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In certain privacy-sensitive scenarios within fields such as clinical trial simulations, federated learning, and distributed learning, researchers often face the challenge of estimating correlations between variables without access to…

Methodology · Statistics 2025-08-05 Longwen Shang , Min Tsao , Xuekui Zhang

This paper provides further insight into the key concept of missing at random (MAR) in incomplete data analysis. Following the usual selection modelling approach we envisage two models with separable parameters: a model for the response of…

Statistics Theory · Mathematics 2007-06-13 Guobing Lu , John B. Copas

The interplay between missing data and model uncertainty -- two classic statistical problems -- leads to primary questions that we formally address from an objective Bayesian perspective. For the general regression problem, we discuss the…

A probabilistic query may not be estimable from observed data corrupted by missing values if the data are not missing at random (MAR). It is therefore of theoretical interest and practical importance to determine in principle whether a…

Machine Learning · Statistics 2016-11-16 Jin Tian

We develop a novel approach to tackle the common but challenging problem of conformal inference for missing data in machine learning, focusing on Missing at Random (MAR) data. We propose a new procedure Conformal prediction for Missing data…

Methodology · Statistics 2025-10-22 Wenlu Tang , Hongni Wang , Xingcai Zhou , Bei Jiang , Linglong Kong

The problem of monotone missing data has been broadly studied during the last two decades and has many applications in different fields such as bioinformatics or statistics. Commonly used imputation techniques require multiple iterations…

Machine Learning · Computer Science 2020-09-25 Thu Nguyen , Duy H. M. Nguyen , Huy Nguyen , Binh T. Nguyen , Bruce A. Wade

Multiple root estimation problems in statistical inference arise in many contexts in the literature. In the context of maximum likelihood estimation, the existence of multiple roots causes uncertainty in the computation of maximum…

Statistics Theory · Mathematics 2017-02-16 Elizabeth Gross , Sonja Petrović , Donald Richards , Despina Stasi

Data collected in clinical trials are often composed of multiple types of variables. For example, laboratory measurements and vital signs are longitudinal data of continuous or categorical variables, adverse events may be recurrent events,…

Methodology · Statistics 2023-01-12 Tuo Wang , Rachel Zilinskas , Ying Li , Yongming Qu

We consider the problem of full information maximum likelihood (FIML) estimation in a factor analysis model when a majority of the data values are missing. The expectation-maximization (EM) algorithm is often used to find the FIML…

Computation · Statistics 2013-12-20 Kei Hirose , Sunyong Kim , Yutaka Kano , Miyuki Imada , Manabu Yoshida , Masato Matsuo

Missing data is a ubiquitous challenge in data analysis, often leading to biased and inaccurate results. Traditional imputation methods usually assume that the missingness mechanism is missing-at-random (MAR), where the missingness is…

Methodology · Statistics 2026-03-30 Huiming Xie , Fei Xue , Xiao Wang

Maximum likelihood estimation (MLE) is a fundamental computational problem in statistics. The problem is to maximize the likelihood function with respect to given data on a statistical model. An algebraic approach to this problem is to…

Symbolic Computation · Computer Science 2015-05-07 Jose Israel Rodriguez , Xiaoxian Tang

Maximum likelihood estimation is a fundamental optimization problem in statistics. We study this problem on manifolds of matrices with bounded rank. These represent mixtures of distributions of two independent discrete random variables. We…

Algebraic Geometry · Mathematics 2013-03-19 Jonathan Hauenstein , Jose Rodriguez , Bernd Sturmfels

This paper reviews recent advances in missing data research using graphical models to represent multivariate dependencies. We first examine the limitations of traditional frameworks from three different perspectives: \textit{transparency,…

Methodology · Statistics 2019-11-15 Karthika Mohan , Judea Pearl

Commonly used methods to analyze incomplete longitudinal clinical trial data include complete case analysis (CC) and last observation carried forward (LOCF). However, such methods rest on strong assumptions, including missing completely at…

Statistics Theory · Mathematics 2007-06-13 Ivy Jansen , Caroline Beunckens , Geert Molenberghs , Geert Verbeke , Craig Mallinckrodt

Missing data occur frequently in a wide range of applications. In this paper, we consider estimation of high-dimensional covariance matrices in the presence of missing observations under a general missing completely at random model in the…

Methodology · Statistics 2016-05-17 T. Tony Cai , Anru Zhang

Missing observations are common in cluster randomised trials. Approaches taken to handling such missing data include: complete case analysis, single-level multiple imputation that ignores the clustering, multiple imputation with a fixed…

Methodology · Statistics 2014-07-18 Karla Diaz-Ordaz , Michael G. Kenward , Manuel Gomes , Richard Grieve

A very simple interpretation of matrix completion problem is introduced based on statistical models. Combined with the well-known results from missing data analysis, such interpretation indicates that matrix completion is still a valid and…

Machine Learning · Statistics 2016-05-11 Tianxi Li

Multiple imputation (MI) has become one of the main procedures used to treat missing data, but the guidelines from the methodological literature are not easily transferred to multilevel research. For models including random slopes, proper…

Methodology · Statistics 2016-06-30 Simon Grund , Oliver Lüdtke , Alexander Robitzsch

For general data, the number of complex solutions to the likelihood equations is constant and this number is called the (maximum likelihood) ML-degree of the model. In this article, we describe the special locus of data for which the…

Algebraic Geometry · Mathematics 2015-10-01 Emil Horobet , Jose Israel Rodriguez

The problem of completing a large matrix with lots of missing entries has received widespread attention in the last couple of decades. Two popular approaches to the matrix completion problem are based on singular value thresholding and…

Statistics Theory · Mathematics 2022-04-25 Sohom Bhattacharya , Sourav Chatterjee