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Molecular phylogenetic techniques do not generally account for such common evolutionary events as site insertions and deletions (known as indels). Instead tree building algorithms and ancestral state inference procedures typically rely on…

Probability · Mathematics 2011-09-07 Alexandr Andoni , Constantinos Daskalakis , Avinatan Hassidim , Sebastien Roch

Advances in bio-technology have made available massive amounts of functional, structural and genomic data for many biological sequences. This increased availability of heterogeneous biological data has resulted in biological applications…

Computational Engineering, Finance, and Science · Computer Science 2013-02-26 Srikrishnan Divakaran , Arpit Mithal , Namit Jain

Affordable, high-quality whole-genome assemblies have made it possible to construct rich pangenomes that capture haplotype diversity across many species. As these datasets grow, they motivate the development of specialized techniques…

Genomics · Quantitative Biology 2025-12-19 Gorkem Kadir Solun , Ugur Dogrusoz

The present article is the first of a series whose goal is to define a logical formalism in which it is possible to reason about genetics. In this paper, we introduce the main concepts of our language whose domain of discourse consists of a…

Category Theory · Mathematics 2020-04-07 Rémy Tuyéras

We present an efficient phylogenetic reconstruction algorithm allowing insertions and deletions which provably achieves a sequence-length requirement (or sample complexity) growing polynomially in the number of taxa. Our algorithm is…

Probability · Mathematics 2013-02-25 Constantinos Daskalakis , Sebastien Roch

We tackle the problem of multi-class relational sequence learning using relevant patterns discovered from a set of labelled sequences. To deal with this problem, firstly each relational sequence is mapped into a feature vector using the…

Artificial Intelligence · Computer Science 2010-06-29 Nicola Di Mauro , Teresa M. A. Basile , Stefano Ferilli , Floriana Esposito

Factor analysis provides linear factors that describe relationships between individual variables of a data set. We extend this classical formulation into linear factors that describe relationships between groups of variables, where each…

Machine Learning · Statistics 2014-12-03 Arto Klami , Seppo Virtanen , Eemeli Leppäaho , Samuel Kaski

In this paper we address the problem of modeling relational data, which appear in many applications such as social network analysis, recommender systems and bioinformatics. Previous studies either consider latent feature based models but…

Data Structures and Algorithms · Computer Science 2012-04-13 Sheng Gao , Ludovic Denoyer , Patrick Gallinari

Entity alignment is to find identical entities in different knowledge graphs. Although embedding-based entity alignment has recently achieved remarkable progress, training data insufficiency remains a critical challenge. Conventional…

Artificial Intelligence · Computer Science 2022-03-15 Kexuan Xin , Zequn Sun , Wen Hua , Bing Liu , Wei Hu , Jianfeng Qu , Xiaofang Zhou

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

Molecular Networks · Quantitative Biology 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

It is well-known in biology that ants are able to find shortest paths between their nest and the food by successive random explorations, without any mean of communication other than the pheromones they leave behind them. This striking…

Probability · Mathematics 2020-10-13 Daniel Kious , Cécile Mailler , Bruno Schapira

Deep generative models for graphs have exhibited promising performance in ever-increasing domains such as design of molecules (i.e, graph of atoms) and structure prediction of proteins (i.e., graph of amino acids). Existing work typically…

Machine Learning · Computer Science 2021-01-21 Wenbin Zhang , Liming Zhang , Dieter Pfoser , Liang Zhao

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

For graph classification tasks, many traditional kernel methods focus on measuring the similarity between graphs. These methods have achieved great success on resolving graph isomorphism problems. However, in some classification problems,…

Machine Learning · Computer Science 2021-02-18 Jianming Huang , Hiroyuki Kasai

Formal modelling of Multi-Agent Systems (MAS) is a challenging task due to high complexity, interaction, parallelism and continuous change of roles and organisation between agents. In this paper we record our research experience on formal…

Multiagent Systems · Computer Science 2010-08-20 Petros Kefalas , Ioanna Stamatopoulou

Mapping between sequence and structure is currently an open problem in structural biology. Despite many experimental and computational efforts it is not clear yet how the structure is encoded in the sequence. Answering this question may…

Biomolecules · Quantitative Biology 2013-10-08 Iddo Friedberg

Most of the grand challenges of humanity today involve complex agent-based systems, such as epidemiology, economics or ecology. However, remains as a pending task the challenge of identifying the general principles underlying their…

General Finance · Quantitative Finance 2020-10-19 Martin Jaraiz

Using a simple model for the trail formation of ants, the relation between i)the schedule of feeding which represents the unsteady natural environment, ii)emerging patterns of trails connecting a nest with food resources, and iii)the…

Populations and Evolution · Quantitative Biology 2009-11-10 Tomomi Tao , Hiroyuki Nakagawa , Masato Yamasaki , Hiraku Nishimori

Multi-label classification is an important yet challenging task in natural language processing. It is more complex than single-label classification in that the labels tend to be correlated. Existing methods tend to ignore the correlations…

Computation and Language · Computer Science 2018-06-18 Pengcheng Yang , Xu Sun , Wei Li , Shuming Ma , Wei Wu , Houfeng Wang

Evolutionary modeling applications are the best way to provide full information to support in-depth understanding of evaluation of organisms. These applications mainly depend on identifying the evolutionary history of existing organisms and…

Computational Engineering, Finance, and Science · Computer Science 2018-06-01 Sara Shehab , Sameh Abdulah , Arabi E. Keshk