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While renormalization groups are fundamental in physics, renormalization of complex networks remains vague in its conceptual definition and methodology. Here, we propose a novel strategy to renormalize complex networks. Rather than…

Statistical Mechanics · Physics 2024-03-13 Sungwon Jung , Sang Hoon Lee , Jaeyoon Cho

The analysis of networks characterized by links with heterogeneous intensity or weight suffers from two long-standing problems of arbitrariness. On one hand, the definitions of topological properties introduced for binary graphs can be…

Data Analysis, Statistics and Probability · Physics 2014-04-28 Diego Garlaschelli , Sebastian E. Ahnert , Thomas M. A. Fink , Guido Caldarelli

The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modular topology of the molecular…

Molecular Networks · Quantitative Biology 2007-09-07 Jing Zhao , Guo-Hui Ding , Lin Tao , Hong Yu , Zhong-Hao Yu , Jian-Hua Luo , Zhi-Wei Cao , Yi-Xue Li

This paper serves as a framework for designing advanced models for drug action on metabolism. Drug treatment may affect metabolism by either enhancing or inhibiting metabolic reactions comprising a metabolic network. We introduce the…

Molecular Networks · Quantitative Biology 2020-03-30 Sean T. McQuade , Nathaniel J. Merrill , Benedetto Piccoli

Biochemical networks are used in computational biology, to model the static and dynamical details of systems involved in cell signaling, metabolism, and regulation of gene expression. Parametric and structural uncertainty, as well as…

Molecular Networks · Quantitative Biology 2014-10-15 Ovidiu Radulescu , Alexander N. Gorban , Andrei Zinovyev , Vincent Noel

We reply to the recent note "Comment on Synchronization dynamics in non-normal networks: the trade-off for optimality", showing that the authors base their claims mainly on general theoretical arguments that do not necessarily invalidate…

Adaptation and Self-Organizing Systems · Physics 2022-06-20 Riccardo Muolo , Timoteo Carletti , James P. Gleeson , Malbor Asllani

Genetic regulatory networks are defined by their topology and by a multitude of continuously adjustable parameters. Here we present a class of simple models within which the relative importance of topology vs. interaction strengths becomes…

Molecular Networks · Quantitative Biology 2013-08-02 Mikhail Tikhonov , William Bialek

Formation of a molecular network from multifunctional precursors is modelled with a random graph process. The random graph model favours reactivity for monomers that are positioned close in the network topology, and disfavours reactivity…

Soft Condensed Matter · Physics 2019-08-21 Ivan Kryven , Jorien Duivenvoorden , Joen Hermans , Piet D. Iedema

A recent article by Weidner et al. [2021] presents a method to extract graph properties that are predictive of the dynamical behavior of multivariate, discrete models of biochemical regulation. In other words, a method that uses only…

Quantitative Methods · Quantitative Biology 2021-10-22 Luis M. Rocha

The recent paper by W.-X. Wang, Y.-C. Lai, J. Ren, B. Li & C. Grebogi [arXiv:1107.2177v1] proposed a method for the control of complex networks with nonlinear dynamics based on linearizing the system around a finite number of local desired…

Disordered Systems and Neural Networks · Physics 2011-09-01 Jie Sun , Sean P. Cornelius , William L. Kath , Adilson E. Motter

Functional complex networks have meant a pivotal change in the way we understand complex systems, being the most outstanding one the human brain. These networks have classically been reconstructed using a frequentist approach that, while…

Data Analysis, Statistics and Probability · Physics 2018-03-14 Massimiliano Zanin , Seddik Belkoura , Javier Gomez , Cesar Alfaro , Javier Cano

Modularity is a quantity which has been introduced in the context of complex networks in order to quantify how close a network is to an ideal modular network in which the nodes form small interconnected communities that are joined together…

Probability · Mathematics 2021-04-05 Jordan Chellig , Nikolaos Fountoulakis , Fiona Skerman

Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action kinetics, the dynamics of these chemical reaction networks are governed by systems…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston

We present a simple model of network dynamics that can be solved analytically for uniform networks. We obtain the dynamics of response of the system to perturbations. The analytical solution is an excellent approximation for random…

Cellular Automata and Lattice Gases · Physics 2009-11-11 M. A. M. de Aguiar , Irving R. Epstein , Yaneer Bar-Yam

Many modern networks are \emph{reconfigurable}, in the sense that the topology of the network can be changed by the nodes in the network. For example, peer-to-peer, wireless and ad-hoc networks are reconfigurable. More generally, many…

Data Structures and Algorithms · Computer Science 2013-05-22 Amitabh Trehan

We cast the metabolism of interacting cells within a statistical mechanics framework considering both, the actual phenotypic capacities of each cell and its interaction with its neighbors. Reaction fluxes will be the components of…

Molecular Networks · Quantitative Biology 2020-04-08 Jorge Fernandez-de-Cossio-Diaz , Roberto Mulet

A plethora of computational models have been developed in recent decades to account for the morphogenesis of complex biological fluid networks, such as capillary beds. Contemporary adaptation models are based on optimization schemes where…

Tissues and Organs · Quantitative Biology 2021-11-16 Felix Kramer , Carl D. Modes

This article is addressing a recurrent problem in biology: mining newly built large scale networks. Our approach consists in comparing these new networks to well known ones. The visual backbone of this comparative analysis is provided by a…

Quantitative Methods · Quantitative Biology 2008-12-05 Romain Bourqui , Fabien Jourdan

Biological and social networks have recently attracted enormous attention between physicists. Among several, two main aspects may be stressed: A non trivial topology of the graph describing the mutual interactions between agents exists…

Statistical Mechanics · Physics 2015-05-19 Adriano Barra , Elena Agliari

The topology of many real complex networks has been conjectured to be embedded in hidden metric spaces, where distances between nodes encode their likelihood of being connected. Besides of providing a natural geometrical interpretation of…

Physics and Society · Physics 2017-01-23 Antoine Allard , M. Ángeles Serrano , Guillermo García-Pérez , Marián Boguñá