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A model is proposed to minimize the total volume of the main distribution networks of fluids in organs such as the kidney and the lung. A consequence of the minimization analysis is that the optimal overall form of the organs is a modified…

Tissues and Organs · Quantitative Biology 2007-05-23 Walton R. Gutierrez

The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that…

Tissues and Organs · Quantitative Biology 2023-01-19 Timothy L. Kline

At the basic geometric level, the distribution networks carrying vital materials in living organisms, and the units such as the nephrons and alveoli, form a scaling structure named here the site model. This unified view of the allometry of…

Tissues and Organs · Quantitative Biology 2007-05-23 Walton R. Gutierrez

Biological transport networks are highly optimized structures that ensure power-efficient distribution of fluids across various domains, including animal vasculature and plant venation. Theoretically, these networks can be described as…

Biological Physics · Physics 2025-08-01 Albert Alonso , Lars Erik J. Skjegstad , Julius B. Kirkegaard

Highly-optimized complex transport networks serve crucial functions in many man-made and natural systems such as power grids and plant or animal vasculature. Often, the relevant optimization functional is non-convex and characterized by…

Biological Physics · Physics 2016-09-23 Henrik Ronellenfitsch , Eleni Katifori

Can three-dimensional, microvasculature networks still ensure blood supply if individual links fail? We address this question in the sinusoidal network, a plexus-like microvasculature network, which transports nutrient-rich blood to every…

Many foraging microorganisms rely upon cellular transport networks to deliver nutrients, fluid and organelles between different parts of the organism. Networked organisms ranging from filamentous fungi to slime molds demonstrate a…

Adaptation and Self-Organizing Systems · Physics 2020-12-08 Cassidy Mentus , Marcus Roper

The renal vasculature, acting as a resource distribution network, plays an important role in both the physiology and pathophysiology of the kidney. However, no imaging techniques allow an assessment of the structure and function of the…

Computational Engineering, Finance, and Science · Computer Science 2023-05-11 Peidi Xu , Niels-Henrik Holstein-Rathlou , Stinne Byrholdt Søgaard , Carsten Gundlach , Charlotte Mehlin Sørensen , Kenny Erleben , Olga Sosnovtseva , Sune Darkner

Physical networks are made of nodes and links that are physical objects embedded in a geometric space. Understanding how the mutual volume exclusion between these elements affects the structure and function of physical networks calls for a…

Statistical Mechanics · Physics 2024-06-14 Gábor Pete , Ádám Timár , Sigurdur Örn Stefánsson , Ivan Bonamassa , Márton Pósfai

We study spatial networks that are designed to distribute or collect a commodity, such as gas pipelines or train tracks. We focus on the cost of a network, as represented by the total length of all its edges, and its efficiency in terms of…

Disordered Systems and Neural Networks · Physics 2007-05-23 Michael T. Gastner , M. E. J. Newman

Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…

Cardiovascular networks span the body by branching across many generations of vessels. The resulting structure delivers blood over long distances to supply all cells with oxygen via the relatively short-range process of diffusion at the…

Medical Physics · Physics 2016-06-15 David Hunt , Van M. Savage

Within animals, oxygen exchange occurs within networks containing potentially billions of microvessels that are distributed throughout the animal's body. Innovative imaging methods now allow for mapping of the architecture and blood flows…

Quantitative Methods · Quantitative Biology 2017-09-28 Shyr-Shea Chang , Marcus Roper

Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically…

Tissues and Organs · Quantitative Biology 2015-12-22 Richard J. McMurtrey

Distribution networks -- from vasculature to urban transportation systems -- are prevalent in both the natural and consumer worlds. These systems are intrinsically physical in composition and are embedded into real space, properties that…

Quantitative Methods · Quantitative Biology 2016-12-26 Lia Papadopoulos , Pablo Blinder , Henrik Ronellenfitsch , Florian Klimm , Eleni Katifori , David Kleinfeld , Danielle S. Bassett

Properties of networks are often characterized in terms of features such as node degree distributions, average path lengths, diameters, or clustering coefficients. Here, we study shortest path length distributions. On the one hand, average…

Social and Information Networks · Computer Science 2015-01-20 Christian Bauckhage , Kristian Kersting , Fabian Hadiji

Vascular networks are used across the kingdoms of life to transport fluids, nutrients and cellular material. A popular unifying idea for understanding the diversity and constraints of these networks is that the conduits making up the…

Optimization and Control · Mathematics 2017-09-13 Shyr-Shea Chang , Marcus Roper

Kidney volume is greatly affected in several renal diseases. Precise and automatic segmentation of the kidney can help determine kidney size and evaluate renal function. Fully convolutional neural networks have been used to segment organs…

Image and Video Processing · Electrical Eng. & Systems 2020-09-02 Omid Bazgir , Kai Barck , Richard A. D. Carano , Robby M. Weimer , Luke Xie

The structure of pipe networks minimizing the total energy dissipation rate is studied analytically. Among all the possible pipe networks that can be built with a given total pipe volume (or pipe lateral surface area), the network which…

Disordered Systems and Neural Networks · Physics 2010-09-08 Marc Durand

The outer Lowner-John method is widely used in sensor fusion applications to find the smallest ellipsoid that can approximate the intersection of a set of ellipsoids, described by positive definite covariance matrices modeling the quality…

Systems and Control · Electrical Eng. & Systems 2023-05-25 Rodrigo Aldana-Lopez , Eduardo Sebastian , Rosario Aragues , Eduardo Montijano , Carlos Sagues
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