Quantitative Biology
Truncus arteriosus (TA) is a rare and severe congenital heart disease. Quadricuspid valve morphology occurs in 25% of all TA patients and is linked to regurgitation and increased risk of re-operation. It remains unclear how hemodynamic…
This paper gives an in-depth theoretical analysis of the direction and speed selectivity properties of idealized models of the spatio-temporal receptive fields of simple cells and complex cells, based on the generalized Gaussian derivative…
Mapping habitat suitability, based on factors like host availability and environmental suitability, is a common approach to determining which locations are important for the spread of a species. Mapping habitat connectivity takes geographic…
Turning rich neuroimaging data into mechanistic insight remains challenging. Statistical models capture associations but remain largely agnostic to underlying mechanisms. Biophysical models embody candidate mechanisms but remain difficult…
Classifying Antimicrobial Peptides (AMPs) from the vast collection of peptides derived from metagenomic sequencing offers a promising avenue for combating antibiotic resistance. However, most existing AMP classification methods rely…
Sweepstakes reproduction refers to a highly skewed individual recruitment success without involving natural selection and may apply to individuals in broadcast spawning populations characterised by Type III survivorship. We consider an…
The coupled Arctic system is in rapid transition and is set to undergo further dramatic changes over the coming decades. These changes will lead most likely to an ice-free ocean in summer, expected before mid-century. The Arctic will become…
Background:Subject-specific finite element analysis accurately characterizes knee joint mechanics but is computationally expensive. Deep surrogate models provide a rapid alternative, yet their generalization across subjects under limited…
Selective attention can momentarily alter visual appearance, but can such effects be learned? We tested whether training attention under sensory competition produces lasting changes in perceived contrast. Across seven days, participants…
This study was carried out to evaluated the effects of soaking duration and rooting substrate on the root and shoot development of Salakhani pomegranate hardwood cuttings. The experiment was conducted at Darbandikhan Technical Institute,…
Dietary flavonoids associate with disease prevention in epidemiological studies, yet their polypharmacological mechanisms remain unclear. We establish network pharmacology as a systematic framework to characterize flavonoid therapeutic…
Nearest-neighbor(NN) free energy parameters for DNA are well studied and reliable values of these parameters exist in the literature. They have been found to be very useful in studying DNA melting and DNA stabilization studies. In this…
Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT…
Biofilms in human tonsillar crypts show long term persistence with episodic dispersal that current biochemical and microbiological descriptions do not fully explain, particularly with respect to spatial localization. We introduce a…
Post-acute sequelae of SARS-CoV-2 infection (Long COVID) frequently persists for months, yet drivers of clinical remission remain incompletely defined. Here we analyzed 97,564 longitudinal PASC assessments from 13,511 participants with…
Micronutrient deficiency in soils limits crop productivity and reduces the nutritional quality of cereals and pulses. Conventional fertilizer supplementation often suffers from low bioavailability and environmental losses. In this study, we…
Differentiating between the two main subtypes of Inflammatory Bowel Disease (IBD): Crohns disease (CD) and ulcerative colitis (UC) is a persistent clinical challenge due to overlapping presentations. This study introduces a novel…
Human cooperation persists among strangers in large, well-mixed populations despite theoretical predictions of difficulties, leaving a fundamental evolutionary puzzle. While upstream (pay-it-forward: helping others because you were helped)…
Learning is based on synaptic plasticity, which affects and is driven by neural activity. Because pre- and postsynaptic spiking activity is shaped by randomness, the synaptic weights follow a stochastic process, requiring a probabilistic…
Effective public health decisions require early reliable inference of infectious disease properties. In this paper we assess the ability to infer infectious disease attributes from population-level stochastic epidemic trajectories. In…