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Discrete-time regulatory networks are dynamical systems on directed graphs, with a structure inspired on natural systems of interacting units. There is a natural notion of determination amongst vertices, which we use to classify the nodes…

Adaptation and Self-Organizing Systems · Physics 2009-11-13 Beatriz Luna , Edgardo Ugalde

We study the dynamical properties of small regulatory networks treated as non autonomous dynamical systems called modules when working inside larger networks or, equivalently when subject to external signal inputs. Particular emphasis is…

Molecular Networks · Quantitative Biology 2009-07-07 Ricardo Lima , Arnaud Meyroneinc , Edgardo Ugalde

Genetic regulatory networks are usually modeled by systems of coupled differential equations and by finite state models, better known as logical networks, are also used. In this paper we consider a class of models of regulatory networks…

Dynamical Systems · Mathematics 2015-06-26 Ricardo Lima , Edgardo Ugalde

A biological regulatory network can be modeled as a discrete function that contains all available information on network component interactions. From this function we can derive a graph representation of the network structure as well as of…

Discrete Mathematics · Computer Science 2009-10-09 Heike Siebert

We introduce simple models of genetic regulatory networks and we proceed to the mathematical analysis of their dynamics. The models are discrete time dynamical systems generated by piecewise affine contracting mappings whose variables…

Dynamical Systems · Mathematics 2007-05-23 Ricardo Coutinho , Bastien Fernandez , Ricardo Lima , Arnaud Meyroneinc

This paper investigates questions related to the modularity in discrete models of biological interaction networks. We develop a theoretical framework based on the analysis of their asymptotic dynamics. More precisely, we exhibit formal…

Discrete Mathematics · Computer Science 2012-01-16 Franck Delaplace , Hanna Klaudel , Tarek Melliti , Sylvain Sené

We investigate the asymptotic dynamics of quantum networks under repeated applications of random unitary operations. It is shown that in the asymptotic limit of large numbers of iterations this dynamics is generally governed by a typically…

Quantum Physics · Physics 2009-04-02 J. Novotny , G. Alber , I. Jex

Spatio-temporal network dynamics is an emergent property of many complex systems which remains poorly understood. We suggest a new approach to its study based on the analysis of dynamical motifs -- small subnetworks with periodic and…

Disordered Systems and Neural Networks · Physics 2007-05-23 Valentin P. Zhigulin

We study discrete dynamical systems through the topological concepts of limit set, which consists of all points that can be reached arbitrarily late, and asymptotic set, which consists of all adhering values of orbits. In particular, we…

Dynamical Systems · Mathematics 2011-10-20 Guillon Pierre , Richard Gaétan

Random boolean networks are a model of genetic regulatory networks that has proven able to describe experimental data in biology. They not only reproduce important phenomena in cell dynamics, but they are also extremely interesting from a…

Dynamical Systems · Mathematics 2015-02-26 Marco Villani , Davide Campioli , Chiara Damiani , Andrea Roli , Alessandro Filisetti , Roberto Serra

Modeling gene regulatory networks (GRNs) is an important topic in systems biology. Although there has been much work focusing on various specific systems, the generic behavior of GRNs with continuous variables is still elusive. In…

Molecular Networks · Quantitative Biology 2014-04-23 Zhiyuan Li , Simone Bianco , Zhaoyang Zhang , Chao Tang

We compare asynchronous vs. synchronous update of discrete dynamical networks and find that a simple time delay in the nodes may induce a reproducible deterministic dynamics even in the case of asynchronous update in random order. In…

Molecular Networks · Quantitative Biology 2007-05-23 Konstantin Klemm , Stefan Bornholdt

Random Boolean networks (RBNs) have been a popular model of genetic regulatory networks for more than four decades. However, most RBN studies have been made with random topologies, while real regulatory networks have been found to be…

Cellular Automata and Lattice Gases · Physics 2015-03-17 Rodrigo Poblanno-Balp , Carlos Gershenson

Networks of degrade-and-fire oscillators are elementary models of populations of synthetic gene circuits with negative feedback, which show elaborate phenomenology while being amenable to mathematical analysis. In addition to thorough…

Adaptation and Self-Organizing Systems · Physics 2018-12-26 Bastien Fernandez

We analyze networked heterogeneous nonlinear systems, with diffusive coupling and interconnected over a generic static directed graph. Due to the network's hetereogeneity, complete synchronization is impossible, in general, but an emergent…

Optimization and Control · Mathematics 2022-06-01 Mohamed Maghenem , Elena Panteley , Antonio Loria

Time-discrete dynamical systems on a finite state space have been used with great success to model natural and engineered systems such as biological networks, social networks, and engineered control systems. They have the advantage of being…

Combinatorics · Mathematics 2015-03-17 Alan Veliz-Cuba , Reinhard Laubenbacher

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

This is the second paper of a series of two about the structural properties that influence the asymptotic dynamics of Random Boolean Networks. Here we study the functionally independent clusters in which the relevant elements, introduced…

Disordered Systems and Neural Networks · Physics 2009-10-30 U. Bastolla , G. Parisi

A basic model of a dynamical distribution network is considered, modeled as a directed graph with storage variables corresponding to every vertex and flow inputs corresponding to every edge, subject to unknown but constant inflows and…

Optimization and Control · Mathematics 2014-03-24 Jieqiang Wei , Arjan van der Schaft

Nonautonomous driving of an oscillator has been shown to enlarge the Arnold tongue in parameter space, but little is known about the analogous effect for a network of oscillators. To test the hypothesis that deterministic nonautonomous…

Adaptation and Self-Organizing Systems · Physics 2019-01-16 Maxime Lucas , Duccio Fanelli , Aneta Stefanovska
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