Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
Abstract
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult. Results: We present SignaLink, a database containing 8 major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster, and humans. Based on 170 review and approx. 800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the 8 pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery. Conclusions: We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease and underscore its importance in network-based drug target selection. Availability: http://SignaLink.org
Keywords
Cite
@article{arxiv.1008.4025,
title = {Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery},
author = {Tamas Korcsmaros and Illes J. Farkas and Maté S. Szalay and Petra Rovo and David Fazekas and Zoltan Spiro and Csaba Bode and Katalin Lenti and Tibor Vellai and Peter Csermely},
journal= {arXiv preprint arXiv:1008.4025},
year = {2010}
}
Comments
9 pages, 4 figures, 2 tables and a supplementary info with 5 Figures and 13 Tables