Unfortunately,…

Machine Learning · Computer Science 2022-10-03 Umberto Michelucci , Francesca Venturini

Many real world problems naturally appear as constraints satisfaction problems (CSP), for which very efficient algorithms are known. Most of these involve the combination of two techniques: some direct propagation of constraints between…

Artificial Intelligence · Computer Science 2013-04-12 Denis Berthier

We develop a general framework for estimating function-valued parameters under equality or inequality constraints in infinite-dimensional statistical models. Such constrained learning problems are common across many areas of statistics and…

Machine Learning · Statistics 2025-07-22 Razieh Nabi , Nima S. Hejazi , Mark J. van der Laan , David Benkeser

We investigate the problem of learning the structure of a Markov network from data. It is shown that the structure of such networks can be described in terms of constraints which enables the use of existing solver technology with…

Artificial Intelligence · Computer Science 2013-10-04 Jukka Corander , Tomi Janhunen , Jussi Rintanen , Henrik Nyman , Johan Pensar

Statistical inference problems arising within signal processing, data mining, and machine learning naturally give rise to hard combinatorial optimization problems. These problems become intractable when the dimensionality of the data is…

Statistical Mechanics · Physics 2017-04-27 Adel Javanmard , Andrea Montanari , Federico Ricci-Tersenghi

Emerging applications of machine learning in numerous areas involve continuous gathering of and learning from streams of data. Real-time incorporation of streaming data into the learned models is essential for improved inference in these…

Machine Learning · Computer Science 2020-12-01 Matthew Nokleby , Haroon Raja , Waheed U. Bajwa

Many machine learning approaches are characterized by information constraints on how they interact with the training data. These include memory and sequential access constraints (e.g. fast first-order methods to solve stochastic…

Machine Learning · Computer Science 2014-10-29 Ohad Shamir

In physics we often use very simple models to describe systems with many degrees of freedom, but it is not clear why or how this success can be transferred to the more complex biological context. We consider models for the joint…

Neurons and Cognition · Quantitative Biology 2024-12-06 Luisa Ramirez , William Bialek , Stephanie E. Palmer , David J. Schwab

Neural networks are often regarded as "black boxes" due to their complex functions and numerous parameters, which poses significant challenges for interpretability. This study addresses these challenges by introducing methods to enhance the…

Machine Learning · Statistics 2024-09-26 Mohamad Yamen AL Mohamad , Hossein Bevrani , Ali Akbar Haydari

To model combinatorial decision problems involving uncertainty and probability, we introduce stochastic constraint programming. Stochastic constraint programs contain both decision variables (which we can set) and stochastic variables…

Artificial Intelligence · Computer Science 2009-03-09 Toby Walsh

In the area of physical simulations, nearly all neural-network-based methods directly predict future states from the input states. However, many traditional simulation engines instead model the constraints of the system and select the state…

Machine Learning · Computer Science 2022-01-31 Yulia Rubanova , Alvaro Sanchez-Gonzalez , Tobias Pfaff , Peter Battaglia

Complex functional brain network analyses have exploded over the last eight years, gaining traction due to their profound clinical implications. The application of network science (an interdisciplinary offshoot of graph theory) has…

Methodology · Statistics 2013-10-28 Sean L. Simpson , F. DuBois Bowman , Paul J. Laurienti

Despite the striking successes of deep neural networks trained with gradient-based optimization, these methods differ fundamentally from their biological counterparts. This gap raises key questions about how nature achieves robust,…

Machine Learning · Computer Science 2025-10-15 Mattia Scardecchia

Neural networks (NN) perform well in diverse tasks, but sometimes produce nonsensical results to humans. Most NN models "solely" learn from (input, output) pairs, occasionally conflicting with human knowledge. Many studies indicate…

Machine Learning · Computer Science 2024-08-22 Mooho Song , Jay-Yoon Lee