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Partly motivated by entropy-estimation problems in neuroscience, we present a detailed and extensive comparison between some of the most popular and effective entropy estimation methods used in practice: The plug-in method, four different…

Information Theory · Computer Science 2015-05-13 Y. Gao , I. Kontoyiannis , E. Bienenstock

Sampling considerations limit the experimental conditions under which information theoretic analyses of neurophysiological data yield reliable results. We develop a procedure for computing the full temporal entropy and information of…

Biological Physics · Physics 2009-11-06 Simon R. Schultz , Stefano Panzeri

We consider the evolution of a network of neurons, focusing on the asymptotic behavior of spikes dynamics instead of membrane potential dynamics. The spike response is not sought as a deterministic response in this context, but as a…

Data Analysis, Statistics and Probability · Physics 2010-08-27 J. C. Vasquez , B. Cessac , T. Viéville

Neurons perform computations, and convey the results of those computations through the statistical structure of their output spike trains. Here we present a practical method, grounded in the information-theoretic analysis of prediction, for…

Neurons and Cognition · Quantitative Biology 2022-03-18 Robert Haslinger , Kristina Lisa Klinkner , Cosma Rohilla Shalizi

Quantification of information content and its temporal variation in intracellular calcium spike trains in neurons helps one understand functions such as memory, learning, and cognition. Such quantification could also reveal pathological…

Signal Processing · Electrical Eng. & Systems 2021-02-02 Sathish Ande , Srinivas Avasarala , Jayanth R Regatti , Neha Pandey , Sarpras Swain , Ajith Karunarathne , Lopamudra Giri , Soumya Jana

In many realistic systems, maximum entropy principle (MEP) analysis provides an effective characterization of the probability distribution of network states. However, to implement the MEP analysis, a sufficiently long-time data recording in…

Biological Physics · Physics 2019-02-27 Zhi-Qin John Xu , Jennifer Crodelle , Douglas Zhou , David Cai

The major problem in information theoretic analysis of neural responses and other biological data is the reliable estimation of entropy--like quantities from small samples. We apply a recently introduced Bayesian entropy estimator to…

Data Analysis, Statistics and Probability · Physics 2009-09-29 Ilya Nemenman , William Bialek , Rob de Ruyter van Steveninck

We propose a numerical method to learn Maximum Entropy (MaxEnt) distributions with spatio-temporal constraints from experimental spike trains. This is an extension of two papers [10] and [4] who proposed the estimation of parameters where…

Neurons and Cognition · Quantitative Biology 2015-06-19 Hassan Nasser , Bruno Cessac

Understanding the dynamics of neural networks is a major challenge in experimental neuroscience. For that purpose, a modelling of the recorded activity that reproduces the main statistics of the data is required. In a first part, we present…

Neurons and Cognition · Quantitative Biology 2014-04-15 Hassan Nasser , Olivier Marre , Bruno Cessac

Neurophysiologists are nowadays able to record from a large number of extracellular electrodes and to extract, from the raw data, the sequences of action potentials or spikes generated by many neurons. Unfortunately these ''many neurons''…

Applications · Statistics 2026-04-22 Pierre Charitat , Ségolen Geffray , Christophe Pouzat

Understanding how stimuli and synaptic connectivity in uence the statistics of spike patterns in neural networks is a central question in computational neuroscience. Maximum Entropy approach has been successfully used to characterize the…

Biological Physics · Physics 2016-11-26 Rodrigo Cofre , Bruno Cessac

This article contains two main theoretical results on neural spike train models. The first assumes that the spike train is modeled as a counting or point process on the real line where the conditional intensity function is a product of a…

Statistics Theory · Mathematics 2007-06-13 Hock Peng Chan , Wei-Liem Loh

Spiking activity from populations of neurons display causal interactions and memory effects. Therefore, they are expected to show some degree of irreversibility in time. Motivated by the spike train statistics, in this paper we build a…

Biological Physics · Physics 2015-12-07 Rodrigo Cofre , Cesar Maldonado

We briefly review and highlight the consequences of rigorous and exact results obtained in \cite{cessac:10}, characterizing the statistics of spike trains in a network of leaky Integrate-and-Fire neurons, where time is discrete and where…

Adaptation and Self-Organizing Systems · Physics 2010-08-31 Bruno Cessac , Hassan Nasser , Juan-Carlos Vasquez

We consider the maximum entropy Markov chain inference approach to characterize the collective statistics of neuronal spike trains, focusing on the statistical properties of the inferred model. We review large deviations techniques useful…

Neurons and Cognition · Quantitative Biology 2018-08-15 Rodrigo Cofre , Cesar Maldonado , Fernando Rosas

This work presents a novel means for understanding learning dynamics and scaling relations in neural networks. We show that certain measures on the spectrum of the empirical neural tangent kernel, specifically entropy and trace, yield…

Machine Learning · Computer Science 2024-10-11 Samuel Tovey , Sven Krippendorf , Michael Spannowsky , Konstantin Nikolaou , Christian Holm

Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $N\sim 100$ neurons. As $N$ increases in new…

Biological Physics · Physics 2023-10-18 Christopher W. Lynn , Qiwei Yu , Rich Pang , William Bialek , Stephanie E. Palmer

Understanding the interaction patterns among simultaneous recordings of spike trains from multiple neuronal units is a key topic in neuroscience. However, an optimal approach of assessing these interactions has not been established, as…

Neurons and Cognition · Quantitative Biology 2020-12-17 Gorana Mijatovic , Yuri Antonacci , Tatjana Loncar-Turukalo , Ludovico Minati , Luca Faes

In this paper we consider the problem of detecting statistically significant sequential patterns in multi-neuronal spike trains. These patterns are characterized by ordered sequences of spikes from different neurons with specific delays…

Neurons and Cognition · Quantitative Biology 2008-08-28 P. S. Sastry , K. P. Unnikrishnan

The mutual information between stimulus and spike-train response is commonly used to monitor neural coding efficiency, but neuronal computation broadly conceived requires more refined and targeted information measures of input-output joint…

Neurons and Cognition · Quantitative Biology 2015-04-21 Sarah E. Marzen , Michael R. DeWeese , James P. Crutchfield
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