In clinical practice, many diagnosis tasks rely on the identification of cells in histopathology images. While supervised machine learning techniques require labels, providing manual cell annotations is time-consuming due to the large number of cells. In this paper, we propose a self-supervised framework (VOLTA) for cell representation learning in histopathology images using a novel technique that accounts for the cell's mutual relationship with its environment for improved cell representations. We subjected our model to extensive experiments on the data collected from multiple institutions around the world comprising of over 700,000 cells, four cancer types, and cell types ranging from three to six categories for each dataset. The results show that our model outperforms the state-of-the-art models in cell representation learning. To showcase the potential power of our proposed framework, we applied VOLTA to ovarian and endometrial cancers with very small sample sizes (10-20 samples) and demonstrated that our cell representations can be utilized to identify the known histotypes of ovarian cancer and provide novel insights that link histopathology and molecular subtypes of endometrial cancer. Unlike supervised deep learning models that require large sample sizes for training, we provide a framework that can empower new discoveries without any annotation data in situations where sample sizes are limited.
@article{arxiv.2303.04696,
title = {VOLTA: an Environment-Aware Contrastive Cell Representation Learning for Histopathology},
author = {Ramin Nakhli and Allen Zhang and Hossein Farahani and Amirali Darbandsari and Elahe Shenasa and Sidney Thiessen and Katy Milne and Jessica McAlpine and Brad Nelson and C Blake Gilks and Ali Bashashati},
journal= {arXiv preprint arXiv:2303.04696},
year = {2023}
}