Biological Physics
The thermodynamic dissipation theory for the origin of life asserts a thermodynamic imperative for the origin of life, suggesting that the fundamental molecules of life originated as self-organized molecular photon dissipative structures…
We introduce an efficient discretization of a novel fractional-order adaptive exponential (FrAdEx) integrate-and-fire model, which is used to study the fractional-order dynamics of neuronal activities. The discretization is based on…
When exposed to a time-periodic chemical signal, an \textit{E.~coli} cell responds by modulating its receptor activity in a similar time-periodic manner. However, there exists a phase lag between the applied signal and the activity…
Within minutes of birth a newborn gnu or giraffe works to stand and walk, asserting postural balance and organised animate behaviour in an apparently goal-directed manner. In contrast, robots learning to stand and walk from scratch begin…
Effective vaccine prioritization is critical for epidemic control, yet real outbreaks exhibit memory effects that inflate state space and make long-term prediction and optimization challenging. As a result, many strategies are tuned to…
In biological cells, DNA replication is carried out by the replisome, a protein complex encompassing multiple DNA polymerases. DNA replication is semi-discontinuous: a DNA polymerase synthesizes one (leading) strand of the DNA continuously,…
The structural integrity of microtubules is paramount for cellular function. We present a theoretical analysis of their lattice fracture, focusing on the influence of multi-seam structures arising from monomer defects and aiming to provide…
One of the greatest challenges of terrestrial locomotion is resisting gravity. The morphological adaptive features of the limb long-bones of extant elephants, the heaviest living terrestrial animals, have previously been highlighted;…
In the 1970s, the renowned physicist Victor Weisskopf famously developed a research program to qualitatively explain properties of matter in terms of the fundamental constants of physics. But there was one type of matter prominently missing…
In recent years, there has been rapid advancement in single-molecule techniques, driven by their unparalleled precision in studying molecules whose sizes are beyond the diffraction limit. Among these techniques, optoplasmonic whispering…
Intracellular phagosomes have a lipid bilayer encapsulated fluidic shell outside the particle, on the outer side of which, molecular motors are attached. An optically trapped spherical birefringent particle phagosome provides an ideal…
Neutrophils play a central role in immunothrombosis through the formation of neutrophil extracellular traps (NETs), a process known as NETosis. Upon stimulation, neutrophils release decondensed chromatin structures enriched with proteolytic…
Radiation therapy is one of the most common cancer treatments, and dose optimization and targeting of radiation are crucial since both cancerous and healthy cells are affected. Different mathematical and computational approaches have been…
Biological membranes often exhibit heterogeneous protein patterns, which cells control. Strong patterns, like the polarity spot in budding yeast, can be described as surface condensates, formed by physical interactions between constituents.…
The density of a protein molecule is a key property within a variety of experimental techniques. We present a computational method for determining protein mass density that explicitly incorporates hydration effects. Our approach uses…
The genomic DNA of most bacteria is significantly underwound, which constrains the DNA molecule to adopt a branched plectoneme geometry. Moreover, biological functions like replication and transcription require that the two DNA strands be…
In nature, many unicellular organisms are able to swim with the help of beating filaments, where local energy input leads to cooperative undulatory beating motion. Here, we investigate by employing reinforcement learning how undulatory…
Cell migration is a fundamental process underlying the survival and function of both unicellular and multicellular organisms. Crawling motility in eukaryotic cells arises from cyclic protrusion and retraction driven by the cytoskeleton,…
Ventricular Fibrillation (VF) is a malignant cardiac arrhythmia and the leading cause of sudden cardiac death, characterized by disorganized, high-frequency ventricular activity that results in the rapid loss of coordinated pump function…
The impact of thermal stress on beneficial symbiosis, in the face of rapid climate change, remains poorly understood. We investigate this using the model system, Euprymna scolopes, the Hawaiian Bobtail Squid, and its bioluminescent…