Tissues and Organs
We develop a minimal whole-heart model that describes cardiac electrical conduction and simulate a basic three-lead electrocardiogram (ECG). We compare our 3-lead ECG model with clinical data from a Norwegian athlete database. The results…
The refractory period and conduction delay of the atrioventricular (AV) node play a crucial role in regulating the heart rate during atrial fibrillation (AF). Beat-to-beat variations in these properties are known to be induced by the…
The revelation of the supreme authority of nucleic acids in the cellular landscape has precipitated the recognition of the versatility of RNAs in cells. The subsequent discovery of non-coding RNAs was a major breakthrough that revealed…
Background and Aim: Decellularized uterine extracellular matrix (dUECM) offers a promising bioactive scaffold for uterine tissue engineering, but its application in 3D constructs has been limited by fabrication challenges. This study aimed…
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction…
Objective: Severe congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a promising repair technique with acceptable durability.…
Healing of Tendon-bone interface(TBI) injuries is slow and is often repaired with scar tissue formation that compromises normal function. Despite the increasing maturity of surgical techniques, re-tearing of the rotator cuff after surgery…
Research on human skin anatomy reveals its complex multi-scale, multi-phase nature, with up to 70% of its composition being bounded and free water. Fluid movement plays a key role in the skin's mechanical and biological responses,…
The main goal from this study is to discuss the main features of Artificial intelligence (AI) as well as their applicability for early cardiovascular Disease (CVDs) Detection, Material and Method : Systematic review approach Results : It…
Computational inverse problems for biomedical simulators suffer from limited data and relatively high parameter dimensionality. This often requires sensitivity analysis, where parameters of the model are ranked based on their influence on…
Computational hemodynamics models are becoming increasingly useful in the management and prognosis of complex, multiscale pathologies, including those attributed to the development of pulmonary vascular disease. However, diseases like…
The identification and validation of therapeutic antibodies is critical for developing effective treatments for many diseases. We present a computational approach for identifying antibodies targeting GFRAL-specific receptors, receptors…
The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and…
This paper proposes a hypothetical model for the dual role of respiratory aerosols and inflammatory exudates in the dynamics and progression of SARS-CoV-2 lung infection. Starting from a new paradigm in infectious disease transmission, we…
The work presents a study of the non-linear mathematical model of tumor growth, proposed by Kolev and Zubik-Kowal (2011). The model is described by a system composed of four partial differential equations that represent the evolution of the…
Zebrafish have been used as a model organism in many areas of biology, including the study of pattern formation. The mean-field survival model is a coupled ODE system describing the expected evolution of chromatophores coordinating to form…
We envision the "virtual eye" as a next-generation, AI-powered platform that uses interconnected foundation models to simulate the eye's intricate structure and biological function across all scales. Advances in AI, imaging, and multiomics…
A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…
Functional limitation after lung resection surgery has been consistently documented in clinical studies, and right ventricle (RV) dysfunction has been hypothesized as a contributing reason. However, the mechanisms of RV dysfunction after…
Accurate surgical instrument segmentation is essential in cataract surgery for tasks such as skill assessment and workflow optimization. However, limited annotated data makes it difficult to develop fully automatic models. Prompt-based…