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Understanding the dynamics of large-scale brain models remains a central challenge due to the inherent complexity of these systems. In this work, we explore the emergence of complex spatiotemporal patterns in a large scale-brain model…

Neurons and Cognition · Quantitative Biology 2025-12-04 Rosa Maria Delicado , Gemma Huguet , Pau Clusella

The recent development of genetically encoded calcium indicators enables monitoring in vivo the activity of neuronal populations. Most analysis of these calcium transients relies on linear regression analysis based on the sensory stimulus…

Neurons and Cognition · Quantitative Biology 2014-09-10 Fabrizio De Vico Fallani , Martina Corazzol , Jenna R. Sternberg , Claire Wyart , Mario Chavez

Biological neural circuits contain specialized substructures that support distinct computational functions, yet many bio-inspired neural networks borrow biological motifs without identifying their circuit-level origins. In this study, we…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Ningping Li , Hao Zhang , Yi Zhou

Many neuronal systems and models display a certain class of mixed mode oscillations (MMOs) consisting of periods of small amplitude oscillations interspersed with spikes. Various models with different underlying mechanisms have been…

Adaptation and Self-Organizing Systems · Physics 2015-03-13 Peter Borowski , Rachel Kuske , Yue-Xian Li , Juan Luis Cabrera

Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…

Neurons and Cognition · Quantitative Biology 2023-02-08 Yorgos M. Psarellis , Michail Kavousanakis , Michael A. Henson , Ioannis G. Kevrekidis

Blebs are cell protrusions generated by local membrane-cortex detachments followed by expansion of the plasma membrane. Blebs are formed by some migrating cells, for example primordial germ cells of the zebrafish. While blebs occur randomly…

Analysis of PDEs · Mathematics 2019-12-19 Carolin Dirks , Paul Striewski , Benedikt Wirth , Anne Aalto , Adan Olguin-Olguin , Erez Raz

Biological systems represent time from microseconds to years. An important gap in our knowledge concerns the mechanisms for encoding time intervals of hundreds of milliseconds to minutes that matter for tasks like navigation, communication,…

Neurons and Cognition · Quantitative Biology 2025-05-22 Raphaël Lafond-Mercier , Leonard Maler , Avner Wallach , André Longtin

This paper considers generalised network, intended as networks where (a) the edges connecting the nodes are nonlinear, and (b) stochastic processes are continuously indexed over both vertices and edges. Such topological structures are…

Social and Information Networks · Computer Science 2023-09-29 Tobia Filosi , Claudio Agostinelli , Emilio Porcu

Spatially-embedded complex networks, such as nervous systems, the Internet and transportation networks, generally have non-trivial topological patterns of connections combined with nearly minimal wiring costs. However the growth rules…

Physics and Society · Physics 2013-05-09 Vincenzo Nicosia , Petra E. Vértes , William R. Schafer , Vito Latora , Edward T. Bullmore

Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can…

Subcellular Processes · Quantitative Biology 2019-06-19 Jingyu Zhang , Hengyu Chen , Ruoyan Li , David A. Taft , Guang Yao , Fan Bai , Jianhua Xing

Transients are fundamental to ecological systems with significant implications to management, conservation, and biological control. We uncover a type of transient synchronization behavior in spatial ecological networks whose local dynamics…

Populations and Evolution · Quantitative Biology 2020-11-24 Huawei Fan , Ling-Wei Kong , Xingang Wang , Alan Hastings , Ying-Cheng Lai

Dynamical coherent structure (pattern) formation in the Klein-Gordon lattice excited by periodic external field near the optical resonance is studied. It is shown that besides spatial patterns discovered recently (V.M.Burlakov,…

patt-sol · Physics 2009-10-31 Victor M. Burlakov

A genetic switch may be realised by a certain operator sector on the DNA strand from which either genetic code, to the left or to the right of this operator sector, can be transcribed and the corresponding information processed. This switch…

Statistical Mechanics · Physics 2013-01-24 Ralf Metzler

Pattern dynamics triggered by fixing a boundary is investigated. By considering a reaction-diffusion equation that has a unique spatially-uniform and limit cycle attractor under a periodic or Neumann boundary condition, and then by choosing…

Pattern Formation and Solitons · Physics 2018-05-09 Takahiro Kohsokabe , Kunihiko Kaneko

Flocks of birds and schools of fish are familiar examples of spatial patterns formed by living organisms. In contrast to the patterns on the skins of, say, zebra and giraffe, the patterns of our interest are {\it transient} although…

Populations and Evolution · Quantitative Biology 2007-05-23 Debashish Chowdhury , Katsuhiro Nishinari , Andreas Schadschneider

I show the assumed Bilayer structure of cell membranes is Topologically falsified by known aminophospholipid dynamics in metabolically-active, Far from Equilibrium cells. The sensitivity of lipid and cytoplasmic flows to temperature,…

Biological Physics · Physics 2011-11-09 J. T. Lofthouse

Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…

Neurons and Cognition · Quantitative Biology 2011-05-09 Paul Expert , Renaud Lambiotte , Dante R. Chialvo , Kim Christensen , Henrik Jeldtoft Jensen , David J. Sharp , Federico Turkheimer

The origins of spontaneous movements have been investigated in human as well as in other vertebrates. Studies have reported an increase in neuronal activity one second before the onset of a given movement: this is known as readiness…

Neurons and Cognition · Quantitative Biology 2020-12-22 Selma Mehyaoui

Throughout developmental biology and ecology, transport can be driven by nonlocal interactions. Examples include cells that migrate based on contact with pseudopodia extended from other cells, and animals that move based on their vision of…

Pattern Formation and Solitons · Physics 2023-07-07 Thomas Jun Jewell , Andrew L. Krause , Philip K. Maini , Eamonn A. Gaffney

The detailed reconstruction of neural anatomy for connectomics studies requires a combination of resolution and large three-dimensional data capture provided by serial section electron microscopy (ssEM). The convergence of high throughput…

Computer Vision and Pattern Recognition · Computer Science 2017-11-21 Arthur W. Wetzel , Jennifer Bakal , Markus Dittrich , David G. C. Hildebrand , Josh L. Morgan , Jeff W. Lichtman