Quantitative Biology
The objective of this paper is to review physiological and computational aspects of the responsiveness of the cerebral cortex to stimulation, and how responsiveness depends on the state of the system. This correspondence between brain state…
Why do human populations remain vulnerable to collapse, even when they are large? Classical demographic theory predicts that volatility in growth should decline rapidly with size due to the averaging effects of the law of large numbers. As…
The forces generated by action potentials in muscle cells shuttle blood, food and waste products throughout the luminal structures of the body. Although non-invasive electrophysiological techniques exist, most mechanosensors cannot access…
Understanding how the primate brain transforms complex visual scenes into coherent perceptual experiences remains a central challenge in neuroscience. Here, we present a comprehensive framework for interpreting monkey visual processing by…
Members of the Rumex genus possess allelochemical compounds that vary depending on the plant part and extract concentrations. Therefore, this study aimed to investigate the allelopathic effects of extracts from the roots, stems, and leaves…
Early recurrence (ER) prediction after curative-intent resection remains a critical challenge in the clinical management of hepatocellular carcinoma (HCC). Although contrast-enhanced computed tomography (CT) with full multi-phase…
Surgical video datasets are essential for scene understanding, enabling procedural modeling and intra-operative support. However, these datasets are often heavily imbalanced, with rare actions and tools under-represented, which limits the…
Wuchereria bancrofti, the parasitic roundworm responsible for lymphatic filariasis, permanently disables over 36 million people and places 657 million at risk across 39 countries. A major bottleneck for drug discovery is the lack of…
NeuroAI is an emerging field at the intersection of neuroscience and artificial intelligence, where insights from brain function guide the design of intelligent systems. A central area within this field is synthetic biological intelligence…
Oscillatory chemical reactions are functional components in a variety of biological contexts. In chemistry, the construction and identification of even rudimentary oscillators remain elusive and lack a general framework. Using…
Social perception unfolds as we freely interact with people around us. We investigated the neural basis of real world face perception using multi electrode intracranial recordings in humans during spontaneous interactions with friends,…
Large Language Models (LLMs) and LLM-based agents show great promise in accelerating scientific research. Existing benchmarks for measuring this potential and guiding future development continue to evolve from pure recall and rote knowledge…
Category-selective regions in the human brain-such as the fusiform face area (FFA), extrastriate body area (EBA), parahippocampal place area (PPA), and visual word form area (VWFA)-support high-level visual recognition. Here, we investigate…
Molecular sequence analysis is crucial for comprehending several biological processes, including protein-protein interactions, functional annotation, and disease classification. The large number of sequences and the inherently complicated…
Ancestral recombination graphs (ARGs) encode the complete genealogical history of a population of recombining lineages. ARGs, and their succinct representation, tree sequences, are increasingly central to modern population genetics methods,…
By introducing the twin concepts of reliability and precision along with the corresponding measures, Mainen and Sejnowski's seminal 1995 paper "Reliability of spike timing in neocortical neurons" (Mainen and Sejnowski, 1995) paved the way…
Functional variability in both gray matter (GM) and white matter (WM) is closely associated with human brain cognitive and developmental processes, and is commonly assessed using functional connectivity (FC). However, as a correlation-based…
Hidden hearing loss, or cochlear neural degeneration (CND), disrupts suprathreshold auditory coding without affecting clinical thresholds, making it difficult to diagnose. We present an information-theoretic framework to evaluate speech…
Protein sequence alignment is a cornerstone of bioinformatics, traditionally approached using dynamic programming (DP) algorithms that find an optimal sequential path. This paper introduces UniOTalign, a novel framework that recasts…
Far from equilibrium, neural systems self-organize across multiple scales. Exploiting multiscale self-organization in neuroscience and artificial intelligence requires a computational framework for modeling the effective non-equilibrium…