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Related papers: Reconstructing pedigrees: a stochastic perspective

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A pedigree is a directed graph in which each vertex (except the founder vertices) has two parents. The main result in this paper is a construction of an infinite family of counter examples to a reconstruction problem on pedigrees, thus…

Combinatorics · Mathematics 2010-09-21 Bhalchandra D. Thatte

Pedigrees are directed acyclic graphs that represent ancestral relationships between individuals in a population. Based on a schematic recombination process, we describe two simple Markov models for sequences evolving on pedigrees - Model R…

Populations and Evolution · Quantitative Biology 2013-01-18 Bhalchandra D. Thatte

We introduce a new algorithm called {\sc Rec-Gen} for reconstructing the genealogy or \textit{pedigree} of an extant population purely from its genetic data. We justify our approach by giving a mathematical proof of the effectiveness of…

Data Structures and Algorithms · Computer Science 2020-05-11 Younhun Kim , Elchanan Mossel , Govind Ramnarayan , Paxton Turner

In an extant population, how much information do extant individuals provide on the pedigree of their ancestors? Recent work by Kim, Mossel, Ramnarayan and Turner (2020) studied this question under a number of simplifying assumptions,…

Populations and Evolution · Quantitative Biology 2022-11-29 Elchanan Mossel , David Vulakh

Reconstruction of family trees, or pedigree reconstruction, for a group of individuals is a fundamental problem in genetics. The problem is known to be NP-hard even for datasets known to only contain siblings. Some recent methods have been…

Data Structures and Algorithms · Computer Science 2014-08-26 Dan He , Zhanyong Wang , Laxmi Parida , Eleazar Eskin

We analyse the statistical properties of genealogical trees in a neutral model of a closed population with sexual reproduction and non-overlapping generations. By reconstructing the genealogy of an individual from the population evolution,…

Condensed Matter · Physics 2009-10-31 Bernard Derrida , Susanna C. Manrubia , Damian H. Zanette

Genealogical networks, also known as family trees or population pedigrees, are commonly studied by genealogists wanting to know about their ancestry, but they also provide a valuable resource for disciplines such as digital demography,…

Social and Information Networks · Computer Science 2018-02-19 Eric Malmi , Aristides Gionis , Arno Solin

Pedigree graphs, or family trees, are typically constructed by an expensive process of examining genealogical records to determine which pairs of individuals are parent and child. New methods to automate this process take as input genetic…

Data Structures and Algorithms · Computer Science 2011-10-19 Bonnie Kirkpatrick , Yakir Reshef , Hilary Finucane , Haitao Jiang , Binhai Zhu , Richard M. Karp

In a population with haploid reproduction any individual has a single parent in the previous generation. If all genealogical distances among pairs of individuals (generations from the closest common ancestor) are known it is possible to…

Populations and Evolution · Quantitative Biology 2015-05-13 Luce Prignano , Maurizio Serva

Pedigrees, or family trees, are graphs of family relationships that are used to study inheritance. A fundamental problem in computational biology is to find, for a pedigree with $n$ individuals genotyped at every site, a set of…

Data Structures and Algorithms · Computer Science 2016-02-16 Bonnie Kirkpatrick

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

A probabilistic reconstruction of genealogies in a polyploid population (from 2x to 4x) is investigated, by considering genetic data analyzed as the probability of allele presence in a given genotype. Based on the likelihood of all possible…

Populations and Evolution · Quantitative Biology 2018-11-29 Frédéric Proïa , Fabien Panloup , Chiraz Trabelsi , Jérémy Clotault

Recent advances in high-throughput genomics technologies have resulted in the sequencing of large numbers of (near) complete genomes. These genome sequences are being mined for important functional elements, such as genes. They are also…

Genomics · Quantitative Biology 2007-05-23 Lior Pachter

Repetitions within a given genealogical tree provides some information about the degree of consanguineity of a population. They can be analyzed with techniques usually employed in statistical physics when dealing with fixed point…

Statistical Mechanics · Physics 2009-10-31 Paolo De Los Rios , Oscar Pla

A hierarchical structure describing the inter-relationships of species has long been a fundamental concept in systematic biology, from Linnean classification through to the more recent quest for a 'Tree of Life.' In this paper we use an…

Populations and Evolution · Quantitative Biology 2009-08-21 Andreas Dress , Vincent Moulton , Mike Steel , Taoyang Wu

Phylogenetic reconstruction aims at finding plausible hypotheses of the evolutionary history of genes or species based on genomic sequence information. The distinction of orthologous genes (genes that having a common ancestry and diverged…

Populations and Evolution · Quantitative Biology 2016-02-29 Marc Hellmuth , Nicolas Wieseke

Some methods aim to correct or test for relationships or to reconstruct the pedigree, or family tree. We show that these methods cannot resolve ties for correct relationships due to identifiability of the pedigree likelihood which is the…

Quantitative Methods · Quantitative Biology 2016-02-29 B. Kirkpatrick

Inference with population genetic data usually treats the population pedigree as a nuisance parameter, the unobserved product of a past history of random mating. However, the history of genetic relationships in a given population is a…

Populations and Evolution · Quantitative Biology 2019-04-02 Peter L. Ralph

Data obtained from ISSR amplification may readily be extracted but only allows us to know, for each gene, if a specific allele is present or not. From this partial information we provide a probabilistic method to reconstruct the pedigree…

Populations and Evolution · Quantitative Biology 2015-08-04 Loïc Chaumont , Valéry Malécot , Richard Pymar , Chaker Sbai

An evolutionary tree is a cascade of bifurcations starting from a single common root, generating a growing set of daughter species as time goes by. Species here is a general denomination for biological species, spoken languages or any other…

Quantitative Methods · Quantitative Biology 2013-08-26 Paulo Murilo Castro de Oliveira
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