Related papers: MAPK Cascades as Feedback Amplifiers
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic…
In recent years it is increasingly being recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier. Moreover, it is now well established that…
We present a stochastic framework to study signal transmission in a generic two-step cascade $\text{S} \rightarrow \text{X} \rightarrow \text{Y}$. Starting from a set of Langevin equations obeying Gaussian noise processes we calculate the…
Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and cytoplasmic processes to control cell responses. Genetic mutations in signaling network components are frequently…
We have studied a one-dimensional channel with a wider, straight region irradiated by an external electromagnetic field. In this system the interplay between interference effects and resonance phenomena manifests itself and provides a new…
Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They connect cells throughout the body, including heart myocytes, neurons, and astrocytes. Propagation mediated by gap junctions can be passive or…
Multi-antenna precoding effectively mitigates the interference in wireless networks. However, the resultant performance gains can be significantly compromised in practice if the precoder design fails to account for the inaccuracy in the…
In the context of epidemic spreading, many intricate dynamical patterns can emerge due to the cooperation of different types of pathogens or the interaction between the disease spread and other failure propagation mechanism. To unravel such…
Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate protein function. However, the physical mechanisms…
The macroscopic behaviour of active matter arises from nonequilibrium microscopic processes. In soft materials, active stresses typically drive macroscopic shape changes, which in turn alter the geometry constraining the microscopic…
Acoustic matching layers are widely employed in high-frequency transducers which are excited by different signal types depending on applications. In this study, a theoretical method has been proposed to investigate the dependence of…
One of the pivotal questions in the dynamics of the oceans is related to the cascade of mechanical energy in the abyss and its contribution to mixing. Here, we propose internal wave attractors in the large amplitude regime as a unique…
We present a design framework to induce stable oscillations through mixed feedback control. We provide conditions on the feedback gain and on the balance between positive and negative feedback contributions to guarantee robust oscillations.…
Adenosine 5'-triphosphate (ATP) is the nearly ubiquitous "energy currency" of living organisms, and thus is a crucial participant in the majority of enzymatic reactions. The standard models in enzyme kinetics generally ignore the temporal…
The ability to pick up on language signals in an ongoing interaction is crucial for future machine learning models to collaborate and interact with humans naturally. In this paper, we present an initial study that evaluates intra-episodic…
We consider many-body quantum systems dissipatively coupled by a cascade network, i.e. a setup in which interactions are mediated by unidirectional environmental modes propagating through a linear optical interferometer. In particular we…
Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical…
Autoencoders are composed of coding and decoding units, hence they hold the inherent potential of high-performance data compression and signal compressed sensing. The main disadvantages of current autoencoders comprise the following several…
Cells sense environmental signals and transmit information intracellularly through changes in the abundance of molecular components. Such molecular abundances can be measured in single cells and exhibit significant heterogeneity in clonal…
In this paper, the multiple access channel (MAC) with channel state is analyzed in a scenario where a) the channel state is known non-causally to the transmitters and b) there is perfect causal feedback from the receiver to the…