Quantitative Biology
Perturbation screens hold the potential to systematically map regulatory processes at single-cell resolution, yet modeling and predicting transcriptome-wide responses to perturbations remains a major computational challenge. Existing…
Population heterogeneity is a key factor in epidemic dynamics, influencing both transmission and final epidemic size. While heterogeneity is often modelled through age structure, spatial location, or contact patterns, differences in host…
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature B cells arise. It is known that B cells…
Understanding convergent learning -- the degree to which independently trained neural systems -- whether multiple artificial networks or brains and models -- arrive at similar internal representations -- is crucial for both neuroscience and…
Mesoscopic models of finite-size neuronal populations are crucial to understand the dynamics of neural networks in the brain, especially their fluctuations and response to stimuli. However, current theories to derive such models are based…
The complexity of molecular and cellular processes forces experimental studies to focus on subsystems. To study the functioning of biological systems across levels of structural and functional organisation, we require tools to compose and…
The problem of explaining the relationship between subjective experience and physical reality remains difficult and unresolved. In most explanations, consciousness is epiphenomenal, without causal power. The most notable exception is…
Genome variants which re-occur independently across evolutionary lineages are key molecular signatures of adaptation. Inferring the dynamics of such genetic changes from pandemic-scale genomic datasets is now possible, which opens up…
Bacteriophages (phages) are key regulators of bacterial populations and hold great promise for applications such as phage therapy, biocontrol, and industrial fermentation. The success of these applications depends on accurately determining…
Physics relies on mathematical spaces carefully matched to the phenomena under study. Phase space in classical mechanics, Hilbert space in quantum theory, configuration spaces in field theory all provide representations in which physical…
We study the ChorHendySnir2006 evolutionary model, which consists of a rooted phylogenetic tree with three leaves, subject to the Jukes--Cantor (JC69) molecular evolutionary model and molecular clock. We show that the likelihood function…
This study presents the first large-scale empirical evaluation of quantum machine learning for predicting antibiotic resistance in clinical urine cultures. Antibiotic resistance is amongst the top threats to humanity, and inappropriate…
Strong, correlated noise in recurrent neural circuits often passes through nonlinear transfer functions, complicating dynamical mean-field analyses of complex phenomena such as transients and bifurcations. We introduce a method that…
We consider a SIRD epidemic model for a population composed of two groups of individuals with asymmetric interactions, where the force of infection depends on the active (alive) population in each group, rather than on the total population,…
Collective movement is observed widely in nature, where individuals interact locally to produce globally ordered, coherent motion. In typical models of collective motion, each individual takes the average direction of multiple neighbors,…
Precision psychiatry aspires to elucidate brain-based biomarkers of psychopathology to bolster disease risk assessment and treatment development. To this end, functional magnetic resonance imaging (fMRI) has helped triangulate brain…
Continuous attractor networks (CANs) are a well-established class of models for representing low-dimensional continuous variables such as head direction, spatial position, and phase. In canonical spatial domains, transitions along the…
Background: Conventional electrocardiogram (ECG) analysis faces a persistent dichotomy: expert-driven features ensure interpretability but lack sensitivity to latent patterns, while deep learning offers high accuracy but functions as a…
Ventriloquism After-Effect is the phenomenon where sustained exposure to the ventriloquist illusion causes a change in unisensory auditory localization towards the location where the visual stimulus was present. We investigate the…
We present a mathematical and philosophical framework in which brain function is modeled using sheaf theory over neural state spaces. Local neural or cognitive functions are represented as sections of a sheaf, while global coherence…