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Solid-state nanopore and nanopipette sensors are powerful devices for the detection, quantification and structural analysis of biopolymers such as DNA and proteins, especially in carrier-enhanced resistive-pulse sensing. However, hundreds…

Mesoscale and Nanoscale Physics · Physics 2025-10-14 Cengiz J. Khan , Oliver J. Irving , Rand A. Al-Waqfi , Giorgio Ferrari , Tim Albrecht

Chiroptical enantioselective sensing is gaining traction across various applications. However, intrinsic molecular chiroptical responses are weak, and existing amplification approaches add synthesis, manufacturing, or operational complexity…

Optical biosensors are often used to measure kinetic rate constants associated with chemical reactions. Such instruments operate in the \textit{surface-volume} configuration, in which ligand molecules are convected through a fluid-filled…

Molecular Networks · Quantitative Biology 2017-10-13 Ryan M. Evans , David A. Edwards

Nanomechanical oscillators have been employed as transducers to measure force, mass and charge with high sensitivity. They are also used in opto- or electromechanical experiments with the goal of quantum control and phenomena of mechanical…

Optics · Physics 2015-06-03 Emanuel Gavartin , Pierre Verlot , Tobias J. Kippenberg

The development of next generation medicines demand more sensitive and reliable label free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of…

Applied Physics · Physics 2019-05-22 Serena Rollo , Dipti Rani , Renaud Leturcq , Wouter Olthuis , César Pascual García

Magnetoelastic sensors for the detection of low-frequency and low-amplitude magnetic fields are in the focus of research since more than 30 years. In order to minimize the limit of detection (LOD) of such sensor systems, it is of high…

Wireless all-analog biosensor design for concurrent microfluidic and physiological signal monitoring is presented in this work. The key component is an all-analog circuit capable of compressing two analog sources into one analog signal by…

Signal Processing · Electrical Eng. & Systems 2019-07-02 Xueyuan Zhao , Vidyasagar Sadhu , Tuan Le , Dario Pompili , Mehdi Javanmard

This paper introduces a perspective approach for simulating a memristive sensor tailored for low power biological analyte detection. The necessity for such innovation stems from the increasing demand for efficient biosensing technologies…

Applied Physics · Physics 2024-08-13 Manel Bouzouita , Fakhreddine Zayer , Hamdi Belgacem

High-frequency atomic force microscopy has enabled extraordinary new science through large bandwidth, high speed measurements of atomic and molecular structures. However, traditional optical detection schemes restrict the dimensions, and…

Mesoscale and Nanoscale Physics · Physics 2014-03-11 C. Doolin , P. H. Kim , B. D. Hauer , A. J. R MacDonald , J. P Davis

Quantum biosensors offer a promising route to overcome the sensitivity and specificity limitations of conventional biosensing technologies. Their ability to detect biochemical signals at extremely low concentrations makes them strong…

Optics · Physics 2025-08-05 Yasaman Torabi , Shahram Shirani , James P. Reilly

Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…

Applied Physics · Physics 2020-01-08 Yeseul Kim , Hansuek Lee

Heller et. Al. (Science 311, 508 (2006)) demonstrated the first DNA-CN optical sensor by wrapping a piece of double-stranded DNA around the surface of single-walled carbon nanotubes (CN). This new type of optical device can be placed inside…

Mesoscale and Nanoscale Physics · Physics 2012-09-25 Anh D. Phan , Dustin A. Tracy , N. A. Viet

Decentralized diagnostic testing that is accurate, portable, quantitative, and capable of making multiple simultaneous measurements of different biomarkers at the point-of-need remains an important unmet need in the post-pandemic world.…

The mechanical behavior of any semiconductor microstructure is inevitably coupled to light. In the case of micro mechanical resonators (MEMs), carrier generation can affect the quality factor of the resonance through electron-phonon…

Applied Physics · Physics 2025-06-13 Ayelén Prado , Diego Perez-Morelo , Leonardo Salazar Alarcón , Hernán Pastoriza

The development of room-temperature sensing devices for detecting small concentrations of molecular species is imperative for a wide range of low-power sensor applications. We demonstrate a room-temperature, highly sensitive, selective, and…

We have demonstrated atomically thin, quantum capacitance-limited, field-effect transistors (FETs) that enable the detection of pH changes with ~75-fold higher sensitivity (4.4 V/pH) over the Nernst value of 59 mV/pH at room temperature…

The purpose of this paper is to apply characteristics of residual stress that causes cantilever beams to bend for manufacturing a micro-structured gas flow sensor. This study uses a silicon wafer deposited silicon nitride layers,…

Other Computer Science · Computer Science 2008-12-18 Y. -H. Wang , Tzu-Han Hsueh , Rong-Hua Ma , Chia-Yen Lee , Lung-Ming Fu , P. -Ch. Chou , Chien-Hsiung Tsai

Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA…

Soft Condensed Matter · Physics 2007-05-23 Ralf Metzler , Tobias Ambjoernsson

Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits.…

Optics · Physics 2016-11-15 N. P. Mauranyapin , L. S. Madsen , M. A. Taylor , M. Waleed , W. P. Bowen

We propose a conceptual device for multiplexed biosensor in a photonic crystal chip based on the Su-Schrieffer-Heeger mechanism. Remarkably, the proposed biosensor can identify three distinct disease markers through a single-shot photon…

Optics · Physics 2024-08-12 Yang Liu , Jian-Hua Jiang