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We present an optimized conductance-based retina microcircuit simulator which transforms light stimuli into a series of graded and spiking action potentials through photo transduction. We use discrete retinal neuron blocks based on a…

Neurons and Cognition · Quantitative Biology 2020-01-16 Jason K. Eshraghian , Seungbum Baek , Wesley Thio , Yulia Sandamirskaya , Herbert H. C. Iu , Wei D. Lu

According to the theory of efficient coding, sensory systems are adapted to represent natural scenes with high fidelity and at minimal metabolic cost. Testing this hypothesis for sensory structures performing non-linear computations on high…

Neurons and Cognition · Quantitative Biology 2018-04-13 Ulisse Ferrari , Christophe Gardella , Olivier Marre , Thierry Mora

Spike generation in neurons produces a temporal point process, whose statistics is governed by intrinsic phenomena and the external incoming inputs to be coded. In particular, spike-evoked adaptation currents support a slow temporal process…

Neurons and Cognition · Quantitative Biology 2016-10-31 Eugenio Urdapilleta

The computation performed by a neuron can be formulated as a combination of dimensional reduction in stimulus space and the nonlinearity inherent in a spiking output. White noise stimulus and reverse correlation (the spike-triggered average…

Biological Physics · Physics 2007-05-23 Blaise Aguera y Arcas , Adrienne Fairhall

Neurons in the central nervous system communicate with each other with the help of series of Action Potentials, or spike trains. Various studies have shown that neurons encode information in different features of spike trains, such as the…

Neurons and Cognition · Quantitative Biology 2014-10-21 Shubhanshu Shekhar , Kaushik Majumdar

Multielectrode arrays allow recording of the activity of many single neurons, from which correlations can be calculated. The functional roles of correlations can be revealed by the measures of the information conveyed by neuronal activity;…

Statistical Mechanics · Physics 2009-09-25 Michele Bezzi , Mathew E. Diamond , Alessandro Treves

Multi-electrode arrays covering several square millimeters of neural tissue provide simultaneous access to population signals such as extracellular potentials and spiking activity of one hundred or more individual neurons. The…

Neurons and Cognition · Quantitative Biology 2024-11-11 Johanna Senk , Espen Hagen , Sacha J. van Albada , Markus Diesmann

Adaptation in the retina is thought to optimize the encoding of natural light signals into sequences of spikes sent to the brain. However, adaptation also entails computational costs: adaptive code is intrinsically ambiguous, because output…

Neurons and Cognition · Quantitative Biology 2014-01-28 Gašper Tkačik , Anandamohan Ghosh , Elad Schneidman , Ronen Segev

Recent studies have shown how spiking networks can learn complex functionality through error-correcting plasticity, but the resulting structures and dynamics remain poorly studied. To elucidate how these models may link to observed dynamics…

Neurons and Cognition · Quantitative Biology 2025-08-19 Jonas Oberste-Frielinghaus , Anno C. Kurth , Julian Göltz , Laura Kriener , Junji Ito , Mihai A. Petrovici , Sonja Grün

Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant…

Neurons and Cognition · Quantitative Biology 2007-05-23 Ilya Nemenman , Geoffrey D. Lewen , William Bialek , Rob R. de Ruyter van Steveninck

Spike Timing Dependent Plasticity is form of learning that has been demonstrated in real cortical tissue, but attempts to use it for artificial systems have not produced good results. This paper seeks to remedy this with two significant…

Neural and Evolutionary Computing · Computer Science 2020-07-01 Simon Davidson , Stephen B. Furber , Oliver Rhodes

Information needs to be appropriately encoded to be reliably transmitted over physical media. Similarly, neurons have their own codes to convey information in the brain. Even though it is well-known that neurons exchange information using a…

Neurons and Cognition · Quantitative Biology 2018-10-18 Chris G. Antonopoulos , Ezequiel Bianco-Martinez , Murilo S. Baptista

The timing of individual neuronal spikes is essential for biological brains to make fast responses to sensory stimuli. However, conventional artificial neural networks lack the intrinsic temporal coding ability present in biological…

Neural and Evolutionary Computing · Computer Science 2020-11-18 Iulia M. Comsa , Krzysztof Potempa , Luca Versari , Thomas Fischbacher , Andrea Gesmundo , Jyrki Alakuijala

The activity of neurons within brain circuits has been ubiquitously reported to be correlated. The impact of these correlations on brain function has been extensively investigated. Correlations can in principle increase or decrease the…

Neurons and Cognition · Quantitative Biology 2025-07-24 Miguel Ibáñez-Berganza , Giulio Bondanelli , Stefano Panzeri

We consider a model of basic inner retinal connectivity where bipolar and amacrine cells interconnect, and both cell types project onto ganglion cells, modulating their response output to the brain visual areas. We derive an analytical…

Neurons and Cognition · Quantitative Biology 2024-01-10 Evgenia Kartsaki , Gerrit Hilgen , Evelyne Sernagor , Bruno Cessac

The functional significance of correlations between action potentials of neurons is still a matter of vivid debates. In particular it is presently unclear how much synchrony is caused by afferent synchronized events and how much is…

Neurons and Cognition · Quantitative Biology 2013-04-09 Matthias Schultze-Kraft , Markus Diesmann , Sonja Grün , Moritz Helias

The mutual information between stimulus and spike-train response is commonly used to monitor neural coding efficiency, but neuronal computation broadly conceived requires more refined and targeted information measures of input-output joint…

Neurons and Cognition · Quantitative Biology 2015-04-21 Sarah E. Marzen , Michael R. DeWeese , James P. Crutchfield

Correlations in spike-train ensembles can seriously impair the encoding of information by their spatio-temporal structure. An inevitable source of correlation in finite neural networks is common presynaptic input to pairs of neurons. Recent…

Neurons and Cognition · Quantitative Biology 2015-06-04 Tom Tetzlaff , Moritz Helias , Gaute T. Einevoll , Markus Diesmann

Repeating spatiotemporal spike patterns exist and carry information. Here we investigated how a single spiking neuron can optimally respond to one given pattern (localist coding), or to either one of several patterns (distributed coding,…

Neural and Evolutionary Computing · Computer Science 2018-09-24 Timothée Masquelier , Saeed Reza Kheradpisheh

Generalized linear models are one of the most efficient paradigms for predicting the correlated stochastic activity of neuronal networks in response to external stimuli, with applications in many brain areas. However, when dealing with…

Disordered Systems and Neural Networks · Physics 2020-11-17 Gabriel Mahuas , Giulio Isacchini , Olivier Marre , Ulisse Ferrari , Thierry Mora