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In this paper, we consider the problem of designing optimal pooling matrix for group testing (for example, for COVID-19 virus testing) with the constraint that no more than $r>0$ samples can be pooled together, which we call "dilution…

Quantitative Methods · Quantitative Biology 2020-08-06 Jirong Yi , Myung Cho , Xiaodong Wu , Raghu Mudumbai , Weiyu Xu

Specimens are collected from $N$ different sources. Each specimen has probability $p$ of being contaminated (e.g., in the case of an infectious disease, $p$ is the prevalence rate), independently of the other specimens. In many cases group…

Probability · Mathematics 2024-01-31 Vassilis G. Papanicolaou

Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less…

The Neyman-Pearson (NP) binary classification paradigm constrains the more severe type of error (e.g., the type I error) under a preferred level while minimizing the other (e.g., the type II error). This paradigm is suitable for…

Methodology · Statistics 2022-06-07 Jingming Wang , Lucy Xia , Zhigang Bao , Xin Tong

We give a hybrid two stage design which can be useful to estimate the reliability of a parallel-series and/or by duality a series-parallel system, when the component reliabilities are unknown as well as the total numbers of units allowed to…

Applications · Statistics 2012-12-27 Zohra Benkamra , Mekki Terbeche , Mounir Tlemcani

We are now witnessing a rapid growth of a new part of group theory which has become known as "statistical group theory". A typical result in this area would say something like ``a random element (or a tuple of elements) of a group G has a…

Group Theory · Mathematics 2007-05-23 Alexandre V. Borovik , Alexei G. Myasnikov , Vladimir Shpilrain

Choosing an optimal strategy for hierarchical group testing is an important problem for practitioners who are interested in disease screening with limited resources. For example, when screening for infectious diseases in large populations,…

Methodology · Statistics 2020-02-27 Yaakov Malinovsky , Gregory Haber , Paul S. Albert

Machine learning applications frequently come with multiple diverse objectives and constraints that can change over time. Accordingly, trained models can be tuned with sets of hyper-parameters that affect their predictive behavior (e.g.,…

Machine Learning · Computer Science 2022-10-17 Bracha Laufer-Goldshtein , Adam Fisch , Regina Barzilay , Tommi Jaakkola

We revisit the outlier hypothesis testing framework of Li \emph{et al.} (TIT 2014) and derive fundamental limits for the optimal test under the generalized Neyman-Pearson criterion. In outlier hypothesis testing, one is given multiple…

Information Theory · Computer Science 2022-02-15 Lin Zhou , Yun Wei , Alfred Hero

In the number partitioning problem (NPP) one aims to partition a given set of $N$ real numbers into two subsets with approximately equal sum. The NPP is a well-studied optimization problem and is famous for possessing a…

Statistics Theory · Mathematics 2025-05-28 Rushil Mallarapu , Mark Sellke

When many (m) null hypotheses are tested with a single dataset, the control of the number of false rejections is often the principal consideration. Two popular controlling rates are the probability of making at least one false discovery…

Methodology · Statistics 2013-07-11 Djalel Eddine Meskaldji , Jean-Philippe Thiran , Stephan Morgenthaler

Many testing problems are readily amenable to randomised tests such as those employing data splitting. However despite their usefulness in principle, randomised tests have obvious drawbacks. Firstly, two analyses of the same dataset may…

Methodology · Statistics 2024-09-05 F. Richard Guo , Rajen D. Shah

We first review existing sequential methods for estimating a binomial proportion. Afterward, we propose a new family of group sequential sampling schemes for estimating a binomial proportion with prescribed margin of error and confidence…

Statistics Theory · Mathematics 2013-11-05 Zhengjia Chen , Xinjia Chen

In this paper we investigate the asymptotic distribution of likelihood ratio tests in models with several groups, when the number of groups converges with the dimension and sample size to infinity. We derive central limit theorems for the…

Statistics Theory · Mathematics 2019-07-17 Holger Dette , Nina Dörnemann

Group testing is a long studied problem in combinatorics: A small set of $r$ ill people should be identified out of the whole ($n$ people) by using only queries (tests) of the form "Does set X contain an ill human?". In this paper we…

Data Structures and Algorithms · Computer Science 2008-04-29 Ely Porat , Amir Rothschild

Hypothesis testing in contingency tables is usually based on asymptotic results, thereby restricting its proper use to large samples. To study these tests in small samples, we consider the likelihood ratio test and define an accurate index,…

Methodology · Statistics 2018-10-04 Natalia L. Oliveira , Carlos A. de B. Pereira , Marcio A. Diniz , Adriano Polpo

We characterize the asymptotic performance of nonparametric one- and two-sample testing. The exponential decay rate or error exponent of the type-II error probability is used as the asymptotic performance metric, and an optimal test…

Information Theory · Computer Science 2021-02-08 Shengyu Zhu , Biao Chen , Zhitang Chen , Pengfei Yang

We consider an efficiently decodable non-adaptive group testing (NAGT) problem that meets theoretical bounds. The problem is to find a few specific items (at most $d$) satisfying certain characteristics in a colossal number of $N$ items as…

Information Theory · Computer Science 2017-11-20 Thach V. Bui , Minoru Kuribayashi , Isao Echizen

Identification of up to $d$ defective items and up to $h$ inhibitors in a set of $n$ items is the main task of non-adaptive group testing with inhibitors. To efficiently reduce the cost of this Herculean task, a subset of the $n$ items is…

Information Theory · Computer Science 2019-01-10 Thach V. Bui , Minoru Kuribayashi , Tetsuya Kojima , Isao Echizen

Motivated by real-world machine learning applications, we analyze approximations to the non-asymptotic fundamental limits of statistical classification. In the binary version of this problem, given two training sequences generated according…

Information Theory · Computer Science 2018-12-07 Lin Zhou , Vincent Y. F. Tan , Mehul Motani
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