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The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

Quantitative Methods · Quantitative Biology 2021-05-06 Spencer Farrell , Garrett Stubbings , Kenneth Rockwood , Arnold Mitnitski , Andrew Rutenberg

Microbial ecosystems exhibit a surprising amount of functionally relevant diversity at all levels of taxonomic resolution, presenting a significant challenge for most modeling frameworks. A long-standing hope of theoretical ecology is that…

Populations and Evolution · Quantitative Biology 2025-10-09 Jacob Moran , Lucas C. Graham , Mikhail Tikhonov

Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional methods frequently struggle with the inherent complexity,…

Machine Learning · Computer Science 2025-03-06 Runlong Yu , Shengyu Chen , Yiqun Xie , Xiaowei Jia

Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, due to the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object…

Populations and Evolution · Quantitative Biology 2009-11-10 David J. Earl , Michael W. Deem

The mutual influence of dynamics and structure is a central issue in complex systems. In this paper we study by simulation slow evolution of network under the feedback of a local-majority-rule opinion process. If performance-enhancing local…

Physics and Society · Physics 2009-11-13 Zhen Shao , Haijun Zhou

The far-reaching consequences of ecological interactions in the dynamics of biological communities remain an intriguing subject. For decades, competition has been a cornerstone in ecological processes, but mounting evidence shows that…

Populations and Evolution · Quantitative Biology 2021-07-19 F. Meloni , G. Nakamura , B. Grammaticos , A. S. Martinez , M. Badoual

This chapter introduces evolutionary antifragility as the time-scale interaction characteristics of a natural dynamic system. It describes the benefit derived from input distribution unevenness, based on the emergent system dynamics and its…

Populations and Evolution · Quantitative Biology 2025-04-25 Cristian Axenie , Roman Bauer , Oliver Lopez Corona , Elvia Ramirez-Carrillo , Ari Barnett , Jeffrey West

Our planet is roughly closed to matter, but open to energy input from the sun. However, to harness this energy, organisms must transform matter from one chemical (redox) state to another. For example, photosynthetic organisms can capture…

Populations and Evolution · Quantitative Biology 2024-03-04 Akshit Goyal , Avi I. Flamholz , Alexander P. Petroff , Arvind Murugan

Empirical evidence suggesting that living systems might operate in the vicinity of critical points, at the borderline between order and disorder, has proliferated in recent years, with examples ranging from spontaneous brain activity to…

Statistical Mechanics · Physics 2014-07-25 Jorge Hidalgo , Jacopo Grilli , Samir Suweis , Miguel A. Munoz , Jayanth R. Banavar , Amos Maritan

It is becoming widely accepted that very early in the origin of life, even before the emergence of genetic encoding, reaction networks of diverse small chemicals might have manifested key properties of life, namely self-propagation and…

Populations and Evolution · Quantitative Biology 2023-01-05 Zhen Peng , Alex Plum , Praful Gagrani , David A. Baum

Future communication networks are expected to achieve deep integration of communication, sensing, and computation, forming a tightly coupled and autonomously operating infrastructure system. However, current reliance on centralized control,…

Networking and Internet Architecture · Computer Science 2025-08-22 Gaosheng Zhao , Dong In Kim

Biological organisms are composed of numerous interconnected biochemical processes. Diseases occur when normal functionality of these processes is disrupted. Thus, understanding these biochemical processes and their interrelationships is a…

Artificial Intelligence · Computer Science 2014-03-04 Saadat Anwar

Software ecosystems are collections of projects that are developed and evolve together in the same environment. Existing literature investigates software ecosystems as isolated entities whose boundaries do not overlap and assumes they are…

Software Engineering · Computer Science 2018-12-14 Eleni Constantinou , Alexandre Decan , Tom Mens

Analogous to living ecosystems in nature, web services form an artificial ecosystem consisting of many tags and their associated media, such as photographs, movies, and web pages created by human users. Concerning biological ecosystems, we…

Social and Information Networks · Computer Science 2019-04-01 Takashi Ikegami , Yasuhiro Hashimoto , Mizuki Oka

Mathematical modelling of the evolution of the size-spectrum dynamics in aquatic ecosystems was discovered to be a powerful tool to have a deeper insight into impacts of human- and environmental driven changes on the marine ecosystem. In…

Analysis of PDEs · Mathematics 2024-01-02 Laura Kanzler , Benoit Perthame , Benoit Sarels

Ecology studies biodiversity in its variety and complexity. It describes how species distribute and perform in response to environmental changes. Ecological processes and structures are highly complex and adaptive. In order to quantify…

Populations and Evolution · Quantitative Biology 2013-10-09 Cang Hui

Dispersal is a well recognized driver of ecological and evolutionary dynamics, and simultaneously an evolving trait. Dispersal evolution has traditionally been studied in single-species metapopulations so that it remains unclear how…

We introduce the Webworld model, which links together the ecological modelling of food web structure with the evolutionary modelling of speciation and extinction events. The model describes dynamics of ecological communities on an…

adap-org · Physics 2007-05-23 Guido Caldarelli , Paul G. Higgs , Alan J. McKane

Nature has engineered complex designs to achieve advanced properties and functionalities through evolution, over millions of years. Many organisms have adapted to their living environment producing extremely efficient materials and…

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui