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In multicellular organisms, cells coordinate their activities through cell-cell communication (CCC), which is crucial for development, tissue homeostasis, and disease progression. Recent advances in single-cell and spatial omics…
Associative learning is one of the key mechanisms displayed by living organisms in order to adapt to their changing environments. It was early recognized to be a general trait of complex multicellular organisms but also found in "simpler"…
Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studies have cataloged many molecular and cellular actors involved in an immune response, the…
In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving…
Causal ordering of key events in the cell cycle is essential for proper functioning of an organism. Yet, it remains a mystery how a specific temporal program of events is maintained despite ineluctable stochasticity in the biochemical…
Predicting and understanding the changes in cognitive performance, especially after a longitudinal intervention, is a fundamental goal in neuroscience. Longitudinal brain stimulation-based interventions like transcranial direct current…
We propose a computational model of neuron, called firing cell (FC), properties of which cover such phenomena as attenuation of receptors for external stimuli, delay and decay of postsynaptic potentials, modification of internal weights due…
Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory…
This study demonstrates the capability of external signal recording into memory and the reproduction of memory trace of this pattern in EEG by direct AC electrical stimulation of rat cerebral cortex. Additionally, we examine shifts of the…
T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding how T cell receptors (TCRs) discriminate…
In the context of a Brain Computer Interface platform implemented for the arm rehabilitation of mildly impaired stroke patients, two methods of EEG signals processing are compared in terms of (i) their identification performance rate and…
Objective. In neuroscience, time-frequency analysis has been used to get insight into brain rhythms from brain recordings. In event-related protocols, one applies it to investigate how the brain responds to a stimulation repeated over many…
The down regulation of CD3 protein present on the surface of a T-cell triggers the process of activation. A rapid decrease of CD3 from the surface is required to reach the threshold that is necessary for the continuation of the activation…
Cells are constantly exposed to fluctuating environmental conditions. External signals are sensed, processed and integrated by cellular signal transduction networks, which translate input signals into specific cellular responses by means of…
Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…
Particle-in-cell codes are the most widely used simulation tools for kinetic studies of ultra-intense laser-plasma interactions. Using the motion of a single electron in a plane electromagnetic wave as a benchmark problem, we show…
Bacteria sense a diverse range of environmental analytes with high sensitivity and temporal resolution. Engineering and synthetic biology approaches enabled harnessing this capability through development of whole-cell biosensors that…
Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we present a biophysically realistic model of Treg mediated…
Electroencephalogram-based brain-computer interface (BCI) has potential applications in various fields, but their development is hindered by limited data and significant cross-individual variability. Inspired by the principles of learning…
We present high-resolution path-integral calculations of a previously developed model of short-term memory in neocortex. These calculations, made possible with supercomputer resources, supplant similar calculations made in L. Ingber, Phys.…