Cell Behavior
A human watching a video of closely-packed cells can generally identify every individual cell, regardless of density and noise, but most currently-available cell-tracking software cannot. This is because the human brain automatically builds…
We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell…
Collective sensing by interacting cells is observed in a variety of biological systems, and yet a quantitative understanding of how sensory information is collectively encoded is lacking. Here we investigate the ATP-induced calcium dynamics…
Following antigen stimulation, the net outcomes of a T cell response are shaped by integrated signals from both positive co-stimulatory and negative regulatory molecules. Recently, the blockade of negative regulatory molecules (i.e. immune…
In order to better understand the mechanisms underlying the physiology of vision, it is a necessary prerequisite to know the embryological bases of eye development and associated tissues. Eye formation starts during the fourth week of human…
Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular…
We introduce a model for ionic electrodiffusion and osmotic water flow through cells and tissues. The model consists of a system of partial differential equations for ionic concentration and fluid flow with interface conditions at deforming…
Using a popular vertex-based model to describe a spatially disordered planar epithelial monolayer, we examine the relationship between cell shape and mechanical stress at the cell and tissue level. Deriving expressions for stress tensors…
"Secrete-and-sense cells" can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially "talk" to itself ("self-communication") or talk to neighboring cells with the…
In population biology, the Allee dynamics refer to negative growth rates below a critical population density. In this Letter, we study a reaction-diffusion (RD) model of population growth and dispersion in one dimension, which incorporates…
The view that ROS slow down aging is getting popular. We here proposed an idea that aging is slowed down by secondary responses rather than ROS.
We examined the pH/$T$ (or $\mu$/$T$) duality of acidic pH and temperature ($T$) for the growth of grass shoots in order to determine the equation of state (EoS) for living plants. By considering non-meristematic growth as a dynamic series…
We recently found that marine bacteria Vibrio alginolyticus execute a cyclic 3-step (run- reverse-flick) motility pattern that is distinctively different from the 2-step (run-tumble) pattern of Escherichia coli. How this novel swimming…
Biofilms are communities of bacteria that exhibit a multitude of multiscale biomechanical behaviors. Recent experimental advances have lead to characterizations of these behaviors in terms of measurements of the viscoelastic moduli of…
Stochastic resonance induced by external factor is considering to investigate the complex dynamics of tumor. The surrounding environment and the treatment effects on the tumor growth are considered as additive and multiplicative noises in…
Intracellular Ca signals represent a universal mechanism of cell function. Messages carried by Ca are local, rapid, and powerful enough to be delivered over the thermal noise. A higher signal to noise ratio is achieved by a cooperative…
Cells crawling through tissues migrate inside a complex fibrous environment called the extracellular matrix (ECM), which provides signals regulating motility. Here we investigate one such well-known pathway, involving mutually antagonistic…
Hydrogen peroxide (H2O2) is an important signaling molecule in cancer cells. However, the significant secretion of H2O2 by cancer cells have been rarely observed. Cold atmospheric plasma (CAP) is a near room temperature ionized gas composed…
We derived an ordinary differential equation model to capture the disease dynamics during blood-stage malaria. The model was directly derived from an earlier age-structured partial differential equation model. The original model was…
We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…