Biological Physics
Animals chain movements into long-lived motor strategies, exhibiting variability across scales that reflects the interplay between internal states and environmental cues. To reveal structure in such variability, we build Markov models of…
The mobility of particles in fluid membranes is a fundamental aspect of many biological processes. In a 1975 paper [1], Saffman and Delbr\"uck demonstrated how the presence of external Stokesian solvents is crucial in regularising the…
Saccharum spontaneum is a grass-type plant abundantly found in the Indian subcontinent, known for its beautiful, lustrous white flowers. Fibres were extracted from the flower and analyzed for their physical, mechanical, and chemical…
Understanding how fluctuations propagate across spatial scales is central to our understanding of inanimate matter from turbulence to critical phenomena. In contrast to physical systems, biological systems are organized into a hierarchy of…
Single-enzyme catalysis offers a promising approach for unravelling the dynamic behaviour of individual enzymes as they undergo a reaction, revealing the complex heterogeneity that is lost in the averaged ensembles. Here we demonstrate…
Fluid flow and mass transfer inside a bioreactor play a pivotal role in growing bone grafts, as cell proliferation is limited by the transport of nutrients and oxygen, as well as the removal of by-products from cells within the scaffold.…
The impact of cell segregation and margination in blood disorders on microcirculatory hemodynamics within bifurcated vessels are physiologically significant, yet poorly understood. This study presents a comprehensive computational…
Active particle systems of interacting self-propelled particles offer a versatile framework for modeling complex systems. When employed to describe aspects of animal behavior, the complexity of animal movement and decision-making often…
Ptychography is an attractive advance of coherent diffraction imaging (CDI), which can provide high lateral resolution and wide field of view. The theoretical resolution of ptychography is dose-limited, therefore making ptychography…
Red blood cells (RBCs) are responsible for transporting oxygen and various metabolites to tissues and organs, as well as removing waste. Several cardiovascular diseases can impair these functions. For instance, in diabetes, increased RBC…
The swimming motility of bacteria is driven by the action of bacterial flagellar motors, whose outermost structure is a long and thin helicoidal filament. When rotated, the fluid medium exerts an anisotropic viscous drag on the flagellar…
Exerting forces on biomolecules inside living cells would allow us to probe their dynamic interactions in their native environment. Magnetic iron oxide nanoparticles represent a unique tool capable of pulling on biomolecules with the…
Microscale hydrogels comprised of macromolecular networks have increasingly been used for applications involving cell encapsulation, tissue engineering and for the storage and release of active cargo molecules. However, the majority of such…
Atomic force microscopy (AFM or SPM) imaging is one of the best matches with machine learning (ML) analysis among microscopy techniques. The digital format of AFM images allows for direct utilization in ML algorithms without the need for…
Bacterial heterogeneity is pivotal for adaptation to diverse environments, posing significant challenges in microbial diagnostics and therapeutic interventions. Recent advancements in high-resolution optical microscopy have revolutionized…
Motivated by elastography that utilizes tissue mechanical properties as biomarkers for liver disease, with the eventual objective of quantitatively linking histopathology and bulk mechanical properties, we develop a micromechanical modeling…
We observe that the time averaged continuous Price equation is identical to the positive momentum virial theorem, and we discuss the applications and implications of this connection.
Intrinsically disordered proteins and regions are increasingly appreciated for their abundance in the proteome and the many functional roles they play in the cell. In this short review, we describe a variety of approaches used to obtain…
Membrane proteins often need to be inserted into or attached on the cell membrane to perform their functions. Understanding their transmembrane topology and conformational dynamics during insertion is crucial for elucidating their roles.…
Single-molecule surface-induced fluorescence attenuation (smSIFA) is a precise method for studying the vertical movement of biological macromolecules using two-dimensional material acceptors. Unlike other methods, smSIFA is not influenced…