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We consider a prototypical model in which a nonlinear field (continuum or discrete) evolves on a flexible substrate which feeds back to the evolution of the main field. We identify the underlying physics and potential applications of such a…

Pattern Formation and Solitons · Physics 2009-11-07 P. G. Kevrekidis , B. A. Malomed , A. R. Bishop

This paper aims at a comprehensive understanding on the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers…

Soft Condensed Matter · Physics 2009-10-31 Haijun Zhou , Yang Zhang , Zhong-can Ou-Yang

We study the size fluctuations of a local denaturation zone in a DNA molecule in the presence of proteins that selectively bind to single-stranded DNA, based on a (2+1)-dimensional master equation. By tuning the physical parameters we can…

Biomolecules · Quantitative Biology 2007-05-23 Tobias Ambjornsson , Ralf Metzler

At present, there have been suggested two types of physical mechanism that may facilitate preferential pairing between DNA molecules, with identical or similar base pair texts, without separation of base pairs. One solely relies on base…

Biological Physics · Physics 2017-11-06 Dominic. J. , Lee

The denaturation transition of circular DNA is studied within a Poland-Scheraga type approach, generalized to account for the fact that the total linking number (LK), which measures the number of windings of one strand around the other, is…

Statistical Mechanics · Physics 2015-06-05 Amir Bar , Alkan Kabakçıoğlu , David Mukamel

We study nonlinear dynamics of a periodic inhomogeneous DNA double helical chain under dynamic plane-base rotator model by considering angular rotation of bases in a plane normal to the helical axis. The dynamics is governed by a perturbed…

Pattern Formation and Solitons · Physics 2008-07-16 M. Daniel , V. Vasumathi

Complementary DNA strands in solution reliably hybridize to form stable duplexes. We study the kinetics of the hybridization process and the mechanisms by which two initially isolated strands come together to form a stable double helix. We…

Biological Physics · Physics 2019-03-27 Raymond Jin , Lutz Maibaum

In this Letter, we investigate the link between thermal denaturation and mechanical unzipping for two models of DNA, namely the Dauxois-Peyrard-Bishop model and a variant thereof we proposed recently. We show that the critical line that…

Biological Physics · Physics 2010-01-05 Sahin Buyukdagli , Marc Joyeux

We study the effect of the composition of the genetic sequence on the melting temperature of double stranded DNA, using some simple analytically solvable models proposed in the framework of the wetting problem. We review previous work on…

Statistical Mechanics · Physics 2007-05-23 Saul Ares , Angel Sanchez

We present a thermodynamically robust coarse-grained model to simulate folding of RNA in monovalent salt solutions. The model includes stacking, hydrogen bond and electrostatic interactions as fundamental components in describing the…

Biomolecules · Quantitative Biology 2013-04-16 Natalia A. Denesyuk , D. Thirumalai

We had combined the Neukirch-Marko model that describes the extension, torque and supercoiling in single, stretched and twisted DNA of infinite contour length, with a form of the free energy suggested by Sinha and Samuels to describe short…

Soft Condensed Matter · Physics 2017-11-22 Pui-Man Lam , Yi Zhen

Extreme deformations of the DNA double helix attracted a lot of attention during the past decades. Particularly, the determination of the persistence length of DNA with extreme local disruptions, or kinks, has become a crucial problem in…

Biological Physics · Physics 2018-10-30 Kyryło A. Simonov

As a key molecule of Life, Deoxyribonucleic acid (DNA) is the focus of numbers of investigations with the help of biological, chemical and physical techniques. From a physical point of view, both experimental and theoretical works have…

Soft Condensed Matter · Physics 2016-05-26 Manoel Manghi , Nicolas Destainville

The closure of long equilibrated denaturation bubbles in DNA is studied using Brownian dynamics simulations. A minimal mesoscopic model is used where the double-helix is made of two interacting bead-spring freely rotating strands, with a…

Soft Condensed Matter · Physics 2015-06-12 Anil Kumar Dasanna , Nicolas Destainville , John Palmeri , Manoel Manghi

DNA is structurally and mechanically altered by the binding of intercalator molecules. Intercalation strongly affects the force-extension behavior of DNA, in particular the overstretching transition. We present a statistical model that…

A comparison is made between conventional Michaelis-Menten kinetics and two models that take into account the duration of the conformational changes that take place at the molecular level during the catalytic cycle of a monomer. The models…

Molecular Networks · Quantitative Biology 2007-12-05 José M. Albornoz , Antonio Parravano

Spatially extended stationary and traveling states in the strongly nonlinear regime of convection in layers of binary fluid mixtures heated from below are described by a few-mode-model. It is derived from the proper hydrodynamic balance…

patt-sol · Physics 2009-10-30 St. Hollinger , M. Luecke

The wormlike chain (WLC) model of DNA bending accurately reproduces single-molecule force-extension profiles of long (kilobase) chains. These bending statistics over large scales do not, however, establish a unique microscopic model for…

Statistical Mechanics · Physics 2013-01-17 David A. Sivak , Phillip L. Geissler

We model the electron clouds of nucleic acids in DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours resulting in a van der Waals type bonding. Crucial parameters in our model are…

Quantum Physics · Physics 2011-02-24 Elisabeth Rieper , Janet Anders , Vlatko Vedral

Collective response of DNA to THz electric fields is studied in a simple pair bond model. We confirm, with some caveats, a previous observation of destabilising DNA breather modes and explore the parameter-dependence of these modes. It is…

Biological Physics · Physics 2013-05-29 Eric S. Swanson