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We present a sparse knowledge gradient (SpKG) algorithm for adaptively selecting the targeted regions within a large RNA molecule to identify which regions are most amenable to interactions with other molecules. Experimentally, such regions…

Optimization and Control · Mathematics 2015-08-10 Yan Li , Kristofer G. Reyes , Jorge Vazquez-Anderson , Yingfei Wang , Lydia M. Contreras , Warren B. Powell

We investigate how individuals form expectations about population behavior using statistical inference based on observations of their social relations. Misperceptions about others' connectedness and behavior arise from sampling bias…

Theoretical Economics · Economics 2022-05-27 Andreas Bjerre-Nielsen , Martin Benedikt Busch

This paper develops conformal inference methods to construct a confidence interval for the frequency of a queried object in a very large discrete data set, based on a sketch with a lower memory footprint. This approach requires no knowledge…

Methodology · Statistics 2023-08-17 Matteo Sesia , Stefano Favaro , Edgar Dobriban

Respondent-Driven Sampling (RDS) is an approach to sampling design and inference in hard-to-reach human populations. Typically, a sampling frame is not available, and population members are difficult to identify or recruit from broader…

Methodology · Statistics 2012-09-28 Mark S. Handcock , Krista J. Gile , Corinne M. Mar

In statistical exercises where there are several candidate models, the traditional approach is to select one model using some data driven criterion and use that model for estimation, testing and other purposes, ignoring the variability of…

Statistics Theory · Mathematics 2008-12-18 Snigdhansu Chatterjee , Nitai D. Mukhopadhyay

Markovian population models are suitable abstractions to describe well-mixed interacting particle systems in situation where stochastic fluctuations are significant due to the involvement of low copy particles. In molecular biology,…

Quantitative Methods · Quantitative Biology 2014-01-17 Christoph Zechner , Federico Wadehn , Heinz Koeppl

Objectives: Estimation of areas under receiver operating characteristic curves (AUCs) and their differences is a key task in diagnostic studies. We aimed to derive, evaluate, and implement simple sample size formulas for such studies with a…

Methodology · Statistics 2022-08-03 Di Shu , Guangyong Zou

Statistical inference for large data panels is omnipresent in modern economic applications. An important benefit of panel analysis is the possibility to reduce noise and thus to guarantee stable inference by intersectional pooling. However,…

Methodology · Statistics 2022-12-15 Tim Kutta , Holger Dette

Monte Carlo methods to evaluate and maximize the likelihood function enable the construction of confidence intervals and hypothesis tests, facilitating scientific investigation using models for which the likelihood function is intractable.…

Methodology · Statistics 2017-02-13 Edward L. Ionides , Carles Breto , Joonha Park , Richard A. Smith , Aaron A. King

A tremendous amount of individual-level data is generated each day, of use to marketing, decision makers, and machine learning applications. This data often contain private and sensitive information about individuals, which can be disclosed…

Cryptography and Security · Computer Science 2019-01-23 Marmar Orooji , Gerald M. Knapp

The network scale-up method enables researchers to estimate the size of hidden populations, such as drug injectors and sex workers, using sampled social network data. The basic scale-up estimator offers advantages over other size estimation…

Applications · Statistics 2016-11-14 Dennis M. Feehan , Matthew J. Salganik

It is becoming routine to obtain datasets on DNA sequence variation across several thousands of chromosomes, providing unprecedented opportunity to infer the underlying biological and demographic forces. Such data make it vital to study…

Populations and Evolution · Quantitative Biology 2015-06-24 Paul A. Jenkins , Jonas W. Mueller , Yun S. Song

Small cells are one of the solutions to face the imperative demand on increasing mobile data traffic. They are low-powered base stations installed close to the users to offer better network services and to deal with increased data traffic.…

Signal Processing · Electrical Eng. & Systems 2018-11-07 Amirreza Chobineh , Yuanyuan Huang , Taghrid Mazloum , Emmanuelle Conil , Joe Wiart

The processes taking place inside the living cell are now understood to the point where predictive computational models can be used to gain detailed understanding of important biological phenomena. A key challenge is to extrapolate this…

Tissues and Organs · Quantitative Biology 2018-10-26 Stefan Engblom Daniel B. Wilson , Ruth E. Baker

Respondent-driven sampling (RDS) is a popular method for sampling hard-to-survey populations that leverages social network connections through peer recruitment. While RDS is most frequently applied to estimate the prevalence of infections…

Methodology · Statistics 2016-10-24 Ashton M. Verdery , Jacob C. Fisher , Nalyn Siripong , Kahina Abdesselam , Shawn Bauldry

Background: Current neuronal monitoring techniques, such as calcium imaging and multi-electrode arrays, enable recordings of spiking activity from hundreds of neurons simultaneously. Of primary importance in systems neuroscience is the…

Neurons and Cognition · Quantitative Biology 2014-11-11 Yazan N. Billeh , Michael T. Schaub , Costas A. Anastassiou , Mauricio Barahona , Christof Koch

A key challenge in many modern data analysis tasks is that user data are heterogeneous. Different users may possess vastly different numbers of data points. More importantly, it cannot be assumed that all users sample from the same…

Cryptography and Security · Computer Science 2023-08-01 Rachel Cummings , Vitaly Feldman , Audra McMillan , Kunal Talwar

Recent advancements in single-cell RNA-sequencing (scRNA-seq) have enhanced our understanding of cell heterogeneity at a high resolution. With the ability to sequence over 10,000 cells per hour, researchers can collect large scRNA-seq…

Methodology · Statistics 2024-01-30 Yifu Tang , Yi Zhang , Yue Wang , Jingyi Zhang , Xiaoxiao Sun

In this paper, we study a smoothness regularization method for a varying coefficient model based on sparse and irregularly sampled functional data which is contaminated with some measurement errors. We estimate the one-dimensional…

Methodology · Statistics 2017-11-28 Behdad Mostafaiy

Inherent risk scoring is an important function in anti-money laundering, used for determining the riskiness of an individual during onboarding $\textit{before}$ fraudulent transactions occur. It is, however, often fraught with two…

Machine Learning · Computer Science 2018-12-02 W. Ronny Huang , Miguel A. Perez