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Rare event simulation and estimation for systems in equilibrium are among the most challenging topics in molecular dynamics. As was shown by Jarzynski and others, nonequilibrium forcing can theoretically be used to obtain equilibrium rare…

Optimization and Control · Mathematics 2015-06-11 Carsten Hartmann , Christof Schütte

We propose and analyze a process that extracts useful work from a single active particle maintained at constant temperature in a harmonic potential by measuring the relative sign of the self-propulsion and the confining force and then…

Statistical Mechanics · Physics 2026-03-09 Grzegorz Szamel

Two identities in statistical mechanics involving entropy differences (or ratios of density of states) at constant energy are derived. The first provides a nontrivial extension of the Jarzynski equality to the microcanonical ensemble [C.…

Statistical Mechanics · Physics 2009-11-10 Artur B. Adib

Most natural and engineered processes, such as biomolecular reactions, protein folding, and population dynamics, occur far from equilibrium and, therefore, cannot be treated within the framework of classical equilibrium thermodynamics. The…

Soft Condensed Matter · Physics 2016-01-07 Aykut Argun , Ali-Reza Moradi , Erçağ Pince , Gokhan Baris Bagci , Giovanni Volpe

Estimating free energy differences, an important problem in computational drug discovery and in a wide range of other application areas, commonly involves a computationally intensive process of sampling a family of high-dimensional…

The optimal protocols for the irreversible work achieve their maximum usefulness if their work fluctuations are the smallest ones. In this work, for classical and isothermal processes subjected to finite-time and weak drivings, I show that…

Statistical Mechanics · Physics 2023-11-14 Pierre Nazé

Work in the paradigm of the quantum fluctuation theorems of Crooks and Jarzynski is determined by projective measurements of energy at the beginning and end of the force protocol. In analogy to classical systems, we consider an alternative…

Statistical Mechanics · Physics 2015-08-04 B. Prasanna Venkatesh , Gentaro Watanabe , Peter Talkner

Returning a system to a desired state under a force field involves a thermodynamic cost, i.e., {\it work}. This cost fluctuates for a small-scale system from one experimental realization to another. We introduce a general framework to…

Statistical Mechanics · Physics 2022-12-07 Deepak Gupta , Carlos A. Plata

Accurate free-energy calculations are essential for predicting thermodynamic properties and phase stability, but existing methods are limited: phonon-based approaches neglect anharmonicity and liquids, while molecular dynamics (MD) is…

Materials Science · Physics 2025-11-19 Ekaterina Spirande , Timofei Miryashkin , Andrei Kolmakov , Alexander Shapeev

Recently, Jarzynski suggested a striking thermodynamic equation that relates free energy change of a system and work done on the system during arbitrary nonequilibrium processes, which has been believed to hold irrespective of detailed…

Statistical Mechanics · Physics 2016-08-31 Jaeyoung Sung

We perform an analytic study on the stochastic thermodynamics of a small classical particle trapped in a time dependent single-well potential in the highly underdamped limit. It is shown that the nonequilibrium probability density function…

Statistical Mechanics · Physics 2019-06-26 Domingos S. P. Salazar , Sérgio A. Lira

Inexpensive machine learning potentials are increasingly being used to speed up structural optimization and molecular dynamics simulations of materials by iteratively predicting and applying interatomic forces. In these settings, it is…

Chemical Physics · Physics 2023-09-12 Jonas Busk , Mikkel N. Schmidt , Ole Winther , Tejs Vegge , Peter Bjørn Jørgensen

Recent experiments have implemented resetting by means of an external trap, whereby a system relaxes to the minimum of the trap and is reset in a finite time. In this work, we set up and analyse the thermodynamics of such a protocol. We…

Statistical Mechanics · Physics 2024-10-01 Kristian Stølevik Olsen , Deepak Gupta , Francesco Mori , Supriya Krishnamurthy

Stochastic dynamics in the energy representation is employed as a method to study non-equilibrium Brownian-like systems. It is shown that the equation of motion for the energy of such systems can be taken in the form of the Langevin…

Statistical Mechanics · Physics 2015-05-18 Bohdan I. Lev , Alexei D. Kiselev

We combine the formalisms of diagonal entropy and Jarzynski Equality to study the thermodynamic properties of closed quantum systems. Applying this approach to a quantum harmonic oscillator, the diagonal entropy offers a notion of…

Quantum Physics · Physics 2013-07-09 Van A. Ngo , Stephan Haas

This report presents the application of polynomial regression for estimating free energy differences using thermodynamic integration. We employ linear regression to construct a polynomial that optimally fits the thermodynamic integration…

Computational Physics · Physics 2008-10-02 Conrad Shyu , F. Marty Ytreberg

We project the Wilson/Polchinski renormalization group equation onto its uniform external field dependent effective free energy and connected Green's functions. The result is a hierarchy of equations which admits a choice of "natural"…

High Energy Physics - Theory · Physics 2007-05-23 Geoffrey R. Golner

We solve the random energy model when the energies of the configurations take only integer values. In the thermodynamic limit, the average overlaps remain size dependent and oscillate as the system size increases. While the extensive part…

Disordered Systems and Neural Networks · Physics 2022-06-22 Bernard Derrida , Peter Mottishaw

A method for calculating the short-range order part of the free energy of order-disorder systems is proposed. The method is based on the apllication of the cumulant expansion to the exact configurational entropy. Second-order correlation…

Statistical Mechanics · Physics 2009-10-31 Igor Tsatskis

How much free energy is irreversibly lost during a thermodynamic process? For deterministic protocols, lower bounds on energy dissipation arise from the thermodynamic friction associated with pushing a system out of equilibrium in finite…

Statistical Mechanics · Physics 2021-03-26 Samuel J. Bryant , Benjamin B. Machta