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The signal from many single molecule experiments monitoring molecular processes, such as enzyme turnover via fluorescence and opening and closing of ion channel via the flux of ions, consists of a time series of stochastic on and off (or…

Quantitative Methods · Quantitative Biology 2007-05-23 Ophir Flomenbom , Robert J. Silbey

Deducing an underlying multi-substate on-off kinetic scheme (KS) from the statistical properties of a two-state trajectory is the aim from many experiments in biophysics and chemistry, such as, ion channel recordings, enzymatic activity and…

Quantitative Methods · Quantitative Biology 2011-04-11 Ophir Flomenbom

Trajectories of on-off events are the output of many single molecule experiments. Usually, one describes the underlying mechanism that generates the trajectory using a kinetic scheme, and by analyzing the trajectory aims at deducing this…

Subcellular Processes · Quantitative Biology 2010-08-16 Ophir Flomenbom , Joseph Klafter

We develop an general formalism of single enzyme kinetics in two dimension where substrates diffuse stochastically on a square lattice in presence of disorder. The dynamics of the model could be decoupled effectively to two stochastic…

Chemical Physics · Physics 2009-01-20 Mahashweta Basu , P. K. Mohanty

Paper is devoted to maintaining the simple objective: We want to provide Hamiltonian canonical form for autonomous dynamical system reducible to even-dimensional one. Along the road we construct new class of conserved quantities, called…

Mathematical Physics · Physics 2020-08-28 Artur Kobus

A time trajectory of an observable that fluctuates between two values (say, on and off), stemming from some unknown multi-substate kinetic scheme, is the output of many single molecule experiments. Here we show that when all successive…

Subcellular Processes · Quantitative Biology 2010-08-16 Ophir Flomenbom , Joseph Klafter , Attila Szabo

Phenomena in chemistry, biology and neuroscience are often modelled using ordinary differential equations (ODEs) in which the right-hand-side is comprised of terms which correspond to individual 'processes' or 'fluxes'. Frequently, these…

Dynamical Systems · Mathematics 2021-09-30 Samuel Jelbart , Nathan Pages , Vivien Kirk , James Sneyd , Martin Wechselberger

A variant of the classical optimal transportation problem is: among all joint measures with fixed marginals and which are dominated by a given density, find the optimal one. Existence and uniqueness of solutions to this variant were…

Optimization and Control · Mathematics 2018-01-23 Jonathan Korman , Robert J. McCann

Trajectories of a signal that fluctuates between two states which originate from single molecule activities have become ubiquitous. Common examples are trajectories of ionic flux through individual membrane-channels, and of photon counts…

Quantitative Methods · Quantitative Biology 2007-05-23 Ophir Flomenbom , J. Klafter

The exploration of complex physical or technological processes usually requires exploiting available information from different sources: (i) physical laws often represented as a family of parameter dependent partial differential equations…

Numerical Analysis · Mathematics 2020-02-04 Albert Cohen , Wolfgang Dahmen , Ron DeVore

Chemical kinetic models in terms of ordinary differential equations correspond to finite dimensional dissipative dynamical systems involving a multiple time scale structure. Most dimension reduction approaches aimed at a slow…

Dynamical Systems · Mathematics 2014-10-27 Dirk Lebiedz , Jonas Unger

The adoption of detailed mechanisms for chemical kinetics often poses two types of severe challenges: First, the number of degrees of freedom is large; and second, the dynamics is characterized by widely disparate time scales. As a result,…

Dynamical Systems · Mathematics 2025-10-01 Eliodoro Chiavazzo , C. William Gear , Carmeline J. Dsilva , Neta Rabin , Ioannis G. Kevrekidis

The limiting slow dynamics of slow-fast, piecewise-linear, continuous systems of ODEs occurs on critical manifolds that are piecewise-linear. At points of non-differentiability, such manifolds are not normally hyperbolic and so the…

Dynamical Systems · Mathematics 2018-01-16 David J. W. Simpson

Quantum trajectory theory, developed largely in the quantum optics community to describe open quantum systems subjected to continuous monitoring, has applications in many areas of quantum physics. In this paper I present a simple model,…

Quantum Physics · Physics 2009-11-07 Todd A. Brun

The characterization of quantum processes is a key tool in quantum information processing tasks for several reasons: on one hand, it allows to acknowledge errors in the implementations of quantum algorithms; on the other, it allows to…

Quantum Physics · Physics 2018-12-12 Ignacio Perito , Augusto Roncaglia , Ariel Bendersky

We exhibit an explicit, deterministic algorithm for finding a canonical form for a positive definite matrix under unimodular integral transformations. We use characteristic sets of short vectors and partition-backtracking graph software.…

Number Theory · Mathematics 2020-11-17 Mathieu Dutour Sikirić , Anna Haensch , John Voight , Wessel P. J. van Woerden

We consider multiple k-essence sources and obtain the conditions their kinetic functions must satisfy so that purely kinetic k-essences lead to models with phantom barrier crossing. After that, we show that polynomial kinetic functions…

Astrophysics · Physics 2009-11-11 Luis P. Chimento , Ruth Lazkoz

Optimization methods have been broadly applied to two classes of objects viz. (i) modeling and description of data and (ii) the determination of the stationary points of functions. Here, a theoretical basis is developed that optimizes an…

Optimization and Control · Mathematics 2013-07-10 Christopher G. Jesudason

Discrete canonical evolution is a key tool for understanding the dynamics in discrete models of spacetime, in particular those represented by a triangular Regge lattice. We consider a finite-dimensional system whose evolution is realized by…

General Relativity and Quantum Cosmology · Physics 2020-11-18 Jakub Káninský

Ensemble control, an emerging research field focusing on the study of large populations of dynamical systems, has demonstrated great potential in numerous scientific and practical applications. Striking examples include pulse design for…

Optimization and Control · Mathematics 2022-11-08 Wei Zhang , Jr-Shin Li
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