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Continuum mathematical models for collective cell motion normally involve reaction-diffusion equations, such as the Fisher-KPP equation, with a linear diffusion term to describe cell motility and a logistic term to describe cell…

Biological Physics · Physics 2019-07-24 Scott W McCue , Wang Jin , Timothy J Moroney , Kai-Yin Lo , Shih-En Chou , Matthew J Simpson

The degenerate Cahn-Hilliard equation is a standard model to describe living tissues. It takes into account cell populations undergoing short-range attraction and long-range repulsion effects. In this framework, we consider the usual…

Analysis of PDEs · Mathematics 2022-04-28 Benoît Perthame , Alexandre Poulain

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We present a stochastic model which describes fronts of cells invading a wound. In the model cells can move, proliferate, and experience cell-cell adhesion. We find several qualitatively different regimes of front motion and analyze the…

Cell Behavior · Quantitative Biology 2009-11-13 Evgeniy Khain , Leonard M. Sander , Casey M. Schneider-Mizell

We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

Analysis of PDEs · Mathematics 2016-05-26 Harald Garcke , Kei Fong Lam

An asymptotic analysis for a system with equation and dynamic boundary condition of Cahn-Hilliard type is carried out as the coefficient of the surface diffusion acting on the phase variable tends to 0, thus obtaining a forward-backward…

Analysis of PDEs · Mathematics 2021-06-03 Pierluigi Colli , Takeshi Fukao , Luca Scarpa

We present a discrete stochastic model which represents many of the salient features of the biological process of wound healing. The model describes fronts of cells invading a wound. We have numerical results in one and two dimensions. In…

Cell Behavior · Quantitative Biology 2009-11-11 Thomas Callaghan , Evgeniy Khain , Leonard M. Sander , Robert M. Ziff

We consider a mathematical model coupling the Cahn-Hilliard system for phase separation with an additional equation describing the diffusion process of a chemical quantity whose concentration influences the physical process. The main…

Analysis of PDEs · Mathematics 2025-11-17 Giulio Schimperna , Antonio Segatti

We consider an evolutionary PDE system coupling the Cahn-Hilliard equation with singular potential, mass source and transport effects, to a Brinkman-type relation for the macroscopic velocity field and to a further equation describing the…

Analysis of PDEs · Mathematics 2024-11-20 Giulio Schimperna

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

Analysis of PDEs · Mathematics 2017-05-04 Harald Garcke , Kei Fong Lam

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…

Analysis of PDEs · Mathematics 2019-06-27 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We propose and investigate a model for lipid raft formation and dynamics in biological membranes. The model describes the lipid composition of the membrane and an interaction with cholesterol. To account for cholesterol exchange between…

Analysis of PDEs · Mathematics 2016-03-15 Harald Garcke , Johannes Kampmann , Andreas Rätz , Matthias Röger

We study the Cahn-Hilliard-Biot model with respect to its mathematical well-posedness. The system models flow through deformable porous media in which the solid material has two phases with distinct material properties. The two phases of…

Analysis of PDEs · Mathematics 2024-10-04 Marvin Fritz

The Cahn-Hilliard equation is one of the most common models to describe phase separation processes in mixtures of two materials. For a better description of short-range interactions between the material and the boundary, various dynamic…

Numerical Analysis · Mathematics 2023-01-23 Stefan Metzger

The Cahn-Hilliard model with reaction terms can lead to situations in which no coarsening is taking place and, in contrast, growth and division of droplets occur which all do not grow larger than a certain size. This phenomenon has been…

Analysis of PDEs · Mathematics 2025-11-07 Harald Garcke , Kei Fong Lam , Robert Nürnberg , Andrea Signori

In this paper, we study a generalized Camassa-Holm (gCH) model with both dissipation and dispersion, which has (N + 1)-order nonlinearities and includes the following three integrable equations: the Camassa-Holm, the Degasperis-Procesi, and…

Mathematical Physics · Physics 2015-11-12 Qiaoyi Hu , Zhijun Qiao

Mathematical models describing the spatial spreading and invasion of populations of biological cells are often developed in a continuum modelling framework using reaction-diffusion equations. While continuum models based on linear diffusion…

Cellular Automata and Lattice Gases · Physics 2024-01-23 Matthew J Simpson , Keeley M Murphy , Scott W McCue , Pascal R Buenzli

Mechanical effects have mostly been neglected so far in phase field tumour models that are based on a Cahn-Hilliard approach. In this paper we study a macroscopic mechanical model for tumour growth in which cell-cell adhesion effects are…

Analysis of PDEs · Mathematics 2021-01-20 Harald Garcke , Kei Fong Lam , Andrea Signori

We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…

Analysis of PDEs · Mathematics 2014-01-14 Benoît Perthame , Fernando Quirós , Min Tang , Nicolas Vauchelet

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

Analysis of PDEs · Mathematics 2022-06-22 Patrik Knopf , Andrea Signori
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