Tissues and Organs
Solute transport is modeled using mixture theory, applied to the nanoparticle accumulation and concentration decay in the tissue space for different vascular configurations. A comparison of a single capillary configuration (SBC) with two…
The alignment of cell-cell junctions and associated cortical actomyosin across multiple cells to form supracellular cables in an epithelium is an example of the long range tissue organization that drives morphogenesis. Here we demonstrate…
Chondrocytes were described as one cell populations in most cartilage literature. Two different chondrocyte populations; dark and light, were described in the articular cartilage and a third population, adipochondrocytes, was described in…
Polyp has long been considered as one of the major etiologies to colorectal cancer which is a fatal disease around the world, thus early detection and recognition of polyps plays a crucial role in clinical routines. Accurate diagnoses of…
Cardiac re-entry regime of self-organised abnormal synchronisation underlie dangerous arrhythmias and fatal fibrillation. Recent advances in the theory of dissipative vortices, experimental studies, and anatomically realistic computer…
The characterization of heart dynamics with a view to distinguish abnormal from normal behavior is an interesting topic in clinical sciences. Here we present an analysis of the Electro-cardiogram (ECG) signals obtained under controlled…
To accelerate the development of strategies for cartilage tissue engineering, models are necessary to study the interactions between cellular dynamics and scaffold (SC) porosity. In experiments, cells are seeded in a porous SC where over a…
Response of the mechanoreceptors underlying the skin is greatly affected by its mechanical properties. Knowledge of this response is essential in designing artificial tactile devices such as minimally invasive tools and tactile displays.…
Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and…
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that…
Multimorbidities are associated with significant burden on the healthcare system and the lack of accurate and pertinent statistical exploratory techniques have often limited their analysis. Here we employ exploratory hierarchal…
Fickian diffusion into a core-shell geometry is modeled. The interior core mimics pancreatic Langerhan islets and the exterior shell acts as inert protection. The consumption of oxygen diffusing into the cells is approximated using…
We introduce a particle-based model of self-replicating cells on a deformable substrate composed of the dermis and the basement membrane and investigate the relationship between dermal deformations and stem cell pattering on it. We show…
Quasi-static, pulmonary pressure-volume (P-V) curves over an inflation-deflation cycle are analyzed using a respiratory system model (RSM), which had been developed for quantitative characterization of the mechanical behavior of the total…
Unlike other organs, the thymus and gonads generate non-uniform cell populations, many members of which perish, and a few survive. While it is recognized that thymic cells are 'audited' to optimize an organism's immune repertoire, whether…
Bone healing process includes four phases: inflammatory response, soft callus formation, hard callus development, and remodeling. Mechanobiological models have been used to investigate the role of various mechanical and biological factors…
We developed and applied rapid scanning laser-emission microscopy to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors. Regulation of chromatins is essential for genetic development and normal cell…
Critically sized defects are currently treated via autologous or allograft bone grafting, distraction osteogenesis, and membrane induction. However, these methods have major weaknesses which encourage the development of synthetic bone graft…
Background Computer-based geometrical meshes of bones are important for applications in computational biomechanics as well as clinical software. There is however a lack of freely available detailed bone meshes, especially related to the…
In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding…