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Comprehensive, synapse-resolution imaging of the brain will be crucial for understanding neuronal computations and function. In connectomics, this has been the sole purview of volume electron microscopy (EM), which entails an excruciatingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Yicong Li , Yaron Meirovitch , Aaron T. Kuan , Jasper S. Phelps , Alexandra Pacureanu , Wei-Chung Allen Lee , Nir Shavit , Lu Mi

Scanning Transmission Electron Microscopy (STEM) offers high-resolution images that are used to quantify the nanoscale atomic structure and composition of materials and biological specimens. In many cases, however, the resolution is limited…

Signal Processing · Electrical Eng. & Systems 2021-12-23 Daniel Nicholls , Alex Robinson , Jack Wells , Amirafshar Moshtaghpour , Mounib Bahri , Angus Kirkland , Nigel Browning

It has been argued that in atomic-resolution transmission electron microscopy (TEM) of sparse weakly scattering structures, such as small biological molecules, multiple electron scattering usually has only a small effect, while the…

Optics · Physics 2021-11-16 T. E. Gureyev , H. M. Quiney , A. Kozlov , D. M. Paganin , G. Schmalz , L. J. Allen

We introduce a framework for recovering an image from its rotationally and translationally invariant features based on autocorrelation analysis. This work is an instance of the multi-target detection statistical model, which is mainly used…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Nicholas F. Marshall , Ti-Yen Lan , Tamir Bendory , Amit Singer

The transmission electron microscope facilitates the highest-resolution imaging of any instrument ever created, and its limiting factor is no longer spatial resolution but dose efficiency. Low electron doses avoid sample damage but produce…

Machine Learning · Computer Science 2026-05-08 Georgia Channing , Debora Keller , Marta D. Rossell , Philip Torr , Stig Helveg , Henrik Eliasson

SPECT (Single-photon Emission Computerized Tomography) and PET (Positron Emission Tomography) are essential medical imaging tools, for which the sampling angle number, scan time should be chosen carefully to compromise between image quality…

Medical Physics · Physics 2015-06-16 Xiaolin Zhou , Minkai Yun , Xuexiang Cao , Shuangquan Liu , Lu Wang , Xianchao Huang , Long Wei

In this study, we present a large-scale earth surface reconstruction pipeline for linear-array charge-coupled device (CCD) satellite imagery. While mainstream satellite image-based reconstruction approaches perform exceptionally well, the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Hong Danyang , Yu Anzhu , Ji Song , Cao Xuefeng , Quan Yujun , Guo Wenyue , Qiu Chunping

We present a new method for reconstructing two-dimensional mass maps of galaxy clusters from the image distortion of background galaxies. In contrast to most previous approaches, which directly convert locally averaged image ellipticities…

Astrophysics · Physics 2007-05-23 Stella Seitz , Peter Schneider , Matthias Bartelmann

Cryo-electron microscopy (cryo-EM) has become a central tool for high-resolution structural biology, yet the massive scale of datasets (often exceeding 100k particle images) renders 3D reconstruction both computationally expensive and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Huaizhi Qu , Xiao Wang , Gengwei Zhang , Jie Peng , Tianlong Chen

We present a Maximum Entropy method (MEM) for obtaining dynamical spectra from Quantum Monte Carlo data which have a sign problem. By relating the sign fluctuations to the norm of the spectra, our method properly treats the correlations…

Statistical Mechanics · Physics 2007-05-23 A. Macridin , S. P. Doluweera , M. Jarrell , Th. Maier

Cryo-electron microscopy (EM) single particle reconstruction is an entirely general technique for 3D structure determination of macromolecular complexes. However, because the images are taken at low electron dose, it is extremely hard to…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Yifeng Fan , Zhizhen Zhao

EGRET data are usually analysed on the basis of the Maximum-Likelihood method \cite{ma96} in a search for point sources in excess to a model for the background radiation (e.g. \cite{hu97}). This method depends strongly on the quality of the…

Astrophysics · Physics 2009-10-30 Martin Pohl

Alternative reconstruction method is proposed on retrieving the object exit wave function (OEW) directly from the recorded image intensity pattern in high resolution transmission electron microscopy (HRTEM). The method is based on applying…

Materials Science · Physics 2021-03-02 Usha Bhat , Ranjan Datta

We explore a method of statistical estimation called Maximum Entropy on the Mean (MEM) which is based on an information-driven criterion that quantifies the compliance of a given point with a reference prior probability measure. At the core…

Statistics Theory · Mathematics 2022-12-20 Yakov Vaisbourd , Rustum Choksi , Ariel Goodwin , Tim Hoheisel , Carola-Bibiane Schönlieb

We investigate the recovery of structures from large-area, low dose exposures that distribute the dose over many identical copies of an object. The reconstruction is done via a maximum likelihood approach that does neither require to…

Materials Science · Physics 2018-03-28 C. Kramberger , J. C. Meyer

Muon tomography is a relatively new method of radiography that utilizes muons from cosmic rays and their multiple Coulomb scattering property to distinguish materials. Researchers around the world have been developing various detection…

Instrumentation and Detectors · Physics 2019-12-20 Weihe Zeng , Xingyu Pan , Zhi Zeng , Hao Ma , Ming Zeng , Jianping Cheng

Cryo-electron microscopy (cryo-EM) has achieved near-atomic level resolution of biomolecules by reconstructing 2D micrographs. However, the resolution and accuracy of the reconstructed particles are significantly reduced due to the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Jing Zhang , Tengfei Zhao , ShiYu Hu , Xin Zhao

A central problem in neuroscience is reconstructing neuronal circuits on the synapse level. Due to a wide range of scales in brain architecture such reconstruction requires imaging that is both high-resolution and high-throughput. Existing…

Computer Vision and Pattern Recognition · Computer Science 2012-10-03 Tao Hu , Juan Nunez-Iglesias , Shiv Vitaladevuni , Lou Scheffer , Shan Xu , Mehdi Bolorizadeh , Harald Hess , Richard Fetter , Dmitri Chklovskii

Advances in instrumentation and computation have enabled increasingly sophisticated tomographic reconstruction methods. However, existing evaluation practices -- often based on simple phantoms and global image metrics -- are limited in…

Medical Physics · Physics 2026-04-06 Anna Frixou , Theodoros Leontiou , Efstathios Stiliaris , Costas N. Papanicolas

Image deblurring is a notoriously challenging ill-posed inverse problem. In recent years, a wide variety of approaches have been proposed based upon regularization at the level of the image or on techniques from machine learning. We propose…

Computer Vision and Pattern Recognition · Computer Science 2020-10-22 Gabriel Rioux , Rustum Choksi , Tim Hoheisel , Pierre Marechal , Christopher Scarvelis
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