Related papers: Exploring nervous system transcriptomes during emb…
Probing the developing neural circuitry in Caenorhabditis elegans has enhanced our understanding of nervous systems. The C. elegans connectome, like those of other species, is characterized by a rich club of densely connected neurons…
The nematode Caenorhabditis elegans (C. elegans) is used as a model organism to better understand developmental biology and neurobiology. C. elegans features an invariant cell lineage, which has been catalogued and observed using…
We propose an algebraic geometric framework to study the expressivity of linear activation neural networks. A particular quantity of neural networks that has been actively studied is the number of linear regions, which gives a…
Single-cell electrophysiological recordings provide a powerful window into neuronal functional diversity and offer an interpretable route for linking intrinsic physiology to transcriptomic identity. Here, we replicate and extend the…
The metazoan body plan is established during early embryogenesis via collective cell rearrangements and evolutionarily conserved gene networks, as part of a process commonly referred to as gastrulation. While substantial progress has been…
Morphology based analysis of cell types has been an area of great interest to the neuroscience community for several decades. Recently, high resolution electron microscopy (EM) datasets of the mouse brain have opened up opportunities for…
Larval zebrafish exhibit a variety of complex undulatory swimming patterns. This repertoire is controlled by the 300 neurons projecting from brain into spinal cord. Understanding how descending control signals shape the output of spinal…
Deep learning methods have become very successful at solving many complex tasks such as image classification and segmentation, speech recognition and machine translation. Nevertheless, manually designing a neural network for a specific…
In this work, we present the analysis of 33,054 M-dwarf stars located within 100 parsecs in the Transiting Exoplanet Survey Satellite (TESS) Full Frame Images (FFIs) of the observed sectors 1 to 5. We present a new pipeline called NEMESIS…
Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…
Reconstructing neuronal circuits at the level of synapses is a central problem in neuroscience and becoming a focus of the emerging field of connectomics. To date, electron microscopy (EM) is the most proven technique for identifying and…
The Transiting Exoplanet Survey Satellite (TESS) mission measured light from stars in ~85% of the sky throughout its two-year primary mission, resulting in millions of TESS 30-minute cadence light curves to analyze in the search for…
Background: Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the mouse transcriptome. Results: We compiled…
Comparative genetic studies of non-model organisms are transforming rapidly due to major advances in sequencing technology. A limiting factor in these studies has been the identification and screening of orthologous loci across an…
In Xenopus early embryos, replication origins neither require specific DNA sequences nor is there an efficient S/M checkpoint, even though the whole genome (3 billion bases) is completely duplicated within 10-20 minutes. This leads to…
Transcription is the first step of gene expression, in which a particular segment of DNA is copied to RNA by the enzyme RNA polymerase (RNAP). Despite many details of the complex interactions between DNA and RNA synthesis disclosed…
Sleep stage classification is a widely discussed topic, due to its importance in the diagnosis of sleep disorders, e.g. insomnia. Analysis of the brain activity during sleep is necessary to gain further insight into the processing that…
The CM Draconis system is a well-studied, double-lined spectroscopic binary that is totally eclipsing and exhibits strong magnetic activity. Nearly one million photometric measurements have been collected across multiple wavelengths over…
This study introduces an approach to detecting exocomet transits in the dataset of the Transiting Exoplanet Survey Satellite (TESS), specifically within its Sector 1. Given the limited number of exocomet transits detected in the observed…
Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new…