English

Viscous vertex model for active epithelial tissues

Biological Physics 2026-03-31 v2

Abstract

We present a rotationally invariant viscous vertex model that accounts for both cortical and bulk dissipation of cells. The vanishing substrate-friction limit is enforced via Lagrange multipliers, which also provides a framework for implementing various boundary conditions, such as fixed boundaries and prescribed tractions. Building on this formulation, we introduce a slab-shear rheology protocol to extract an effective, coarse-grained tissue shear viscosity. Under polar or nematic activity, viscosity regulates the formation of elongated, spatially correlated cell-shape textures and stabilizes well-defined topological defects. Because the model remains well-posed at zero substrate friction, it is naturally suited to describing free-floating epithelia and organoids.

Keywords

Cite

@article{arxiv.2602.13049,
  title  = {Viscous vertex model for active epithelial tissues},
  author = {Shao-Zhen Lin and Sham Tlili and Jean-François Rupprecht},
  journal= {arXiv preprint arXiv:2602.13049},
  year   = {2026}
}
R2 v1 2026-07-01T10:35:30.430Z