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Motivation: Gene set testing is typically performed in a supervised context to quantify the association between groups of genes and a clinical phenotype. In many cases, however, a gene set-based interpretation of genomic data is desired in…

Quantitative Methods · Quantitative Biology 2015-03-17 H. Robert Frost , Zhigang Li , Jason H. Moore

Data mining and machine learning techniques such as classification and regression trees (CART) represent a promising alternative to conventional logistic regression for propensity score estimation. Whereas incomplete data preclude the…

Machine Learning · Statistics 2018-07-26 Bas B. L. Penning de Vries , Maarten van Smeden , Rolf H. H. Groenwold

Epistemic uncertainty arises in lack of complete knowledge about the state of a system. There are multiple mathematical frameworks for measuring such uncertainty quantitatively, often referred to as imprecise probability theories. Inspired…

Category Theory · Mathematics 2026-03-05 Torgeir Aambø

Accurate diagnostic tests are essential for effective screening and treatment. However, individual biomarkers often fail to provide sufficient diagnostic accuracy, as they typically capture only one aspect of the complex disease process.…

Methodology · Statistics 2025-07-08 Ainesh Sewak , Sandra Siegfried , Torsten Hothorn

ProBoost, a new boosting algorithm for probabilistic classifiers, is proposed in this work. This algorithm uses the epistemic uncertainty of each training sample to determine the most challenging/uncertain ones; the relevance of these…

This paper delivers improved theoretical guarantees for the convex programming approach in low-rank matrix estimation, in the presence of (1) random noise, (2) gross sparse outliers, and (3) missing data. This problem, often dubbed as…

Machine Learning · Statistics 2022-09-13 Yuxin Chen , Jianqing Fan , Cong Ma , Yuling Yan

Reinforcement learning for open-ended text generation is constrained by the lack of verifiable rewards, necessitating reliance on judge models that require either annotated data or powerful closed-source models. Inspired by recent work on…

Computation and Language · Computer Science 2026-04-14 Xinda Wang , Zhengxu Hou , Yangshijie Zhang , Bingren Yan , Jialin Liu , Chenzhuo Zhao , Zhibo Yang , Bin-Bin Yang , Feng Xiao

With the developments in machine learning, there has been a surge in interest and results focused on algorithms utilizing predictions, not least in online algorithms where most new results incorporate the prediction aspect for concrete…

Data Structures and Algorithms · Computer Science 2026-02-02 Magnus Berg , Joan Boyar , Lene M. Favrholdt , Kim S. Larsen

Prediction rule ensembles (PREs) are a relatively new statistical learning method, which aim to strike a balance between predictive accuracy and interpretability. Starting from a decision tree ensemble, like a boosted tree ensemble or a…

Applications · Statistics 2023-10-02 Marjolein Fokkema , Carolin Strobl

Structured data in the form of tabular datasets contain features that are distinct and discrete, with varying individual and relative importances to the target. Combinations of one or more features may be more predictive and meaningful than…

Real-world indicators play an important role in many natural language processing (NLP) applications, such as life-event for mental health analysis and risky behaviour for online safety, yet labelling such information in training datasets is…

Information extracted from electrohysterography recordings could potentially prove to be an interesting additional source of information to estimate the risk on preterm birth. Recently, a large number of studies have reported near-perfect…

Component-Based Development (CBD) is a popular approach to mitigating the costs of creating software systems. However, it is not clear to what extent the core component selection and adaptation activities of CBD can be implemented to…

Software Engineering · Computer Science 2022-05-11 Todd Wareham , Marieke Sweers

Text classification is the task of automatically assigning text documents correct labels from a predefined set of categories. In real-life (text) classification tasks, observations and misclassification costs are often unevenly distributed…

Machine Learning · Computer Science 2025-09-03 Aleksi Avela , Pauliina Ilmonen

Polynomial chaos expansions (PCE) are widely used in the framework of uncertainty quantification. However, when dealing with high dimensional complex problems, challenging issues need to be faced. For instance, high-order polynomials may be…

Methodology · Statistics 2015-06-02 Chu V. Mai , Bruno Sudret

Despite Retrieval-Augmented Generation improving code completion, traditional retrieval methods struggle with information redundancy and a lack of diversity within limited context windows. To solve this, we propose a resource-optimized…

Software Engineering · Computer Science 2025-10-14 Xiaohan Chen , Zhongying Pan , Quan Feng , Yu Tian , Shuqun Yang , Mengru Wang , Lina Gong , Yuxia Geng , Piji Li , Xiang Chen

This contribution examines optimization problems that involve stochastic dominance constraints. These problems have uncountably many constraints. We develop methods to solve the optimization problem by reducing the constraints to a finite…

Optimization and Control · Mathematics 2025-02-27 Rajmadan Lakshmanan , Alois Pichler , Miloš Kopa

Randomised field experiments, such as A/B testing, have long been the gold standard for evaluating the value that new software brings to customers. However, running randomised field experiments is not always desired, possible or even…

Software Engineering · Computer Science 2022-07-04 Yuchu Liu , David Issa Mattos , Jan Bosch , Helena Holmström Olsson , Jonn Lantz

Resource constrained job scheduling is a hard combinatorial optimisation problem that originates in the mining industry. Off-the-shelf solvers cannot solve this problem satisfactorily in reasonable timeframes, while other solution methods…

Neural and Evolutionary Computing · Computer Science 2024-07-23 Su Nguyen , Dhananjay Thiruvady , Yuan Sun , Mengjie Zhang

Identifying which taxa in our microbiota are associated with traits of interest is important for advancing science and health. However, the identification is challenging because the measured vector of taxa counts (by amplicon sequencing) is…

Genomics · Quantitative Biology 2020-03-31 Barak Brill , Amnon Amir , Ruth Heller
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