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Summary: The DynaSig-ML (Dynamical Signatures - Machine Learning) Python package allows the efficient, user-friendly exploration of 3D dynamics-function relationships in biomolecules, using datasets of experimental measures from large…

Biomolecules · Quantitative Biology 2022-07-08 Olivier Mailhot , Francois Major , Rafael Najmanovich

Raman spectroscopy is a non-destructive and label-free chemical analysis technique, which plays a key role in the analysis and discovery cycle of various branches of science. Nonetheless, progress in Raman spectroscopic analysis is still…

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen

Lattice Boltzmann methods are a popular mesoscopic alternative to macroscopic computational fluid dynamics solvers. Many variants have been developed that vary in complexity, accuracy, and computational cost. Extensions are available to…

Mathematical Software · Computer Science 2020-04-14 Martin Bauer , Harald Köstler , Ulrich Rüde

modAL is a modular active learning framework for Python, aimed to make active learning research and practice simpler. Its distinguishing features are (i) clear and modular object oriented design (ii) full compatibility with scikit-learn…

Machine Learning · Computer Science 2018-12-13 Tivadar Danka , Peter Horvath

Large Language Models (LLMs) have become increasingly capable of handling diverse tasks with the aid of well-crafted prompts and integration of external tools, but as task complexity rises, the workflow involving LLMs can be complicated and…

Artificial Intelligence · Computer Science 2024-06-21 Honghua Dong , Qidong Su , Yubo Gao , Zhaoyu Li , Yangjun Ruan , Gennady Pekhimenko , Chris J. Maddison , Xujie Si

This study introduces Ascle, a pioneering natural language processing (NLP) toolkit designed for medical text generation. Ascle is tailored for biomedical researchers and healthcare professionals with an easy-to-use, all-in-one solution…

We introduce the first, general purpose, slice sampling inference engine for probabilistic programs. This engine is released as part of StocPy, a new Turing-Complete probabilistic programming language, available as a Python library. We…

Artificial Intelligence · Computer Science 2015-01-21 Razvan Ranca , Zoubin Ghahramani

Motivation: SBML is the most widespread language for the definition of biochemical models. Although dozens of SBML simulators are available, there is a general lack of support to the integration of SBML models within open-standard…

Molecular Networks · Quantitative Biology 2021-06-07 Filippo Maggioli , Toni Mancini , Enrico Tronci

We introduce TurboGP, a Genetic Programming (GP) library fully written in Python and specifically designed for machine learning tasks. TurboGP implements modern features not available in other GP implementations, such as island and cellular…

Neural and Evolutionary Computing · Computer Science 2023-09-04 Lino Rodriguez-Coayahuitl , Alicia Morales-Reyes , Hugo Jair Escalante

Many tools exist for extracting structural and physiochemical descriptors from linear peptides to predict their properties, but similar tools for hydrocarbon-stapled peptides are lacking.Here, we present StaPep, a Python-based toolkit…

Biomolecules · Quantitative Biology 2024-02-29 Zhe Wang , Jianping Wu , Mengjun Zheng , Chenchen Geng , Borui Zhen , Wei Zhang , Hui Wu , Zhengyang Xu , Gang Xu , Si Chen , Xiang Li

We present SPDL (Scalable and Performant Data Loading), an open-source, framework-agnostic library designed for efficiently loading array data to GPU. Data loading is often a bottleneck in AI applications, and is challenging to optimize…

Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system under several conditions -- for example, with various mutations or bound…

Biomolecules · Quantitative Biology 2025-01-07 Martin Vögele , Neil J. Thomson , Sang T. Truong , Jasper McAvity , Ulrich Zachariae , Ron O. Dror

Scientific computation is a discipline that combines numerical analysis, physical understanding, algorithm development, and structured programming. Several yottacycles per year on the world's largest computers are spent simulating problems…

Programming Languages · Computer Science 2018-01-10 Matthew G. Knepley

Aggregate programming is a field-based coordination paradigm with over a decade of exploration and successful applications across domains including sensor networks, robotics, and IoT, with implementations in various programming languages,…

Software Engineering · Computer Science 2026-04-01 Gianluca Aguzzi , Davide Domini , Nicolas Farabegoli , Mirko Viroli

We introduce BlaBla, an open-source Python library for extracting linguistic features with proven clinical relevance to neurological and psychiatric diseases across many languages. BlaBla is a unifying framework for accelerating and…

Computation and Language · Computer Science 2020-05-21 Abhishek Shivkumar , Jack Weston , Raphael Lenain , Emil Fristed

This chapter provides a brief introduction to the theory and practice of spatial stochastic simulations. It begins with an overview of different methods available for biochemical simulations highlighting their strengths and limitations.…

Quantitative Methods · Quantitative Biology 2018-10-02 Sanjana Gupta , Jacob Czech , Robert Kuczewski , Thomas M. Bartol , Terrence J. Sejnowski , Robin E. C. Lee , James R. Faeder

Online data streams make training machine learning models hard because of distribution shift and new patterns emerging over time. For natural language processing (NLP) tasks that utilize a collection of features based on lexicons and rules,…

Computation and Language · Computer Science 2022-11-28 Shubhanshu Mishra , Jana Diesner

Particle-in-cell methods couple mesh-based methods for the solution of continuum mechanics problems, with the ability to advect and evolve particles. They have a long history and many applications in scientific computing. However, they have…

Numerical Analysis · Mathematics 2019-09-12 R. Gassmoeller , E. Heien , E. G. Puckett , W. Bangerth

The use of Python is noticeably growing among the scientific community, and Astronomy is not an exception. The power of Python consists of being an extremely versatile high-level language, easy to program that combines both traditional…

Instrumentation and Methods for Astrophysics · Physics 2018-07-16 Daniel M. Faes