Quantitative Biology
Diagnosing sleep disorders is an important focus in neuroscience and engineering, as these conditions involve issues such as insufficient sleep, frequent awakenings, and difficulty reaching deep sleep. Accurate detection based on brain…
A fundamental challenge in microbial ecology is determining whether bacteria compete or cooperate in different environmental conditions. With recent advances in genome-scale metabolic models, we are now capable of simulating interactions…
Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…
Populations experience a complex interplay of continuous and discrete processes: continuous growth and interactions are punctuated by discrete reproduction events, dispersal, and external disturbances. These dynamics can be modeled by…
Stochastic systems have a control-theoretic interpretation in which noise plays the role of control. In the weak-noise limit, relevant at low temperatures or in large populations, this leads to a precise mathematical mapping: the most…
When studying a complex system it is often useful to think of the system as a network of interacting units. One can then ask if some properties of the entire network are already explained by a small part of the network - a network motif. A…
A general system of difference equations is presented for multispecies communities with density dependent population growth and delayed maturity. Interspecific competition, mutualism, predation, commensalism, and amensalism are…
Firing rate models are dynamical systems widely used in applied and theoretical neuroscience to describe local cortical dynamics in neuronal populations. By providing a macroscopic perspective of neuronal activity, these models are…
Background: Mathematical models based on ordinary differential equations (ODEs) are essential tools across various scientific disciplines, including biology, ecology, and healthcare informatics. They are used to simulate complex dynamic…
Behaviour change lies at the heart of many observable collective phenomena such as the transmission and control of infectious diseases, adoption of public health policies, and migration of animals to new habitats. Representing the process…
Neural electrical activity is fundamental to brain function, underlying a range of cognitive and behavioral processes, including movement, perception, decision-making, and consciousness. Abnormal patterns of neural signaling often indicate…
Small and large scale pandemics are a natural phenomenon repeatably appearing throughout history, causing ecological and biological shifts in ecosystems and a wide range of their habitats. These pandemics usually start with a single strain…
To better predict the dynamics of epidemics such as COVID-19, it is important not only to investigate the network of local and long-range contagious contacts but also to understand the temporal dynamics of infectiousness and detectable…
Since the earliest electroencephalography experiments, large scale oscillations have been observed in the mammalian brain. More recently, episodes of oscillation and bursting have been identified not only in the cerebral cortex and…
Biomedical knowledge graphs (KGs) are widely used across research and translational settings, yet their design decisions and implementation are often opaque. Unlike ontologies that more frequently adhere to established creation principles,…
Over the past decade, techniques enabling bidirectional modulation of neuronal activity with single cell precision have rapidly advanced in the form of two-photon optogenetic stimulation. Unlike conventional electrophysiological approaches…
During fieldwork in Thailand we observed nearly identical frequencies of co-located flashing fireflies and chirping crickets. Motivated by this, we perform a meta-analysis and show an abundance of evolutionarily distinct species that…
Cryptochrome flavoproteins are prime candidates for mediating magnetic sensing in migratory animals via the radical pair mechanism (RPM), a spin-dependent process initiated by photoinduced electron transfer. The canonical FAD-tryptophan…
Efficient information processing is crucial for both living organisms and engineered systems. The mutual information rate, a core concept of information theory, quantifies the amount of information shared between the trajectories of input…
Human metapneumovirus (hMPV) poses serious risks to pediatric, elderly, and immunocompromised populations. Traditional antibody discovery pipelines require 10-12 months, limiting their applicability for rapid outbreak response. This project…