Biological Physics
The conformal integration of nitrogen-vacancy (NV) center nanodiamond arrays onto soft, hydrated, curvilinear biological interfaces remain a fundamental challenge for in vivo quantum sensing and imaging. Conventional transfer techniques…
Biological membranes are dynamic surfaces whose shape and function are critically influenced by protein inclusions (PIs). While membrane deformations induced by PIs have been extensively studied in the small-deformation regime, a variety of…
The relationship between the physical characteristics of the radiation field and biological damage is central to both radiotherapy and radioprotection, yet the link between spatial scales of energy deposition and biological effects remains…
The Hodgkin-Huxley equations have described neuronal excitability for seventy years, yet their mathematical structure-gating exponents m3h and n4, exponential voltage dependencies, and bounded activation variables, has remained empirically…
Developing epithelial tissues coordinate cell proliferation and mechanical forces to achieve proper size and shape. As epithelial cells tightly adhere together to form the confluent tissue, the distribution of cell areas significantly…
We present a model of active particles interacting through a dynamic, heterogeneous environment, leading to emergent collective behaviors without direct agent-to-agent communication. Expanding the resource-dependent framework introduced in…
Neural networks based on soft and biological matter constitute an interesting potential alternative to traditional implementations based on electric circuits. DNA is a particularly promising system in this context due its natural ability to…
A hallmark of biological tissues, viewed as complex cellular materials, is the active generation of mechanical stresses by cellular processes, such as cell divisions. Each cellular event generates a force dipole that deforms the surrounding…
Spider dragline silk supercontracts as humidity increases, displaying large axial shortening together with a reproducible macroscopic twist. The physical origin of this torsion remains debated and is often attributed to helically arranged…
Biological matrices are rich in information related to life processes, serving as invaluable media for assessing an individual's overall physiological status and its dynamic fluctuations, as well as crucial foundations for disease…
RNA polymerase (RNAP) elongates RNA by walking along a DNA template and selectively incorporating ribonucleoside triphosphates (rNTPs). Rather than mechanically replicating the base sequence, RNAP conditions binding and chemistry on the…
Understanding how soft matter systems, including biological ones, can develop collective electromagnetic phenomena under external fields at ambient conditions remains a central challenge, as thermal fluctuations are generally expected to…
In multi-cellular organisms, cells differentiate into multiple types as they divide. States of these cell types, as well as their numbers, are known to be robust to external perturbations; as conceptualized by Waddington's epigenetic…
With the growing interest in graphene field-effect transistors (GFETs) for biosensing applications, there is a strong demand for strategies enabling flexible and multiplexed biofunctionalization, as well as highly parallel, real-time…
TP53 is the most frequently mutated tumor suppressor gene in human cancers, with mutations primarily in its DNA-binding domain (p53-DBD). Mutations in p53-DBD are categorized into hotspot mutations (resulting in complete loss-of-function)…
We study stem-terminally differentiated (TD) lineages in small niches where demographic noise from discrete division and death events is non-negligible. Starting from a mechanistic five-channel, density-dependent CTMC (symmetric…
Efficient resolution of neuroinflammation and debris clearance is a key determinant of successful central nervous system regeneration. Regenerative vertebrates such as Danio rerio often exhibit faster immune resolution and debris clearance…
This work demonstrates efficient Forster resonance energy transfer (FRET) between ensembles of shallow nitrogen-vacancy (NV) centers located 7 nm and 9 nm below a single-crystal diamond surface and a naturally occurring fluorophore, namely…
Hour-glass clocks do not free-run; they keep time by riding an external rhythm. Motivated by the primordial KaiBC system in cyanobacteria, we study a driven, finite-state molecular clock that advances through a small number of biochemical…
We address the problem of inferring the location of a target that releases odor in the presence of turbulence. Input for the inference is provided by many sensors scattered within the odor plume. Drawing inspiration from distributed…