Quantitative Biology
The visual systems of birds and mammals exhibit remarkable organizational similarities: the dorsal ventricular ridge (DVR) demonstrates a columnar microcircuitry that parallels the cortical architecture observed in mammals. However, the…
Lateral flow immunoassays (LFIA) are among the most widely used rapid diagnostic tests for point-of-care screening of disease biomarkers. However, their limited sensitivity hinders their use in complex clinical applications that require…
BACKGROUND: Primary aldosteronism is the most common form of secondary hypertension. The most frequent genetic cause of aldosterone-producing adenomas is somatic mutations in the potassium channel KCNJ5. They affect the ion selectivity of…
Multisite protein phosphorylation plays a pivotal role in regulating cellular signaling and decision-making processes. In this study, we focus on the mathematical underpinnings and informational aspects of sequential, distributive…
This study proposes a new method for computing transpiration across an eddy covariance footprint using field observations of plant sap flow, phytomorphology sampling, uncrewed aerial system (UAS), deep learning-based digital image…
Kinetic parameters such as the turnover number ($k_{cat}$) and Michaelis constant ($K_{\mathrm{M}}$) are essential for modelling enzymatic activity but experimental data remains limited in scale and diversity. Previous methods for…
A major locus of musicological activity-increasingly in the digital domain-is the cataloguing of sources, which requires large-scale and long-lasting research collaborations. Yet, the databases aiming at covering and representing musical…
Humans perceive their visual environment by directing their eyes towards relevant objects. The deployment of visual attention depends substantially on the stimulus's properties, higher cognitive processes, and biases and constraints of the…
Plastics are essential to modern life, yet poor disposal practices contribute to low recycling rates and environmental accumulation-biological degradation and by-product reuse offer a path to mitigate this global threat. This report…
Membrane protein classification is a fundamental task in structural bioinformatics, critical to understanding protein functions and accelerating drug discovery. In this study, we propose MP-GCAN, a novel graph-based classification model…
Auditory streaming enables the brain to organize sequences of sounds into perceptually distinct sources, such as following a conversation in a noisy environment. A typical experiment for investigating perceptual boundaries and bistability…
The recent breakthrough of AlphaFold3 in modeling complex biomolecular interactions, including those between proteins and ligands, nucleotides, or metal ions, creates new opportunities for protein design. In so-called inverse protein…
Mobile genetic elements (e.g., endogenous viruses, LINEs, SINEs) can transfer between genomes, even between species, triggering dramatic genetic changes. Endogenous viral elements (EVEs) arise when infectious viruses integrate into the host…
Recent studies have made great progress in functional brain network classification by modeling the brain as a network of Regions of Interest (ROIs) and leveraging their connections to understand brain functionality and diagnose mental…
Epilepsy surgery, particularly for temporal lobe epilepsy (TLE), remains a vital treatment option for patients with drug-resistant seizures. However, accurately predicting surgical outcomes remains a significant challenge. This study…
Sterile Insect Technique (SIT) is a promising control method against insect pests and insect vectors. It consists in releasing males previously sterilized in laboratory, in order to reduce or eliminate a specific wild population. We study…
Dreams offer a unique window into the cognitive and affective dynamics of the sleeping and the waking mind. Recent quantitative linguistic approaches have shown promise in obtaining corpus-level measures of dream sentiment and topic…
Here we demonstrate the first biochemistry-agnostic approach to map evolutionary relationships at the molecular scale, allowing the construction of phylogenetic models using mass spectrometry (MS) and Assembly Theory (AT) without…
The remarkable structural diversity of modern proteins reflects millions of years of evolution, during which sequence space has expanded while many structural features remain conserved. This conservation is evident not only among homologous…
The myriad microscopic interactions among the individual organisms that constitute an ecological system collectively give rise, at the macroscopic scale, to evolutionary trends. The ability to detect the directionality of such trends is…