Universal Transitions between Growth and Dormancy via Intermediate Complex Formation
Cell Behavior
2025-03-12 v1 Biological Physics
Abstract
A simple cell model consisting of a catalytic reaction network with intermediate complex formation is numerically studied. As nutrients are depleted, the transition from the exponential growth phase to the growth-arrested dormant phase occurs along with hysteresis and a lag time for growth recovery. This transition is caused by the accumulation of intermediate complexes, leading to the jamming of reactions and the diversification of components. These properties are generic in random reaction networks, as supported by dynamical systems analyses of corresponding mean-field models.
Keywords
Cite
@article{arxiv.2304.04239,
title = {Universal Transitions between Growth and Dormancy via Intermediate Complex Formation},
author = {Jumpei F. Yamagishi and Kunihiko Kaneko},
journal= {arXiv preprint arXiv:2304.04239},
year = {2025}
}
Comments
6+6 pages, 3+6 figures