Quantitative Biology
Cellular differentiation is governed by gene regulatory networks, the high-dimensional stochastic biochemical systems that determine the transcriptional landscape and mediate cellular responses to signals and perturbations. Although…
Tuberculosis (TB) is an airborne disease caused by the pathogen Mycobacterium tuberculosis. In 2023, according to the World Health Organization, it ''probably'' replaced COVID-19 as the leading cause of death from an infectious agent…
Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling complex diseases from biomedical data is…
Computational molecular design requires binding arrangements that are not only energetically favorable but also chemically realizable. However, computational methods remain limited in directly recovering fragment pose pairs that can later…
Trans-membrane gradients and fluxes of cations (H+, Na+, K+, etc.) were deemed to be the rationale of electrical activities of aerobic cells/organelles, as per classical perceptions. Murburn concept (an umbrella of theorization based in…
Modern optical microscopes are fully motorised; however, transforming them into truly smart systems requires real-time adjustment of acquisition settings in response to detected objects and dynamic biological events. At the core are…
A cornerstone of our understanding of both biological and artificial neural networks is that they store information in the strengths of synaptic connections among the neurons. However, in contrast to the well-established theory for…
Immunoaffinity-based liquid biopsies of circulating tumor cells (CTCs) hold great promise for cancer management, but typically suffer from low throughput, relative complexity and post-processing limitations. Here we address these issues…
Melanoma is an aggressive form of skin cancer. Survival rates are excellent if it is detected early but fall markedly if it metastasises. A key step in early tumour progression is the formation of cell clusters, which can promote…
Functional connectivity varies across individuals due to genetic and environmental factors, yet classical twin models typically confound non-shared environment with measurement error and are largely limited to resting-state analyses. We…
Periods of low dissolved oxygen concentration -- hypoxia and anoxia -- threaten the health of aquatic ecosystems and the services they provide.Hypoxia is strongly influenced by temperature, but the different sensitivities and response…
Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…
Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…
Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns of association among microbial gene…
Tongue squamous cell carcinoma (TSCC) is an aggressive malignancy with marked biological heterogeneity and variable clinical outcomes. Although molecular profiling has improved understanding of TSCC heterogeneity, its clinical use remains…
The relationship between brain lateralization and cognitive functions is well-documented. The left hemisphere primarily handles tasks such as language and arithmetic, while the right hemisphere is involved in creative activities like…
The foundation of cognitive flexibility and higher-order intelligence lies in the functional structure and activity of brain networks, which can be dynamically configured by both external environments and internal states. However, decoding…
Collective decision-making arises from individual agents integrating their own personal observations with information obtained from social partners. In many biological systems that exhibit collective decision-making, the process by which…
Compartmental epidemic models, grounded in mass-action kinetics, often assume homogeneous mixing. Although this neglects network structure, recent results show that for Poisson random graphs, the classical SIR model, especially the…
Progress in vision research has been slower downstream than upstream of primary visual cortex (V1). Traditional frameworks have largely overlooked a central constraint: only a tiny fraction of retinal input is recognized. Thus, to a first…