Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
Other Quantitative Biology
2024-08-28 v1
Abstract
A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction. We identified specific Parkinson's genes differentially expressed post-spaceflight. These evidences indicate that spaceflight stressor-induced changes in the brain may become permanent during deep space exploration, posing a risk of PD in astronauts
Cite
@article{arxiv.2408.15021,
title = {Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight},
author = {Nilufar Ali and Afshin Beheshti and Greg Hampikian},
journal= {arXiv preprint arXiv:2408.15021},
year = {2024}
}
Comments
2 figures and 1 table