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It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical…

Molecular Networks · Quantitative Biology 2007-05-23 Reiko Tanaka , Tau-Mu Yi , John Doyle

We propose and study a model of weighted scale-free networks incorporating a stochastic scheme for weight assignments to the links, taking into account both the popularity and fitness of a node. As the network grows the weights of links are…

Statistical Mechanics · Physics 2009-11-10 Dafang Zheng , Steffen Trimper , Bo Zheng , P. M. Hui

The growth of a population divided among spatial sites, with migration between the sites, is sometimes modelled by a product of random matrices, with each diagonal elements representing the growth rate in a given time period, and…

Populations and Evolution · Quantitative Biology 2018-09-12 David Steinsaltz , Shripad Tuljapurkar

The Raise and Peel model is a recently proposed one-dimensional statistical model describing a fluctuating interface. The evolution of the model follows from the competition between adsorption and desorption processes. The model is…

Statistical Mechanics · Physics 2009-11-11 Matteo Beccaria , Massimo Campostrini , Alessandra Feo

The molecular evolution in a gene regulatory network is classically modeled by Markov jump processes. However, the direct simulation of such models is extremely time consuming. Indeed, even the simplest Markovian model, such as the…

Probability · Mathematics 2012-11-30 Aurélie Muller-Gueudin

Generating function equation has been derived for the probability distribution of the number of nodes with $k \ge 0$ outgoing lines in randomly evolving special trees. The stochastic properties of end-nodes (k=0) have been analyzed, and it…

Statistical Mechanics · Physics 2007-05-23 L. Pal

We investigate various aspects of the statistics of leaders in growing network models defined by stochastic attachment rules. The leader is the node with highest degree at a given time (or the node which reached that degree first if there…

Physics and Society · Physics 2010-02-05 C. Godreche , H. Grandclaude , J. M. Luck

The dynamics of stochastic reaction networks within cells are inevitably modulated by factors considered extrinsic to the network such as for instance the fluctuations in ribsome copy numbers for a gene regulatory network. While several…

Quantitative Methods · Quantitative Biology 2015-06-19 Christoph Zechner , Heinz Koeppl

We analyze protein-protein interaction networks for six different species under the framework of random matrix theory. Nearest neighbor spacing distribution of the eigenvalues of adjacency matrices of the largest connected part of these…

Molecular Networks · Quantitative Biology 2014-05-20 Ankit Agrawal , Camellia Sarkar , Sanjiv K. Dwivedi , Nitesh Dhasmana , Sarika Jalan

Protein interaction networks aim to summarize the complex interplay of proteins in an organism. Early studies suggested that the position of a protein in the network determines its evolutionary rate but there has been considerable…

Molecular Networks · Quantitative Biology 2007-05-23 Ino Agrafioti , Jonathan Swire , James Abbott , Derek Huntley , Sarah Butcher , Michael P. H. Stumpf

Many networks are complex dynamical systems, where both attributes of nodes and topology of the network (link structure) can change with time. We propose a model of co-evolving networks where both node at- tributes and network structure…

Social and Information Networks · Computer Science 2011-06-15 Yoon-Sik Cho , Greg Ver Steeg , Aram Galstyan

Stochasticity plays important roles in molecular networks when molecular concentrations are in the range of $0.1 \mu$M to $10 n$M (about 100 to 10 copies in a cell). The chemical master equation provides a fundamental framework for studying…

Molecular Networks · Quantitative Biology 2013-03-14 Youfang Cao , Jie Liang

Networks are widely used to model the interaction between individual dynamical systems. In many instances, the total number of units as well as the interaction coupling are not fixed in time, but rather constantly evolve. In terms of…

Adaptation and Self-Organizing Systems · Physics 2023-09-19 Melvyn Tyloo

Biological neural networks are notoriously hard to model due to their stochastic behavior and high dimensionality. We tackle this problem by constructing a dynamical model of both the expectations and covariances of the fractions of active…

Neurons and Cognition · Quantitative Biology 2025-02-25 Vincent Painchaud , Patrick Desrosiers , Nicolas Doyon

Graph-based machine learning methods are useful tools in the identification and prediction of variation in genetic data. In particular, the comprehension of phenotypic effects at the cellular level is an accelerating research area in…

Quantitative Methods · Quantitative Biology 2024-12-06 Nandini Gadhia , Michalis Smyrnakis , Po-Yu Liu , Damer Blake , Melanie Hay , Anh Nguyen , Dominic Richards , Dong Xia , Ritesh Krishna

Ever since the Barab\'{a}si-Albert (BA) scale-free network has been proposed, network modeling has been studied intensively in light of the network growth and the preferential attachment (PA). However, numerous real systems are featured…

Social and Information Networks · Computer Science 2025-11-25 Yuhan Li , Minyu Feng , Jürgen Kurths

We present a framework to calculate the cascade size evolution for a large class of cascade models on random network ensembles in the limit of infinite network size. Our method is exact and applies to network ensembles with almost arbitrary…

Physics and Society · Physics 2018-04-25 Rebekka Burkholz , Frank Schweitzer

The stochastic growth-fragmentation model describes the temporal evolution of a structured cell population through a discrete-time and continuous-state Markov chain. The simulations of this stochastic process and its invariant measure are…

Numerical Analysis · Mathematics 2025-05-20 Dawei Wu , Zhennan Zhou

Preferential attachment --- by which new nodes attach to existing nodes with probability proportional to the existing nodes' degree --- has become the standard growth model for scale-free networks, where the asymptotic probability of a node…

Adaptation and Self-Organizing Systems · Physics 2014-11-12 Michael Small , Yingying Li , Thomas Stemler , Kevin Judd

In this work we study a simple evolutionary model of bipartite networks which its evolution is based on the duplication of nodes. Using analytical results along with numerical simulation of the model, we show that the above evolutionary…

Disordered Systems and Neural Networks · Physics 2009-11-10 A. Ramezanpour