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The aggregation or clustering of proteins and other macromolecules plays an important role in the formation of large-scale molecular assemblies within cell membranes. Examples include lipid rafts and postsynaptic domains (PSDs). PSDs are…

Soft Condensed Matter · Physics 2023-12-12 Paul C Bressloff

Spin-transfer-torque magnetic random access memory (STT-MRAM) attracts extensive attentions due to its non-volatility, high density and low power consumption. The core device in STT-MRAM is CoFeB/MgO-based magnetic tunnel junction (MTJ),…

Dissipative Particle Dynamics (DPD) is becoming a popular particle based method to study flow through microchannels due to the ease with which the presence of biological cells or DNA chains can be modeled. Many Lab-On-Chip (LOC) devices…

Fluid Dynamics · Physics 2013-03-27 S. Kumar Ranjith , B. S. V. Patnaik , Srikanth Vedantam

The mechanical properties of PC12 living cells have been studied at the nanoscale with a Force Feedback Microscope using two experimental approaches. Firstly, the local mechanical impedance of the cell membrane has been mapped…

Organic diradicals are envisioned as elementary building blocks for designing a new generation of spintronic devices and have been used in constructing prototypical field effect transistors and non-linear optical devices. Open-shell…

In some d-electron oxides the measured effective mass m(exptl) has long been known to be significantly larger than the model effective mass m(model) deduced from mean-field band theory, i.e., m(exptl) = beta * m(model), where beta > 1 is…

Materials Science · Physics 2021-04-14 Zhi Wang , Oleksandr I. Malyi , Xingang Zhao , Alex Zunger

Electrical stimulation of neural systems is a key tool for understanding neural dynamics and ultimately for developing clinical treatments. Many applications of electrical stimulation affect large populations of neurons. However,…

Neurons and Cognition · Quantitative Biology 2020-11-18 Caglar Cakan , Klaus Obermayer

The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to…

Neurons and Cognition · Quantitative Biology 2019-05-13 Hélène Geoffroy , Jean Rossier , Armelle Rancillac

Considerable mechanistic insight has been gained into amyloid aggregation; however, a large class of non-amyloid protein aggregates are considered 'amorphous,' and in most cases little is known about their mechanisms. Amorphous aggregation…

Spatially confined rigid membranes reorganize their morphology in response to the imposed constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing the deformation energy while compressing a membrane resting…

The necking instability is a precursor to tensile failure and rupture of materials. A quasistatically loaded free-standing uniaxial specimen typically exhibits necking at a single location, corresponding to a long wavelength bifurcation…

Soft Condensed Matter · Physics 2023-01-04 Jian Li , Hannah Varner , Tal Cohen

A longstanding open problem in condensed matter physics is whether or not a strongly disordered interacting insulator can be mapped to a system of effectively non-interacting localized excitations. We investigate this issue on the…

Strongly Correlated Electrons · Physics 2020-05-22 Fahad Mahmood , Dipanjan Chaudhuri , Sarang Gopalakrishnan , Rahul Nandkishore , N. P. Armitage

Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces…

Soft Condensed Matter · Physics 2023-04-20 Siavash Monfared , Guruswami Ravichandran , Jose E. Andrade , Amin Doostmohammadi

Adhesion processes of biological membranes that enclose cells and cellular organelles are essential for immune responses, tissue formation, and signaling. These processes depend sensitively on the binding constant K2D of the…

Biomolecules · Quantitative Biology 2015-11-30 Guang-Kui Xu , Jinglei Hu , Reinhard Lipowsky , Thomas R. Weikl

DFT calculations within the generalized Bloch theorem approach show that interfacial Dzyaloshinskii-Moriya interactions (DMI) at both interfaces of Graphene/Co$_n$/Pt(111) multilayer heterostructures are decoupled for $n \geq 3$. Unlike the…

Materials Science · Physics 2022-09-14 M. Blanco-Rey , G. Bihlmayer , A. Arnau , J. I. Cerda

Mean field models (MFMs) of cortical tissue incorporate salient features of neural masses to model activity at the population level. One of the common aspects of MFM descriptions is the presence of a high dimensional parameter space…

Dynamical Systems · Mathematics 2015-05-19 Federico Frascoli , Lennaert van Veen , Ingo Bojak , David T J Liley

Metasurfaces composed of subwavelength unit cells usually require a large number of unit cells which leads to complicated design and optimization. Aggressive discretization in a metasurface can significantly reduce the number of unit cells…

Applied Physics · Physics 2022-01-13 Chu Qi , Alex M. H. Wong

It is a crucial challenge to reconstruct population dynamics using unlabeled samples from distributions at coarse time intervals. Recent approaches such as flow-based models or Schr\"odinger Bridge (SB) models have demonstrated appealing…

Machine Learning · Statistics 2023-10-06 Tianrong Chen , Guan-Horng Liu , Molei Tao , Evangelos A. Theodorou

Understanding magnetocrystalline anisotropy (MCA) is fundamentally important for developing novel magnetic materials. Therefore, clarifying the relationship between MCA and local physical quantities observed by spectroscopic measurements,…

Materials Science · Physics 2022-10-19 Yoshio Miura , Jun Okabayashi

We present a comprehensive investigation of the magnetic ordering in biphenylene network (BPN) layers, employing density functional theory (DFT) calculations under external perturbations, including uniaxial strains and hole doping. We…

Mesoscale and Nanoscale Physics · Physics 2024-02-21 Sejoong Kim