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This work addresses computing techniques for dose calculations in treatment planning with proton and ion beams, based on an efficient kernel-convolution method referred to as grid-dose spreading (GDS) and accurate heterogeneity-correction…

Medical Physics · Physics 2012-01-11 Nobuyuki Kanematsu

Medical imaging plays a pivotal role in diagnosis and treatment in clinical practice. Inspired by the significant progress in automatic image captioning, various deep learning (DL)-based methods have been proposed to generate radiology…

Computer Vision and Pattern Recognition · Computer Science 2022-02-04 Yixin Wang , Zihao Lin , Zhe Xu , Haoyu Dong , Jiang Tian , Jie Luo , Zhongchao Shi , Yang Zhang , Jianping Fan , Zhiqiang He

This work aims to study the generalizability of a pre-developed deep learning (DL) dose prediction model for volumetric modulated arc therapy (VMAT) for prostate cancer and to adapt the model to three different internal treatment planning…

Constructing probability densities for inference in high-dimensional spectral data is often intractable. In this work, we use normalizing flows on structured spectral latent spaces to estimate such densities, enabling downstream inference…

Machine Learning · Computer Science 2021-08-20 Katiana Kontolati , Natalie Klein , Nishant Panda , Diane Oyen

Multi-task neural network architectures provide a mechanism that jointly integrates information from distinct sources. It is ideal in the context of MR-only radiotherapy planning as it can jointly regress a synthetic CT (synCT) scan and…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Felix J. S. Bragman , Ryutaro Tanno , Zach Eaton-Rosen , Wenqi Li , David J. Hawkes , Sebastien Ourselin , Daniel C. Alexander , Jamie R. McClelland , M. Jorge Cardoso

Uncertainty visualizations often emphasize point estimates to support magnitude estimates or decisions through visual comparison. However, when design choices emphasize means, users may overlook uncertainty information and misinterpret…

Human-Computer Interaction · Computer Science 2020-09-15 Alex Kale , Matthew Kay , Jessica Hullman

Conjunction assessment requires knowledge of the uncertainty in the predicted orbit. Errors in the atmospheric density are a major source of error in the prediction of low Earth orbits. Therefore, accurate estimation of the density and…

Earth and Planetary Astrophysics · Physics 2020-04-24 David J. Gondelach , Richard Linares

This paper proposes new estimators for the propensity score that aim to maximize the covariate distribution balance among different treatment groups. Heuristically, our proposed procedure attempts to estimate a propensity score model by…

Econometrics · Economics 2020-04-07 Pedro H. C. Sant'Anna , Xiaojun Song , Qi Xu

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

Medical Physics · Physics 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

In this work, we develop a kinetic model of tumour growth taking into account the effects of clinical uncertainties characterising the tumours' progression. The action of therapeutic protocols trying to steer the tumours' volume towards a…

Radiation therapy is a critical component of cancer treatment. However, the delivery of radiation poses inherent challenges, particularly in minimizing radiation exposure to healthy organs surrounding the tumor site. One significant…

Optimization and Control · Mathematics 2024-01-22 Keshav Kumar K. , NVSL Narasimham

For a certain moment, the information volume represented in a probability space can be accurately measured by Shannon entropy. But in real life, the results of things usually change over time, and the prediction of the information volume…

Information Theory · Computer Science 2020-12-15 Qianli Zhou , Yong Deng

In quantum chaos, the spectral statistics generally follows the predictions of Random Matrix Theory (RMT). A notable exception is given by scar states, that enhance probability density around unstable periodic orbits of the classical…

Chaotic Dynamics · Physics 2022-07-19 Domenico Lippolis

Purpose: Deep-learning-based three-dimensional (3D) dose prediction is widely used in automated radiotherapy workflows. However, most existing models are trained with voxel-wise regression losses, which are poorly aligned with clinical plan…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Ruochen Gao , Marius Staring , Frank Dankers

This paper proposes a novel approach for uncertainty quantification in dense Conditional Random Fields (CRFs). The presented approach, called Perturb-and-MPM, enables efficient, approximate sampling from dense multi-label CRFs via random…

Computer Vision and Pattern Recognition · Computer Science 2017-03-03 Raphael Meier , Urspeter Knecht , Alain Jungo , Roland Wiest , Mauricio Reyes

Estimating and disentangling epistemic uncertainty, uncertainty that is reducible with more training data, and aleatoric uncertainty, uncertainty that is inherent to the task at hand, is critically important when applying machine learning…

Machine Learning · Computer Science 2024-11-08 Matthew A. Chan , Maria J. Molina , Christopher A. Metzler

As machine learning (ML) continue to be integrated into healthcare systems that affect clinical decision making, new strategies will need to be incorporated in order to effectively detect and evaluate subgroup disparities to ensure…

Machine Learning · Computer Science 2021-07-19 Charles Lu , Andreanne Lemay , Katharina Hoebel , Jayashree Kalpathy-Cramer

A particularly challenging problem in AI safety is providing guarantees on the behavior of high-dimensional autonomous systems. Verification approaches centered around reachability analysis fail to scale, and purely statistical approaches…

Artificial Intelligence · Computer Science 2025-03-11 Souradeep Dutta , Michele Caprio , Vivian Lin , Matthew Cleaveland , Kuk Jin Jang , Ivan Ruchkin , Oleg Sokolsky , Insup Lee

The purpose of this study is to measure the internal radiation dose using a human blood sample. In the literature, there is no process that allows the direct measurement of the internal radiation dose received by a person. The luminescence…

Medical Physics · Physics 2016-01-15 Ayse Güneş Tanır , Özge Güleç

In this paper, we present an uncertainty-aware INVASE to quantify predictive confidence of healthcare problem. By introducing learnable Gaussian distributions, we lever-age their variances to measure the degree of uncertainty. Based on the…

Machine Learning · Computer Science 2021-05-07 Jia-Xing Zhong , Hongbo Zhang
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