Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.
@article{arxiv.0811.4025,
title = {VE-cadherin and claudin-5: it takes two to tango},
author = {Julie Gavard and J Silvio Gutkind},
journal= {arXiv preprint arXiv:0811.4025},
year = {2008}
}