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Natural supports of information are given by random copolymers such as DNA or RNA where information is coded in the sequence of covalent bonds. At the molecular scale, the stochastic growth of a single copolymer with or without a template…

Biomolecules · Quantitative Biology 2016-04-12 Pierre Gaspard

Ecological systems comprise an astonishing diversity of species that cooperate or compete with each other forming complex mutual dependencies. The minimum requirements to maintain a large species diversity on long time scales are in general…

Populations and Evolution · Quantitative Biology 2012-09-10 Joachim Mathiesen , Namiko Mitarai , Kim Sneppen , Ala Trusina

Natural language free-text explanation generation is an efficient approach to train explainable language processing models for commonsense-knowledge-requiring tasks. The most predominant form of these models is the explain-then-predict…

Computation and Language · Computer Science 2021-10-06 Myeongjun Jang , Thomas Lukasiewicz

Even though deep neural models have achieved superhuman performance on many popular benchmarks, they have failed to generalize to OOD or adversarial datasets. Conventional approaches aimed at increasing robustness include developing…

Machine Learning · Computer Science 2022-03-15 Swaroop Mishra , Anjana Arunkumar

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

Information Theory · Computer Science 2022-11-11 Ilan Shomorony , Reinhard Heckel

Whether the media faithfully communicate scientific information has long been a core issue to the science community. Automatically identifying paraphrased scientific findings could enable large-scale tracking and analysis of information…

Computation and Language · Computer Science 2022-10-25 Dustin Wright , Jiaxin Pei , David Jurgens , Isabelle Augenstein

Many living and physical systems such as cell aggregates, tissues or bacterial colonies behave as unconventional systems of particles that are strongly constrained by volume exclusion and shape interactions. Understanding how these…

Quantitative Methods · Quantitative Biology 2026-05-20 Antoine Diez , Jean Feydy

Large language models (LLMs) are increasingly expected to function as collaborative partners, engaging in back-and-forth dialogue to solve complex, ambiguous problems. However, current LLMs often falter in real-world settings, defaulting to…

Artificial Intelligence · Computer Science 2025-07-30 Tenghao Huang , Sihao Chen , Muhao Chen , Jonathan May , Longqi Yang , Mengting Wan , Pei Zhou

Open-ended question answering requires models to find appropriate evidence to form wellreasoned, comprehensive and helpful answers. In practical applications, models also need to engage in extended discussions on potential scenarios closely…

Computation and Language · Computer Science 2024-12-17 Mingxu Tao , Dongyan Zhao , Yansong Feng

The rise of multicellularity in the early evolution of life represents a major challenge for evolutionary biology. Guidance for finding answers has emerged from disparate fields, from phylogenetics to modelling and synthetic biology, but…

Populations and Evolution · Quantitative Biology 2015-11-09 Salva Duran-Nebreda , Adriano Bonforti , Raul Montañez , Sergi Valverde , Ricard Solé

Empirical evidence suggesting that living systems might operate in the vicinity of critical points, at the borderline between order and disorder, has proliferated in recent years, with examples ranging from spontaneous brain activity to…

Statistical Mechanics · Physics 2014-07-25 Jorge Hidalgo , Jacopo Grilli , Samir Suweis , Miguel A. Munoz , Jayanth R. Banavar , Amos Maritan

Let $\theta_0,\theta_1 \in \mathbb{R}^d$ be the population risk minimizers associated to some loss $\ell:\mathbb{R}^d\times \mathcal{Z}\to\mathbb{R}$ and two distributions $\mathbb{P}_0,\mathbb{P}_1$ on $\mathcal{Z}$. The models…

Statistics Theory · Mathematics 2021-07-13 Dmitrii M. Ostrovskii , Mohamed Ndaoud , Adel Javanmard , Meisam Razaviyayn

We assume that the state of a number of nodes in a network could be investigated if necessary, and study what configuration of those nodes could facilitate a better solution for the diffusion-source-localization (DSL) problem. In…

Social and Information Networks · Computer Science 2022-05-20 Yang Liu , Xiaoqi Wang , Xi Wang , Zhen Wang , Jürgen Kurths

Prototypical networks aim to build intrinsically explainable models based on the linear summation of concepts. Concepts are coherent entities that we, as humans, can recognize and associate with a certain object or entity. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Hugues Turbé , Mina Bjelogrlic , Gianmarco Mengaldo , Christian Lovis

Large language models (LLMs) make it plausible to build systems that improve through self-evolving loops, but many existing proposals are better understood as self-play and often plateau quickly. A central failure mode is that the loop…

Machine Learning · Computer Science 2026-05-19 Wei Liu , Siya Qi , Yali Du , Yulan He

Protein structure prediction has been a grand challenge for over 50 years, owing to its broad scientific and application interests. There are two primary types of modeling algorithms, template-free modeling and template-based modeling. The…

Biological Physics · Physics 2021-06-01 Liangzhen Zheng , Haidong Lan , Tao Shen , Jiaxiang Wu , Sheng Wang , Wei Liu , Junzhou Huang

The support recovery problem consists of determining a sparse subset of a set of variables that is relevant in generating a set of observations, and arises in a diverse range of settings such as compressive sensing, and subset selection in…

Information Theory · Computer Science 2016-08-31 Jonathan Scarlett , Volkan Cevher

According to the "hard-steps" model, the origin of humanity required "successful passage through a number of intermediate steps" (so-called "hard" or "critical" steps) that were intrinsically improbable with respect to the total time…

Populations and Evolution · Quantitative Biology 2025-02-18 Daniel B. Mills , Jennifer L. Macalady , Adam Frank , Jason T. Wright

The rapid spread of misinformation on online platforms undermines trust among individuals and hinders informed decision making. This paper shows an explainable and computationally efficient pipeline to detect misinformation using…

Computation and Language · Computer Science 2025-10-23 Jainee Patel , Chintan Bhatt , Himani Trivedi , Thanh Thi Nguyen

Speciation is fundamental to the huge diversity of life on Earth. Evidence suggests reproductive isolation arises most commonly in allopatry with a higher speciation rate in small populations. Current theory does not address this dependence…

Populations and Evolution · Quantitative Biology 2015-03-27 Bhavin S. Khatri , Richard A. Goldstein