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Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation onto architectures familiar to computer science remains an…

Biological Physics · Physics 2026-03-31 Jan Kocka , Kabir Husain , Jaime Agudo-Canalejo

The human brain represents the only known example of general intelligence that naturally aligns with human values. On a mere 20-watt power budget, the brain achieves robust learning and adaptive decision-making in ways that continue to…

Neurons and Cognition · Quantitative Biology 2025-08-12 PK Douglas

Neuromorphic computing applies insights from neuroscience to uncover innovations in computing technology. In the brain, billions of interconnected neurons perform rapid computations at extremely low energy levels by leveraging properties…

Neural and Evolutionary Computing · Computer Science 2020-04-28 E. Paxon Frady , Garrick Orchard , David Florey , Nabil Imam , Ruokun Liu , Joyesh Mishra , Jonathan Tse , Andreas Wild , Friedrich T. Sommer , Mike Davies

A neuron transforms its input into output spikes, and this transformation is the basic unit of computation in the nervous system. The spiking response of the neuron to a complex, time-varying input can be predicted from the detailed…

Neurons and Cognition · Quantitative Biology 2011-12-19 Michael Famulare , Adrienne Fairhall

Allosteric regulation in proteins is often accompanied by conformational changes that facilitate transmission of mechanical signals between distant ligand binding sites. Typically, these deformations are classified in terms of specific…

Soft Condensed Matter · Physics 2024-01-26 Jason W. Rocks , Eleni Katifori , Andrea J. Liu

The overdamped Brownian dynamics of a harmonic oscillator is a paradigmatic system in non-equilibrium statistical mechanics, which reliably models relevant stochastic systems such as colloidal particles submitted to optical confinement. In…

Statistical Mechanics · Physics 2022-09-08 Antonio Patrón , Antonio Prados , Carlos A. Plata

We consider a standard distributed optimisation setting where $N$ machines, each holding a $d$-dimensional function $f_i$, aim to jointly minimise the sum of the functions $\sum_{i = 1}^N f_i (x)$. This problem arises naturally in…

Machine Learning · Computer Science 2021-12-08 Dan Alistarh , Janne H. Korhonen

We have calculated the key characteristics of associative (content-addressable) spatial-temporal memories based on neuromorphic networks with restricted connectivity - "CrossNets". Such networks may be naturally implemented in…

Neural and Evolutionary Computing · Computer Science 2017-07-14 Dmitri Gavrilov , Dmitri Strukov , Konstantin K. Likharev

The $\textit{von Neumann Computer Architecture}$ has a distinction between computation and memory. In contrast, the brain has an integrated architecture where computation and memory are indistinguishable. Motivated by the architecture of…

Computational Complexity · Computer Science 2023-05-11 Kordag Mehmet Kilic , Jin Sima , Jehoshua Bruck

Adaptive physical and biological systems continually process fluctuating information from their environments. When the environment is nonstationary, inference itself becomes a nonequilibrium process with thermodynamic cost. We analyse a…

Statistical Mechanics · Physics 2026-03-23 Aditya Gupta

We study systems of Brownian particles on the real line, which interact by splitting the local times of collisions among themselves in an asymmetric manner. We prove the strong existence and uniqueness of such processes and identify them…

Probability · Mathematics 2012-10-02 Ioannis Karatzas , Soumik Pal , Mykhaylo Shkolnikov

This paper presents the Task-Parameter Nexus (TPN), a learning-based approach for online determination of the (near-)optimal control parameters of model-based controllers (MBCs) for tracking tasks. In TPN, a deep neural network is…

Robotics · Computer Science 2025-04-10 Sheng Cheng , Ran Tao , Yuliang Gu , Shenlong Wang , Xiaofeng Wang , Naira Hovakimyan

When monitoring the dynamics of stochastic systems, such as interacting particles agitated by thermal noise, disentangling deterministic forces from Brownian motion is challenging. Indeed, we show that there is an information-theoretic…

Soft Condensed Matter · Physics 2020-04-16 Anna Frishman , Pierre Ronceray

Topological quantum computation has recently emerged as one of the most exciting approaches to constructing a fault-tolerant quantum computer. The proposal relies on the existence of topological states of matter whose quasiparticle…

Strongly Correlated Electrons · Physics 2009-11-13 Chetan Nayak , Steven H. Simon , Ady Stern , Michael Freedman , Sankar Das Sarma

We analyze the thermodynamic cost of a logically reversible Brownian Turing machine operating in the first-passage time protocol based on the stochastic thermodynamics of resetting. In this framework, the thermodynamic cost of computation…

Statistical Mechanics · Physics 2023-12-01 Yasuhiro Utsumi , Dimitry Golubev , Ferdinand Peper

Recently, the demand of low-power deep-learning hardware for industrial applications has been increasing. Most existing artificial intelligence (AI) chips have evolved to rely on new chip technologies rather than on radically new hardware…

Machine Learning · Computer Science 2020-02-14 Byungik Ahn

The quantum statistics mechanism is very powerful for investigating the equilibrium states and the phase transitions in complex spin disorder systems. The spin disorder systems act as an interdisciplinary platform for solving the optimum…

General Physics · Physics 2025-06-17 Zhidong Zhang

The rapid proliferation of Deep Learning is increasingly constrained by its heavy reliance on high-performance hardware, particularly Graphics Processing Units (GPUs). These specialized accelerators are not only prohibitively expensive and…

Machine Learning · Computer Science 2026-01-06 Emrah Mete , Emin Erkan Korkmaz

Tensor networks (TNs) are a central computational tool in quantum science and artificial intelligence. However, the lack of unified software interface across tensor-computing frameworks severely limits the portability of TN applications,…

Quantum Physics · Physics 2026-01-01 Rong-Yang Sun , Tomonori Shirakawa , Hidehiko Kohshiro , D. N. Sheng , Seiji Yunoki

We present a method to design driving protocols that achieve fast thermal equilibration of a system of interest using techniques inspired by machine learning training algorithms. For example, consider a Brownian particle manipulated by…

Statistical Mechanics · Physics 2025-06-25 Diego Rengifo , Gabriel Téllez