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Our work is concerned with the generation and targeted design of RNA, a type of genetic macromolecule that can adopt complex structures which influence their cellular activities and functions. The design of large scale and complex…

Biomolecules · Quantitative Biology 2021-02-02 Zichao Yan , William L. Hamilton , Mathieu Blanchette

Graph are a ubiquitous data representation, as they represent a flexible and compact representation. For instance, the 3D structure of RNA can be efficiently represented as $\textit{2.5D graphs}$, graphs whose nodes are nucleotides and…

Machine Learning · Computer Science 2021-09-21 Vincent Mallet , Carlos G. Oliver , William L. Hamilton

Phylogenetic networks provide a general framework for modeling reticulate evolutionary processes such as hybridization, recombination, and horizontal gene transfer. In this paper, we study the asymptotic counting of binary phylogenetic…

Populations and Evolution · Quantitative Biology 2026-05-25 Hao Yu , Louxin Zhang

Grid diagrams with their relatively simple mathematical formalism provide a convenient way to generate and model projections of various knots. It has been an open question whether these 2D diagrams can be used to model a complex 3D process…

Biomolecules · Quantitative Biology 2019-09-16 Agnese Barbensi , Daniele Celoria , Heather A. Harrington , Andrzej Stasiak , Dorothy Buck

We characterize the graphs with loops whose degree sequences have no repeated values and find their adjacency spectrum. In the case of simple graphs, such graphs are called anti-regular graphs and are examples of threshold graphs. The…

Combinatorics · Mathematics 2019-12-16 Cesar O. Aguilar

A growing number of RNA sequences are now known to have distributions of multiple stable sequences. Recent algorithms use the list of nucleotides in a sequence and auxiliary experimental data to predict such distributions. Although the…

Combinatorics · Mathematics 2020-09-14 Torin Greenwood , Christine E. Heitsch

We present a linear-optical scheme for generation of an arbitrary state of three qubits. It requires only three independent particles in the input and post-selection of the coincidence-type at the output. The success probability of the…

Quantum Physics · Physics 2024-08-26 Pawel Blasiak , Ewa Borsuk , Marcin Markiewicz

In this paper we compute the limit distributions of the numbers of hairpin-loops, interior-loops and bulges in k-noncrossing RNA structures. The latter are coarse grained RNA structures allowing for cross-serial interactions, subject to the…

Combinatorics · Mathematics 2009-12-03 Markus E. Nebel , Christian M. Reidys , Rita R. Wang

Non-reciprocal interactions are among the simplest mechanisms that drive a physical system out of thermal equilibrium, leading to novel phenomena such as oscillatory pattern formation. In this paper, we introduce a ternary phase separation…

Soft Condensed Matter · Physics 2025-12-09 Xiao Ma , Michael E. Cates

Entanglement is a complexity measure of digraphs that origins in fixed-point logics. Its combinatorial purpose is to measure the nested depth of cycles in digraphs. We address the problem of characterizing the structure of graphs of…

Computer Science and Game Theory · Computer Science 2009-04-13 Walid Belkhir

In this paper, a selection of elegant, highly symmetric examples of three-periodic tangled nets and filaments are presented. They are constructed via familiar crystal nets using edges as geometric scaffolds for n-fold helical windings.…

Soft Condensed Matter · Physics 2026-03-31 Myfanwy E. Evans

Understanding phase diagrams is essential for material selection and design, as they provide a comprehensive representation of the thermodynamics of mixtures. This work delivers a broad and systematic overview of possible ternary phase…

Materials Science · Physics 2025-01-27 Yasin Ameslon , Hao Liu , Jens Harting , Olivier J. J. Ronsin , Olga Wodo

This paper develops the algebraic foundation required to build a Zariski-type geometry for \emph{commutative ternary $\Gamma$-semirings}, where multiplication is an inherently triadic, multi-parametric interaction…

Rings and Algebras · Mathematics 2025-12-25 Chandrasekhar Gokavarapu , D. Madhusudhana Rao

A graph is $k$-planar if it can be drawn in the plane such that no edge is crossed more than $k$ times. While for $k=1$, optimal $1$-planar graphs, i.e., those with $n$ vertices and exactly $4n-8$ edges, have been completely characterized,…

Computational Geometry · Computer Science 2017-03-21 Michael A. Bekos , Michael Kaufmann , Chrysanthi N. Raftopoulou

From the subsubleading chiral three-nucleon force [intermediate-range contributions, published in Phys. Rev. C\,87, 054007 (2013)] a density-dependent NN-interaction $V_\text{med}$ is derived in isospin-symmetric nuclear matter. Following…

Nuclear Theory · Physics 2021-02-01 N. Kaiser

Large RNA molecules often carry multiple functional domains whose spatial arrangement is an important determinant of their function. Pre-mRNA splicing, furthermore, relies on the spatial proximity of the splice junctions that can be…

Quantitative Methods · Quantitative Biology 2013-07-31 Rolf Backofen , Markus Fricke , Manja Marz , Jing Qin , Peter F. Stadler

We introduce kernel nonparametric tests for Lancaster three-variable interaction and for total independence, using embeddings of signed measures into a reproducing kernel Hilbert space. The resulting test statistics are straightforward to…

Methodology · Statistics 2013-06-11 Dino Sejdinovic , Arthur Gretton , Wicher Bergsma

The tertiary structures of functional RNA molecules remain difficult to decipher. A new generation of automated RNA structure prediction methods may help address these challenges but have not yet been experimentally validated. Here we apply…

Biomolecules · Quantitative Biology 2011-10-05 Wipapat Kladwang , Fang-Chieh Chou , Rhiju Das

In this paper, we characterize graphs with circular chromatic number less than 3 in terms of certain balancing labellings studied in the context of signed graphs. In fact, we construct a signed graph which is universal for all such…

Combinatorics · Mathematics 2025-12-09 Manuel Bodirsky , Santiago Guzmán-Pro , Moritz Jahn , Matěj Konečný , Paul Winkler

We describe a dynamic programming algorithm for predicting optimal RNA secondary structure, including pseudoknots. The algorithm has a worst case complexity of ${\cal O}(N^6)$ in time and ${\cal O}(N^4)$ in storage. The description of the…

Biological Physics · Physics 2009-09-25 Elena Rivas , Sean R. Eddy
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