umx version 4.5: Extending Twin and Path-Based SEM in R with CLPM, MR-DoC, Definition Variables, $\Omega$nyx Integration, and Censored Distributions
Abstract
Structural Equation Modeling (SEM) is a flexible statistical technique with multiple applications, including behavioral genetics and social sciences. Building on the original design of the umx package, which improved accessibility to OpenMx by specifying a concise syntax, umx v4.5 extends functionality for longitudinal and causal twin designs while improving interoperability with graphical modelling tools such as Onyx. New capabilities include: classic and modern cross-lagged panel models; Mendelian Randomization Direction-of-Causation (MR-DoC) twin models incorporating polygenic scores as instruments; support for definition variables directly in umxRAM(); a workflow for importing paths from {\Omega}nyx; a dedicated function for incorporating censored variables' data into models, particularly valuable in biomarker research; improved covariate placeholder handling for definition variables; sex-limitation modelling across five twin groups, accommodating quantitative and qualitative sex differences; and covariate residualization in wide- or long-format data. These new functionalities accelerate reproducible, reliable, publication-ready twin and family modelling, and integrated journal-quality reporting, thereby lowering barriers to genetic epidemiological analyzes.
Keywords
Cite
@article{arxiv.2512.11063,
title = {umx version 4.5: Extending Twin and Path-Based SEM in R with CLPM, MR-DoC, Definition Variables, $\Omega$nyx Integration, and Censored Distributions},
author = {Luis FS Castro-de-Araujo and Nathan Gillespie and Michael C Neale and Timothy Bates},
journal= {arXiv preprint arXiv:2512.11063},
year = {2026}
}
Comments
13 pages, 2 figures