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We introduce stochastic models of chemotaxis generalizing the deterministic Keller-Segel model. These models include fluctuations which are important in systems with small particle numbers or close to a critical point. Following Dean's…

Statistical Mechanics · Physics 2009-09-01 Pierre-Henri Chavanis

A phase field approach is proposed to model the chemotaxis of Dictyostelium discoideum. In this framework, motion is controlled by active forces as determined by the Meinhardt model of chemical dynamics which is used to simulate directional…

Biological Physics · Physics 2023-03-01 Yunsong Zhang , Herbert Levine , Yanxiang Zhao

Chemotaxis, i.e. motion generated by chemical gradients, is a motility mode shared by many living species that has been developed by evolution to optimize certain biological processes such as foraging or immune response. In particular,…

Soft Condensed Matter · Physics 2023-05-24 Hugues Meyer , Heiko Rieger

The primary emphasis of this work on kinetics is to illustrate the a posteriori approach to applications, where focus on data leads to novel outcomes, rather than the a priori tendencies of applied analysis which imposes constructs on the…

General Physics · Physics 2011-01-27 Christopher G. Jesudason

We study a biologically motivated model of overdamped, autochemotactic Brownian agents with concentration-dependent chemotactic sensitivity. The agents in our model move stochastically and produce a chemical ligand at their current…

Statistical Mechanics · Physics 2015-06-17 Marcel Meyer , Lutz Schimansky-Geier , Pawel Romanczuk

Enzyme-based systems have been shown to undergo directional motion in response to their substrate gradient. Here, we formulate a kinetic model to analyze the directional movement of an ensemble of protein molecules in response to a gradient…

Biological Physics · Physics 2021-03-26 Niladri Sekhar Mandal , Ayusman Sen

Cells rely on the ability to sense and respond to small spatial differences in chemoattractant concentrations for survival. There is growing evidence that this is accomplished by setting the signaling system near the threshold for…

Cell Behavior · Quantitative Biology 2022-05-19 Debojyoti Biswas , Parijat Banerjee , Pablo A. Iglesias

Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and…

Cell Behavior · Quantitative Biology 2015-03-20 Jin Yang

We perform stability analysis of a kinetic bacterial chemotaxis model of bacterial self-organization, assuming that bacteria respond sharply to chemical signals. The resulting discontinuous tumbling kernel represents the key challenge for…

Analysis of PDEs · Mathematics 2024-06-27 Vincent Calvez , Gianluca Favre , Franca Hoffmann

Motivated by the observation of non-exponential run-time distributions of bacterial swimmers, we propose a minimal phenomenological model for taxis of active particles whose motion is controlled by an internal clock. The ticking of the…

Biological Physics · Physics 2020-07-23 Luis Gómez Nava , Robert Großmann , Marius Hintsche , Carsten Beta , Fernando Peruani

A chemotaxis-diffusion-convection coupling system for describing a form of buoyant convection in which the fluid develops convection cells and plume patterns will be investigated numerically in this study. Based on the two-dimensional…

Fluid Dynamics · Physics 2015-02-19 Yannick Deleuze , Chen-Yu Chiang , Marc Thiriet , Tony W. H. Sheu

As motivated by studies of cellular motility driven by spatiotemporal chemotactic gradients in microdevices, we develop a framework for constructing approximate analytical solutions for the location, speed and cellular densities for cell…

Analysis of PDEs · Mathematics 2022-11-09 Jacobo Ayensa-Jiménez , Mohamed H. Doweidar , Manuel Doblaré , Eamonn A. Gaffney

We consider a second order PDEs system of Parabolic-Elliptic type with chemotactic terms. The system describes the evolution of a biological species "$u$" moving towards a higher concentration of a chemical stimuli "$v$" in a bounded and…

Analysis of PDEs · Mathematics 2021-11-08 M. Negreanu , J. Ignacio Tello

Enzymes show two distinct transport behaviors in the presence of their substrates in solution. First, their diffusivity enhances with increasing substrate concentration. In addition, enzymes perform directional motion toward regions with…

Biological Physics · Physics 2018-11-06 Farzad Mohajerani , Xi Zhao , Ambika Somasundar , Darrell Velegol , Ayusman Sen

Reaction rate equations are ordinary differential equations that are frequently used to describe deterministic chemical kinetics at the macroscopic scale. At the microscopic scale, the chemical kinetics is stochastic and can be captured by…

Soft Condensed Matter · Physics 2021-05-12 Ariana Torres-Knoop , Ivan Kryven

Active matter systems comprise self-propelled particles that move on a substrate while leaving chemical trails that influence other particles through chemotaxis (e.g., slime-depositing bacteria). Orientational chemotaxis manifests as a…

Soft Condensed Matter · Physics 2025-12-11 Aymeric Lutier , Frédéric van Wijland , Jean-Baptiste Fournier

In many sensory systems, transmembrane receptors are spatially organized in large clusters. Such arrangement may facilitate signal amplification and the integration of multiple stimuli. However, this organization likely also affects the…

Molecular Networks · Quantitative Biology 2014-03-05 William Pontius , Michael W. Sneddon , Thierry Emonet

Many eukaryotic cells are able to sense chemical gradients by directly measuring spatial concentration differences. The precision of such gradient sensing is limited by fluctuations in the binding of diffusing particles to specific…

Cell Behavior · Quantitative Biology 2010-06-04 Bo Hu , Wen Chen , Wouter-Jan Rappel , Herbert Levine

Turing patterns play a fundamental role in morphogenesis and population dynamics, encoding key information about the underlying biological mechanisms. Yet, traditional inverse problems have largely relied on non-biological data such as…

Analysis of PDEs · Mathematics 2025-09-10 Yuhan Li , Hongyu Liu , Catharine W. K. Lo

This work concerns with a class of chemotaxis models in which external sources, comprising nonlocal and gradient-dependent damping reactions, influence the motion of a cell density attracted by a chemical signal. The mechanism of the two…

Analysis of PDEs · Mathematics 2024-06-17 Rafael Díaz Fuentes , Silvia Frassu , Giuseppe Viglialoro
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